About the Authors

Thomas W. Winkler

Contributed equally to this work with: Thomas W. Winkler, Anne E. Justice, Mariaelisa Graff, Llilda Barata

Affiliation Department of Genetic Epidemiology, Institute of Epidemiology and Preventive Medicine, University Regensburg, Regensburg, Germany

Anne E. Justice

Contributed equally to this work with: Thomas W. Winkler, Anne E. Justice, Mariaelisa Graff, Llilda Barata

Affiliation Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

Mariaelisa Graff

Contributed equally to this work with: Thomas W. Winkler, Anne E. Justice, Mariaelisa Graff, Llilda Barata

Affiliation Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

Llilda Barata

Contributed equally to this work with: Thomas W. Winkler, Anne E. Justice, Mariaelisa Graff, Llilda Barata

Affiliation Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of America

Mary F. Feitosa

Affiliation Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of America

Su Chu

Affiliation Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, United States of America

Jacek Czajkowski

Affiliation Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of America

Tõnu Esko

Affiliations Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts, United States of America, Divisions of Endocrinology and Genetics and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, Massachusetts, United States of America, Estonian Genome Center, Univeristy of Tartu, Tartu, Estonia, Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America

Tove Fall

Affiliations Science for Life Laboratory, Uppsala University, Uppsala, Sweden, Department of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala, Sweden

Tuomas O. Kilpeläinen

Affiliations Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark, MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom

Yingchang Lu

Affiliations The Charles Bronfman Institute for Personalized Medicine, The Icahn School of Medicine at Mount Sinai, New York, New York, United States of America, The Department of Preventive Medicine, The Icahn School of Medicine at Mount Sinai, New York, New York, United States of America

Reedik Mägi

Affiliations Estonian Genome Center, Univeristy of Tartu, Tartu, Estonia, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

Evelin Mihailov

Affiliation Estonian Genome Center, Univeristy of Tartu, Tartu, Estonia

Tune H. Pers

Affiliations Divisions of Endocrinology and Genetics and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, Massachusetts, United States of America, Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America, Medical and Population Genetics Program, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America

Sina Rüeger

Affiliations Swiss Institute of Bioinformatics, Lausanne, Switzerland, Institute of Social and Preventive Medicine, University Hospital Lausanne (CHUV), Lausanne, Switzerland

Alexander Teumer

Affiliations Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany, Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany

Georg B. Ehret

Affiliations Department of Specialties of Internal Medicine, Geneva University Hospital, Geneva, Switzerland, Center for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

Teresa Ferreira

Affiliation Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

Nancy L. Heard-Costa

Affiliations Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, United States of America, National Heart, Lung, and Blood Institute, the Framingham Heart Study, Framingham, Massachusetts, United States of America

Juha Karjalainen

Affiliation University of Groningen, University Medical Center Groningen, Department of Genetics, Groningen, The Netherlands

Vasiliki Lagou

Affiliations Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom, Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, United Kingdom

Anubha Mahajan

Affiliation Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

Michael D. Neinast

Affiliation Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America

Inga Prokopenko

Affiliations Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom, Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, United Kingdom, Hammersmith Hospital, London, United Kingdom, Department of Genomics of Common Diseases, School of Public Health, Imperial College London, London, United Kingdom

Jeannette Simino

Affiliation Division of Biostatistics, Washington University School of Medicine, St. Louis, Missouri, United States of America

Tanya M. Teslovich

Affiliation Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, United States of America

Rick Jansen

Affiliation Department of Psychiatry and EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, the Netherlands

Harm-Jan Westra

Affiliations Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Divisions of Genetics and Rheumatology, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, United States of America, Partners Center for Personalized Genetic Medicine, Boston, Massachusetts, United States of America

Charles C. White

Affiliation Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America

Devin Absher

Affiliation HudsonAlpha Institute for Biotechnology, Huntsville, Alabama, United States of America

Tarunveer S. Ahluwalia

Affiliations Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark, Steno Diabetes Center A/S, Gentofte, Denmark, COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark

Shafqat Ahmad

Affiliation Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Skåne University Hospital Malmö, Malmö, Sweden

