TY - JOUR T1 - The Nuclear Receptor DHR3 Modulates dS6 Kinase–Dependent Growth in Drosophila A1 - Montagne, Jacques A1 - Lecerf, Caroline A1 - Parvy, Jean-Philippe A1 - Bennion, Janis M. A1 - Radimerski, Thomas A1 - Ruhf, Marie-Laure A1 - Zilbermann, Frederic A1 - Vouilloz, Nicole A1 - Stocker, Hugo A1 - Hafen, Ernst A1 - Kozma, Sara C. A1 - Thomas, George Y1 - 2010/05/06 N2 - Author Summary In biological systems, the execution of morphogenic programs requires coordinated integration of the essential processes of growth, proliferation, and differentiation. Signaling networks embedded within these processes include the insulin and nutrient pathways required for cell growth and the steroid hormone-regulated pathways that control discrete developmental steps. Although these pathways are known to be integrated and coordinated, the molecular bridges that link them remain to be identified. Taking advantage of Drosophila, we performed a genetic screen for novel regulators of the dS6K, which previously has been identified as a key effector of cell growth downstream of insulin and nutrient signaling. Unexpectedly, we identified the nuclear receptor DHR3, a key regulator of morphogenesis, as a potent modulator of dS6K–mediated cell growth. Nuclear receptors typically comprise a DNA–binding domain and a regulatory ligand-binding domain. Here we show that a DHR3 isoform, devoid of the DNA–binding domain is sufficient to potentiate dS6K–mediated cell growth through its ligand-binding domain. We further demonstrate that, like dS6K, DHR3 regulates cell-autonomous growth. These data provide a unique molecular link between steroid-regulated development and nutrient-dependent growth. JF - PLOS Genetics JA - PLOS Genetics VL - 6 IS - 5 UR - https://doi.org/10.1371/journal.pgen.1000937 SP - e1000937 EP - PB - Public Library of Science M3 - doi:10.1371/journal.pgen.1000937 ER -