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Myosin 6 is a monomer

Posted by mpeckham on 12 May 2009 at 06:30 GMT

I'm not sure why this mutation would interfere with 'walking' since myosin 6 is a monomer (Buss et al., 2004, Embo J) (Knight et al., 2005, J. Biol. Chem), and (Spink et al., 2008, NSMB).

No competing interests declared.

RE: Myosin 6 is a monomer

Lee_Sweeney replied to mpeckham on 14 Aug 2009 at 03:33 GMT

Myosin VI is a dimer when bound to cargo and likely always functions as a dimer in cells. It is a monomer when inactive.
References to date (more to come soon):

1) Myosin VI Dimerization Triggers an Unfolding of a Three-Helix Bundle in Order to Extend Its Reach.
Mukherjea M, Llinas P, Kim H, Travaglia M, Safer D, Ménétrey J, Franzini-Armstrong C, Selvin PR, Houdusse A, Sweeney HL.
Mol Cell. 2009 Aug 5. [Epub ahead of print]

2) Myosin VI undergoes cargo-mediated dimerization.
Yu C, Feng W, Wei Z, Miyanoiri Y, Wen W, Zhao Y, Zhang M.
Cell. 2009 Aug 7;138(3):537-48.

3) Full-length myosin VI dimerizes and moves processively along actin filaments upon monomer clustering.
Park H, Ramamurthy B, Travaglia M, Safer D, Chen LQ, Franzini-Armstrong C, Selvin PR, Sweeney HL.
Mol Cell. 2006 Feb 3;21(3):331-6.

No competing interests declared.