Eva Albrecht

Affiliation Institute of Genetic Epidemiology, Helmholtz Zentrum München—German Research Center for Environmental Health, Neuherberg, Germany

Alexessander Couto Alves

Affiliation Department of Epidemiology and Biostatistics, MRC Health Protection Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College, London, United Kingdom

Jennifer L. Bragg-Gresham

Affiliation Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, United States of America

Anton J. M. de Craen

Affiliation Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands

Joshua C. Bis

Affiliations Cardiovascular Health Research Unit, University of Washington, Seattle, Washington, United States of America, Department of Medicine, University of Washington, Seattle, Washington, United States of America

Amélie Bonnefond

Affiliations CNRS UMR 8199, Lille, France, European Genomic Institute for Diabetes, Lille, France, Université de Lille 2, Lille, France

Gabrielle Boucher

Affiliation Montreal Heart Institute, Montréal, Québec, Canada

Gemma Cadby

Affiliation Centre for Genetic Origins of Health and Disease, University of Western Australia, Crawley, Western Australia, Australia

Yu-Ching Cheng

Affiliations VA Maryland Health Care System, Baltimore, Maryland, United States of America, University of Maryland School of Medicine, Department of Medicine, Baltimore, Maryland, United States of America

Charleston W. K. Chiang

Affiliation Department of Ecology and Evolutionary Biology, University of California, Los Angeles, Los Angeles, California, United States of America

Graciela Delgado

Affiliation Vth Department of Medicine, Mannheim Medical Faculty, University of Heidelberg, Mannheim, Germany

Ayse Demirkan

Affiliation Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands

Nicole Dueker

Affiliation Universiy of Maryland School of Medicine, Department of Epidemiology & Public Health, Baltimore, Maryland, United States of America

Niina Eklund

Affiliations National Institute for Health and Welfare, Department of Chronic Disease Prevention, Helsinki, Finland, National Institute for Health and Welfare, Public Health Genomics Unit, Helsinki, Finland, Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland

Gudny Eiriksdottir

Affiliation Icelandic Heart Association, Kopavogur, Iceland

Joel Eriksson

Affiliation Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

Bjarke Feenstra

Affiliation Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark

Krista Fischer

Affiliation Estonian Genome Center, Univeristy of Tartu, Tartu, Estonia

Francesca Frau

Affiliations Department of Health Sciences, University of Milan, Milan, Italy, Filarete Foundation, Genomic and Bioinformatics Unit, Milano, Italy

Tessel E. Galesloot

Affiliation Radboud university medical center, Radboud Institute for Health Sciences, Department for Health Evidence, Nijmegen, The Netherlands

Frank Geller

Affiliation Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark

Anuj Goel

Affiliations Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom, Division of Cardiovacular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom

Mathias Gorski

Affiliations Department of Genetic Epidemiology, Institute of Epidemiology and Preventive Medicine, University Regensburg, Regensburg, Germany, Department of Nephrology, University Hospital Regensburg, Regensburg, Germany

Tanja B. Grammer

Affiliation Vth Department of Medicine, Mannheim Medical Faculty, University of Heidelberg, Mannheim, Germany

Stefan Gustafsson

Affiliations Science for Life Laboratory, Uppsala University, Uppsala, Sweden, Department of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala, Sweden

Saskia Haitjema

Affiliation Experimental Cardiology and laboratory of clinical chemistry, UMCU, Utrecht, The Netherlands

Jouke-Jan Hottenga

Affiliation Department of Biological Psychology, VU University, Amsterdam, The Netherlands

Jennifer E. Huffman

Affiliations National Heart, Lung, and Blood Institute, the Framingham Heart Study, Framingham, Massachusetts, United States of America, MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, Scotland

Anne U. Jackson

Affiliation Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, United States of America

Kevin B. Jacobs

Affiliations Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America, Core Genotyping Facility, SAIC-Frederick, Inc., NCI-Frederick, Frederick, Maryland, United States of America

Åsa Johansson

Affiliations Science for Life Laboratory, Uppsala University, Uppsala, Sweden, Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden

