Requirements for F-BAR Proteins TOCA-1 and TOCA-2 in Actin Dynamics and Membrane Trafficking during Caenorhabditis elegans Oocyte Growth and Embryonic Epidermal Morphogenesis

Chiara Giuliani; Flavia Troglio; Zhiyong Bai; Falshruti B. Patel; Adriana Zucconi; Maria Grazia Malabarba; Andrea Disanza; Theresia B. Stradal; Giuseppe Cassata; Stefano Confalonieri; Jeffrey D. Hardin; Martha C. Soto; Barth D. Grant; Giorgio Scita

doi:10.1371/journal.pgen.1000675

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Research Article

Requirements for F-BAR Proteins TOCA-1 and TOCA-2 in Actin Dynamics and Membrane Trafficking during Caenorhabditis elegans Oocyte Growth and Embryonic Epidermal Morphogenesis

Chiara Giuliani ,

Contributed equally to this work with: Chiara Giuliani, Flavia Troglio, Zhiyong Bai

Affiliation The FIRC Institute for Molecular Oncology, Milan, Italy
⨯
Flavia Troglio ,

Contributed equally to this work with: Chiara Giuliani, Flavia Troglio, Zhiyong Bai

Affiliation The FIRC Institute for Molecular Oncology, Milan, Italy
⨯
Zhiyong Bai ,

Contributed equally to this work with: Chiara Giuliani, Flavia Troglio, Zhiyong Bai

Affiliation Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, New Jersey, United States of America
⨯
Falshruti B. Patel,

Affiliation Department of Pathology and Laboratory Medicine, University of Medicine and Dentistry New Jersey—Robert Wood Johnson Medical School, Piscataway, New Jersey, United States of America
⨯
Adriana Zucconi,

Affiliation The FIRC Institute for Molecular Oncology, Milan, Italy
⨯
Maria Grazia Malabarba,

Affiliations The FIRC Institute for Molecular Oncology, Milan, Italy, University of Milan Medical School, Milan, Italy
⨯
Andrea Disanza,

Affiliation The FIRC Institute for Molecular Oncology, Milan, Italy
⨯
Theresia B. Stradal,

Affiliations Signalling and Motility Group, Helmholtz Centre for Infection Research, Braunschweig, Germany, University of Bonn, Bonn, Germany
⨯
Giuseppe Cassata,

Affiliation The FIRC Institute for Molecular Oncology, Milan, Italy
⨯
Stefano Confalonieri,

Affiliation The FIRC Institute for Molecular Oncology, Milan, Italy
⨯
Jeffrey D. Hardin,

Affiliation Department of Zoology, University of Wisconsin, Madison, Wisconsin, United States of America
⨯
Martha C. Soto,

Affiliation Department of Pathology and Laboratory Medicine, University of Medicine and Dentistry New Jersey—Robert Wood Johnson Medical School, Piscataway, New Jersey, United States of America
⨯
Barth D. Grant ,

* E-mail: Giorgio.scita@ifom-ieo-campus.it (GS); grant@dls.rutgers.edu (BDG)

¶These authors contributed equally to this work.

Affiliation Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, New Jersey, United States of America
⨯
Giorgio Scita

* E-mail: Giorgio.scita@ifom-ieo-campus.it (GS); grant@dls.rutgers.edu (BDG)

¶These authors contributed equally to this work.

Affiliations The FIRC Institute for Molecular Oncology, Milan, Italy, University of Milan Medical School, Milan, Italy
⨯

Requirements for F-BAR Proteins TOCA-1 and TOCA-2 in Actin Dynamics and Membrane Trafficking during Caenorhabditis elegans Oocyte Growth and Embryonic Epidermal Morphogenesis

Chiara Giuliani,
Flavia Troglio,
Zhiyong Bai,
Falshruti B. Patel,
Adriana Zucconi,
Maria Grazia Malabarba,
Andrea Disanza,
Theresia B. Stradal,
Giuseppe Cassata,
Stefano Confalonieri

Published: October 2, 2009
https://doi.org/10.1371/journal.pgen.1000675

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Acknowledgments

Posted by cgiulian on 05 Oct 2009 at 13:36 GMT

We thank Dr. Shohei Mitani and the National BioResource Project for C. elegans (Japan) for generating tm2056, tm3334, and tm2088. Some nematode strains used in this work were provided by the Caenorhabditis Genetics Center, which is funded by the NIH National Center for Research Resources (NCRR). We thank Holger Kloess for technical help. We also thank Dr. Gian Garriga and Dr. Shiro Suetsugu for WSP-1 antibody
http://plosgenetics.org/article/info:doi/10.1371/journal.pgen.1000675#article1.back1.ack1.p1

We thank Dr. Ronen Zaidel-Bar for generating some of the critical reagents used to characterize the role of tocas in embryonic development.

No competing interests declared.

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Requirements for F-BAR Proteins TOCA-1 and TOCA-2 in Actin Dynamics and Membrane Trafficking during Caenorhabditis elegans Oocyte Growth and Embryonic Epidermal Morphogenesis

Requirements for F-BAR Proteins TOCA-1 and TOCA-2 in Actin Dynamics and Membrane Trafficking during Caenorhabditis elegans Oocyte Growth and Embryonic Epidermal Morphogenesis

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Posted by cgiulian on 05 Oct 2009 at 13:36 GMT