TY - JOUR T1 - Population Genomics of Parallel Adaptation in Threespine Stickleback using Sequenced RAD Tags A1 - Hohenlohe, Paul A. A1 - Bassham, Susan A1 - Etter, Paul D. A1 - Stiffler, Nicholas A1 - Johnson, Eric A. A1 - Cresko, William A. Y1 - 2010/02/26 N2 - Author Summary Oceanic threespine stickleback have invaded and adapted to freshwater habitats countless times across the northern hemisphere. These freshwater populations have often evolved in similar ways from the ancestral marine stock from which they independently derived. With the exception of a few identified genes, the genetic basis of this remarkable parallel adaptation is unclear. Here we show that the parallel phenotypic evolution is matched by parallel patterns of nucleotide diversity and population differentiation across the genome. We used a novel high-throughput sequence-based genotyping approach to produce the first high density genome-wide scans of threespine stickleback populations and identified several genomic regions indicative of both divergent and balancing selection. Some of these regions have been associated previously with traits important for freshwater adaptation, but others were previously unidentified. Within these genomic regions we identified candidate genes, laying the foundation for further genetic and functional study of key pathways. This research illustrates the complementary nature of laboratory mapping, functional genetics, and population genomics. JF - PLOS Genetics JA - PLOS Genetics VL - 6 IS - 2 UR - https://doi.org/10.1371/journal.pgen.1000862 SP - e1000862 EP - PB - Public Library of Science M3 - doi:10.1371/journal.pgen.1000862 ER -