Marika Kaakinen

Affiliations Department of Epidemiology and Biostatistics, MRC Health Protection Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College, London, United Kingdom, Institute of Health Sciences, University of Oulu, Oulu, Finland

Marcus E. Kleber

Affiliation Vth Department of Medicine, Mannheim Medical Faculty, University of Heidelberg, Mannheim, Germany

Jari Lahti

Affiliations Folkhälsan Research Centre, Helsinki, Finland, Institute of Behavioural Sciences, University of Helsinki, Helsinki, Finland

Irene Mateo Leach

Affiliation University of Groningen, University Medical Center Groningen, Department of Cardiology, Groningen, Netherlands

Benjamin Lehne

Affiliation Department of Epidemiology and Biostatistics, Imperial College London, London, United Kingdom

Youfang Liu

Affiliation Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chaper Hill, North Carolina, United States of America

Ken Sin Lo

Affiliation Montreal Heart Institute, Montréal, Québec, Canada

Mattias Lorentzon

Affiliation Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

Jian'an Luan

Affiliation MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom

Pamela A. F. Madden

Affiliation Washington University Medical School, St. Louis, Missouri, United States of America

Massimo Mangino

Affiliation Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom

Barbara McKnight

Affiliations Cardiovascular Health Research Unit, University of Washington, Seattle, Washington, United States of America, Program in Biostatistics and Biomathematics, Divison of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America, Department of Biostatistics, University of Washington, Seattle, Washington, United States of America

Carolina Medina-Gomez

Affiliations Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), The Netherlands, Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands, Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands

Keri L. Monda

Affiliations Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America, The Center for Observational Research, Amgen Inc., Thousand Oaks, California, United States of America

May E. Montasser

Affiliation Program for Personalized and Genomic Medicine, Division of Endocrinology, Diabetes & Nutrition, Dept of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, United States of America

Gabriele Müller

Affiliation Center for Evidence Based Healthcare, University of Dresden, Medical Faculty Carl Gustav Carus, Dresden, Germany

Martina Müller-Nurasyid

Affiliations Institute of Genetic Epidemiology, Helmholtz Zentrum München—German Research Center for Environmental Health, Neuherberg, Germany, Department of Medicine I, University Hospital Grosshadern, Ludwig-Maximilians-Universität, Munich, Germany, Institute of Medical Informatics, Biometry and Epidemiology, Chair of Genetic Epidemiology, Ludwig-Maximilians-Universität, Munich, Germany, DZHK (German Centre for Cardiovascular Research), partnersite Munich Heart Alliance, Munich, Germany

Ilja M. Nolte

Affiliation University of Groningen, University Medical Center Groningen, Department of Epidemiology, Groningen, The Netherlands

Kalliope Panoutsopoulou

Affiliation Wellcome Trust Sanger Institute, Human Genetics, Hinxton, Cambridge, United Kingdom

Laura Pascoe

Affiliation Institute of Cell & Molecular Biosciences, Newcastle University, Newcastle, United Kingdom

Lavinia Paternoster

Affiliation MRC Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom

Nigel W. Rayner

Affiliations Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom, Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, United Kingdom, Wellcome Trust Sanger Institute, Human Genetics, Hinxton, Cambridge, United Kingdom

Frida Renström

Affiliation Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Skåne University Hospital Malmö, Malmö, Sweden

Federica Rizzi

Affiliations Department of Health Sciences, University of Milan, Milan, Italy, Filarete Foundation, Genomic and Bioinformatics Unit, Milano, Italy

Lynda M. Rose

Affiliation Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States of America

Kathy A. Ryan

Affiliation Program for Personalized and Genomic Medicine, Division of Endocrinology, Diabetes & Nutrition, Dept of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, United States of America

Perttu Salo

Affiliations National Institute for Health and Welfare, Department of Chronic Disease Prevention, Helsinki, Finland, National Institute for Health and Welfare, Public Health Genomics Unit, Helsinki, Finland

Serena Sanna

Affiliation Istituto di Ricerca Genetica e Biomedica, CNR, Monserrato, Italy

Hubert Scharnagl

Affiliation Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria

Jianxin Shi

Affiliation National Cancer Institute, Bethesda, Maryland, United States of America

Albert Vernon Smith

Affiliations Icelandic Heart Association, Kopavogur, Iceland, Faculty of Medicine, University of Iceland, Reykjavik, Iceland

Lorraine Southam

Affiliations Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom, Wellcome Trust Sanger Institute, Human Genetics, Hinxton, Cambridge, United Kingdom

Alena Stančáková

Affiliation Department of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland

Valgerdur Steinthorsdottir

Affiliation deCODE Genetics, Amgen inc., Reykjavik, Iceland

Rona J. Strawbridge

Affiliations Atherosclerosis Research Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden, Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden

Yun Ju Sung

Affiliation Division of Biostatistics, Washington University School of Medicine, St. Louis, Missouri, United States of America

Ioanna Tachmazidou

Affiliation Wellcome Trust Sanger Institute, Human Genetics, Hinxton, Cambridge, United Kingdom

Toshiko Tanaka

Affiliation Translational Gerontology Branch, National Institute on Aging, Baltimore, Maryland, United States of America

Gudmar Thorleifsson

Affiliation deCODE Genetics, Amgen inc., Reykjavik, Iceland

Stella Trompet

Affiliations Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands, Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands

Natalia Pervjakova

Affiliations Estonian Genome Center, Univeristy of Tartu, Tartu, Estonia, National Institute for Health and Welfare, Public Health Genomics Unit, Helsinki, Finland, Institute of Cell and Molecular Biology, Department of Biotechnology, University of Tartu, Tartu, Estonia, University of Helsinki, Helsinki, Finland

Jonathan P. Tyrer

Affiliation Department of Oncology, University of Cambridge, Cambridge, United Kingdom

Liesbeth Vandenput

Affiliation Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

Sander W van der Laan

Affiliation Experimental Cardiology and laboratory of clinical chemistry, UMCU, Utrecht, The Netherlands

Nathalie van der Velde

Affiliations Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands, Department of Internal Medicine, Section of Geriatric Medicine, Academic Medical Center, Amsterdam, The Netherlands

Jessica van Setten

Affiliation Department of Medical Genetics, University Medical Center Utrecht, Utrecht, Netherlands

Jana V. van Vliet-Ostaptchouk

Affiliation University of Groningen, University Medical Center Groningen, Department of Endocrinology, Groningen, The Netherlands

Niek Verweij

Affiliation University of Groningen, University Medical Center Groningen, Department of Cardiology, Groningen, Netherlands

Efthymia Vlachopoulou

Affiliation Transplantation Laboratory, Haartman Institute, University of Helsinki, Helsinki, Finland

Lindsay L. Waite

Affiliation HudsonAlpha Institute for Biotechnology, Huntsville, Alabama, United States of America

Sophie R. Wang

Affiliations Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America, Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Division of Endocrinology, Boston Children's Hospital, Boston, Massachusetts, United States of America, Divisions of Genetics and Endocrinology and Program in Genomics, Boston's Children's Hospital, Boston, Massachusetts, United States of America

Zhaoming Wang

Affiliations Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America, Core Genotyping Facility, SAIC-Frederick, Inc., NCI-Frederick, Frederick, Maryland, United States of America

Sarah H. Wild

Affiliation Centre for Population Health Sciences, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, Scotland

Christina Willenborg

Affiliations DZHK (German Centre for Cardiovascular Research), partner site Hamburg/Kiel/Lübeck, Lübeck, Germany, Institut für Integrative und Experimentelle Genomik, Universität zu Lübeck, Lübeck, Germany

James F. Wilson

Affiliation Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, Scotland

Andrew Wong

Affiliation MRC Unit for Lifelong Health & Ageing at UCL, London, United Kingdom

Jian Yang

Affiliation Queensland Brain Institute, The University of Queensland, Brisbane, Queensland, Australia

Loïc Yengo

Affiliations CNRS UMR 8199, Lille, France, European Genomic Institute for Diabetes, Lille, France, Université de Lille 2, Lille, France

Laura M. Yerges-Armstrong

Affiliation Program for Personalized and Genomic Medicine, Division of Endocrinology, Diabetes & Nutrition, Dept of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, United States of America

Lei Yu

Affiliation Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, United States of America

Weihua Zhang

Affiliations Department of Epidemiology and Biostatistics, Imperial College London, London, United Kingdom, Ealing Hospital NHS Trust, Middlesex, United Kingdom

Jing Hua Zhao

Affiliation MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom

Ehm A. Andersson

Affiliation Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

Stephan J. L. Bakker

Affiliation University of Groningen, University Medical Center Groningen, Department of Medicine, Groningen, Netherlands

Damiano Baldassarre

Affiliations Centro Cardiologico Monzino, IRCCS, Milan, Italy, Dipartimento di Scienze Farmacologiche e Biomolecolari, Università di Milano, Milan, Italy

Karina Banasik

Affiliation Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

Matteo Barcella

Affiliation Department of Health Sciences, University of Milan, Milan, Italy

Cristina Barlassina

Affiliation Department of Health Sciences, University of Milan, Milan, Italy

Claire Bellis

Affiliations Department of Genetics, Texas Biomedical Research Institute, San Antonio, Texas, United States of America, Genomics Research Centre, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia

Paola Benaglio

Affiliations Department of Pediatrics, University of California San Diego, La Jolla, California, United States of America, Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland

John Blangero

Affiliation Department of Genetics, Texas Biomedical Research Institute, San Antonio, Texas, United States of America

Matthias Blüher

Affiliations University of Leipzig, IFB Adiposity Diseases, Leipzig, Germany, University of Leipzig, Department of Medicine, Leipzig, Germany

Fabrice Bonnet

Affiliation University Rennes 1, Rennes, France

Lori L. Bonnycastle

Affiliation Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, Maryland, United States of America

Heather A. Boyd

Affiliation Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark

Marcel Bruinenberg

Affiliation University of Groningen, University Medical Center Groningen, The LifeLines Cohort Study, Groningen, The Netherlands

Aron S Buchman

Affiliation Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, United States of America

Harry Campbell

Affiliation Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, Scotland

Yii-Der Ida Chen

Affiliation Los Angeles BioMedical Resesarch Institute at Harbor-UCLA Medical Center, Torrance, California, United States of America

Peter S. Chines

Affiliation Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, Maryland, United States of America

Simone Claudi-Boehm

Affiliation Department of Internal Medicine I, Ulm University Medical Centre, Ulm, Germany

John Cole

Affiliations VA Maryland Health Care System, Baltimore, Maryland, United States of America, Universiy of Maryland School of Medicine, Department of Neurology, Baltimore, Maryland, United States of America

Francis S. Collins

Affiliation Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, Maryland, United States of America

Eco J. C. de Geus

Affiliations Department of Biological Psychology, VU University, Amsterdam, The Netherlands, EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands

Lisette C. P. G. M. de Groot

Affiliation Department of Human Nutrition, Wageningen University, Wageningen, The Netherlands

Maria Dimitriou

Affiliations Wellcome Trust Sanger Institute, Human Genetics, Hinxton, Cambridge, United Kingdom, Department of Dietetics-Nutrition, Harokopio University, Athens, Greece

Jubao Duan

Affiliations NorthShore University HealthSystem, Evanston, Illinois, United States of America, University of Chicago, Chicago, Illinois, United States of America

Stefan Enroth

Affiliations Science for Life Laboratory, Uppsala University, Uppsala, Sweden, Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden

Elodie Eury

Affiliations CNRS UMR 8199, Lille, France, European Genomic Institute for Diabetes, Lille, France, Université de Lille 2, Lille, France

Aliki-Eleni Farmaki

Affiliation Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, Athens, Greece

Nita G. Forouhi

Affiliation MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom

Nele Friedrich

Affiliation Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany

Pablo V. Gejman

Affiliations NorthShore University HealthSystem, Evanston, Illinois, United States of America, University of Chicago, Chicago, Illinois, United States of America

Bruna Gigante

Affiliation Division of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden

Nicola Glorioso

Affiliation Hypertension and Related Disease Centre, AOU-University of Sassari, Sassari, Italy

Alan S. Go

Affiliation Kaiser Permanente, Division of Research, Oakland, California, United States of America

Omri Gottesman

Affiliations The Charles Bronfman Institute for Personalized Medicine, The Icahn School of Medicine at Mount Sinai, New York, New York, United States of America, The Department of Medicine, The Icahn School of Medicine at Mount Sinai, New York, New York, United States of America

Jürgen Gräßler

Affiliation Department of Medicine III, Pathobiochemistry, University of Dresden, Dresden, Germany

Harald Grallert

Affiliations Research Unit of Molecular Epidemiology, Helmholtz Zentrum München—German Research Center for Environmental Health, Neuherberg, Germany, Institute of Epidemiology II, Helmholtz Zentrum München—German Research Center for Environmental Health, Neuherberg, Germany, German Center for Diabetes Research (DZD), Neuherberg, Germany

Niels Grarup

Affiliation Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

Yu-Mei Gu

Affiliation Research Unit Hypertension and Cardiovascular Epidemiology, KU Leuven Department of Cardiovascular Sciences, University of Leuven, Leuven, Belgium

Linda Broer

Affiliation Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands

Annelies C. Ham

Affiliation Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands

Torben Hansen

Affiliations Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark

Tamara B. Harris

Affiliations Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Bethesda, Maryland, United States of America, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America

Catharina A. Hartman

Affiliation University of Groningen, University Medical Center Groningen, Department of Psychiatry, Groningen, The Netherlands

Maija Hassinen

Affiliation Kuopio Research Institute of Exercise Medicine, Kuopio, Finland

Nicholas Hastie

Affiliation MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, Scotland

Andrew T. Hattersley

Affiliation Institue of Biomedical & Clinical Science, University of Exeter, Exeter, United Kingdom

Andrew C. Heath

Affiliation Washington University Medical School, St. Louis, Missouri, United States of America

Anjali K. Henders

Affiliation QIMR Bergofer Medical Research Institute, Brisbane, Queensland, Australia

Dena Hernandez

Affiliation Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America

Hans Hillege

Affiliation University of Groningen, University Medical Center Groningen, Department of Cardiology, Groningen, Netherlands

Oddgeir Holmen

Affiliation Department of Public Health and General Practice, Norwegian University of Science and Technology, Trondheim, Norway

Kees G Hovingh

Affiliation Department Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands

Jennie Hui

Affiliations Pathwest Laboratory Medicine of Western Australia, Nedlands, Western Australia,Australia, School of Pathology and Laboratory Medicine, University of Western Australia, Nedlands, Western Australia, Australia, School of Population Health, University of Western Australia, Nedlands, Western Australia, Australia

Lise L. Husemoen

Affiliation Research Centre for Prevention and Health, Glostrup Hospital, Glostrup, Denmark

Nina Hutri-Kähönen

Affiliations Department of Pediatrics, University of Tampere School of Medicine, Tampere, Finland, Department of Pediatrics,Tampere University Hospital, Tampere, Finland

Pirro G. Hysi

Affiliation Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom

Thomas Illig

Affiliations Research Unit of Molecular Epidemiology, Helmholtz Zentrum München—German Research Center for Environmental Health, Neuherberg, Germany, Hannover Unified Biobank, Hannover Medical School, Hannover, Germany, Institute of Human Genetics, Hannover Medical School, Hanover, Germany

Philip L. De Jager

Affiliations Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Harvard Medical School, Boston, Massachusetts,United States of America, Program in Translational NeuroPsychiatric Genomics, Department of Neurology, Brigham and Women’s Hospital, Boston, Massachusetts,United States of America

Shapour Jalilzadeh

Affiliations Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom, Division of Cardiovacular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom

Torben Jørgensen

Affiliations Research Centre for Prevention and Health, Glostrup Hospital, Glostrup, Denmark, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark, Faculty of Medicine, University of Aalborg, Aalborg, Denmark

J. Wouter Jukema

Affiliations Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands, Interuniversity Cardiology Institute of the Netherlands, Utrecht, The Netherlands

Markus Juonala

Affiliations Division of Medicine, Turku University Hospital, Turku, Finland, Murdoch Children's Research Institute, Parkville, Victoria, Australia, Department of Medicine, University of Turku, Turku, Finland

Stavroula Kanoni

Affiliations Wellcome Trust Sanger Institute, Human Genetics, Hinxton, Cambridge, United Kingdom, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom

Maria Karaleftheri

Affiliation Echinos Medical Centre, Echinos, Greece

Kay Tee Khaw

Affiliation Clinical Gerontology Unit, Addenbrooke's Hospital, Cambridge, United Kingdom

Leena Kinnunen

Affiliation Department of Health, National Institute for Health and Welfare, Helsinki, Finland

Steven J. Kittner

Affiliations VA Maryland Health Care System, Baltimore, Maryland, United States of America, Universiy of Maryland School of Medicine, Department of Neurology, Baltimore, Maryland, United States of America

Wolfgang Koenig

Affiliation Department of Internal Medicine II—Cardiology, University of Ulm Medical Center, Ulm, Germany

Ivana Kolcic

Affiliation Department of Public Health, Faculty of Medicine, University of Split, Split, Croatia

Peter Kovacs

Affiliation University of Leipzig, IFB Adiposity Diseases, Leipzig, Germany

Nikolaj T. Krarup

Affiliation Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

Wolfgang Kratzer

Affiliation Department of Internal Medicine I, Ulm University Medical Centre, Ulm, Germany

Janine Krüger

Affiliation Department of Medicine A, University Medicine Greifswald, Greifswald, Germany

Diana Kuh

Affiliation MRC Unit for Lifelong Health & Ageing at UCL, London, United Kingdom

Meena Kumari

Affiliation Department of Epidemiology and Public Health, UCL, London, United Kingdom

Theodosios Kyriakou

Affiliations Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom, Division of Cardiovacular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom

Claudia Langenberg

Affiliations MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom, Department of Epidemiology and Public Health, UCL, London, United Kingdom

Lars Lannfelt

Affiliation Department of Public Health and Caring Sciences, Geriatrics, Uppsala University, Uppsala, Sweden

Chiara Lanzani

Affiliations Chair of Nephrology, Università Vita Salute San Raffaele, Segrate (Milan), Italy, Genomics of Renal Disease and Hypertension Unit, IRCCS San Raffaele Scientific Institute, Segrate (Milan), Italy

Vaneet Lotay

Affiliation Department of Biological Sciences, University of Calgary, Calgary, Alberta, Canada

Lenore J. Launer

Affiliation National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America

Karin Leander

Affiliation Division of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden

Jaana Lindström

Affiliation Diabetes Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland

Allan Linneberg

Affiliations Research Centre for Prevention and Health, Glostrup Hospital, Glostrup, Denmark, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark, Department of Clinical Experimental Research, Rigshospitalet, Glostrup, Denmark

Yan-Ping Liu

Affiliation Research Unit Hypertension and Cardiovascular Epidemiology, KU Leuven Department of Cardiovascular Sciences, University of Leuven, Leuven, Belgium

Stéphane Lobbens

Affiliations CNRS UMR 8199, Lille, France, European Genomic Institute for Diabetes, Lille, France, Université de Lille 2, Lille, France

Robert Luben

Affiliation Strangeways Research Laboratory Wort's Causeway, Cambridge, United Kingdom

Valeriya Lyssenko

Affiliations Steno Diabetes Center A/S, Gentofte, Denmark, Lund University Diabetes Centre and Department of Clinical Science, Diabetes & Endocrinology Unit, Lund University, Malmö, Sweden

Satu Männistö

Affiliation National Institute for Health and Welfare, Department of Chronic Disease Prevention, Helsinki, Finland

Patrik K. Magnusson

Affiliation Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden

Wendy L. McArdle

Affiliation School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom

Cristina Menni

Affiliation Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom

Sigrun Merger

Affiliation Department of Internal Medicine I, Ulm University Medical Centre, Ulm, Germany

Lili Milani

Affiliation Estonian Genome Center, Univeristy of Tartu, Tartu, Estonia

Grant W. Montgomery

Affiliation QIMR Bergofer Medical Research Institute, Brisbane, Queensland, Australia

Andrew P. Morris

Affiliations Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom, Department of Biostatistics, University of Liverpool, Liverpool, United Kingdom

Narisu Narisu

Affiliation Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, Maryland, United States of America

Mari Nelis

Affiliation Estonian Genome Center, Univeristy of Tartu, Tartu, Estonia

Ken K. Ong

Affiliations MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom, MRC Unit for Lifelong Health & Ageing at UCL, London, United Kingdom, Department of Paediatrics, University of Cambridge, Cambridge, United Kingdom

Aarno Palotie

Affiliations Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland, Wellcome Trust Sanger Institute, Human Genetics, Hinxton, Cambridge, United Kingdom, Massachusetts General Hospital, Center for Human Genetic Research, Psychiatric and Neurodevelopmental Genetics Unit, Boston, Massachusetts, United States of America

Louis Pérusse

Affiliations Department of Kinesiology, Laval University, Québec City, Québec, Canada, Institute of Nutrition and Functional Foods, Laval University, Québec City, Québec, Canada

Irene Pichler

Affiliation Center for Biomedicine, European Academy Bozen/Bolzano (EURAC), Bolzano, Italy, Affiliated Institute of the University of Lübeck, Lübeck, Germany

Maria G. Pilia

Affiliation Istituto di Ricerca Genetica e Biomedica, CNR, Monserrato, Italy

Anneli Pouta

Affiliations Department of Children, Young People and Families, National Institute for Health and Welfare, Helsinki, Finland, Department of Obstetrics and Gynecology, Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland

Myriam Rheinberger

Affiliation Department of Nephrology, University Hospital Regensburg, Regensburg, Germany

Rasmus Ribel-Madsen

Affiliation Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

Marcus Richards

Affiliation MRC Unit for Lifelong Health & Ageing at UCL, London, United Kingdom

Kenneth M. Rice

Affiliation Department of Biostatistics, University of Washington, Seattle, Washington, United States of America

Treva K. Rice

Affiliations Division of Biostatistics, Washington University School of Medicine, St. Louis, Missouri, United States of America, Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, United States of America

Carlo Rivolta

Affiliation Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland

Veikko Salomaa

Affiliation National Institute for Health and Welfare, Department of Chronic Disease Prevention, Helsinki, Finland

Alan R. Sanders

Affiliations NorthShore University HealthSystem, Evanston, Illinois, United States of America, University of Chicago, Chicago, Illinois, United States of America

Mark A. Sarzynski

Affiliation Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana, United States of America

Salome Scholtens

Affiliation University of Groningen, University Medical Center Groningen, Department of Epidemiology, Groningen, The Netherlands

Robert A. Scott

Affiliation MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom

William R. Scott

Affiliations Department of Epidemiology and Biostatistics, Imperial College London, London, United Kingdom, Ealing Hospital NHS Trust, Middlesex, United Kingdom

Sylvain Sebert

Affiliation Institute of Health Sciences, University of Oulu, Oulu, Finland

Sebanti Sengupta

Affiliation Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, United States of America

Bengt Sennblad

Affiliations Atherosclerosis Research Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden, Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden, Science for Life Laboratory, Karolinska Institutet, Stockholm, Sweden

Thomas Seufferlein

Affiliation Department of Internal Medicine I, Ulm University Medical Centre, Ulm, Germany

Angela Silveira

Affiliations Atherosclerosis Research Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden, Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden

P. Eline Slagboom

Affiliation Department of Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands

Jan H. Smit

Affiliation Department of Psychiatry and EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, the Netherlands

Thomas H. Sparsø

Affiliation Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

Kathleen Stirrups

Affiliations Wellcome Trust Sanger Institute, Human Genetics, Hinxton, Cambridge, United Kingdom, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom

Ronald P. Stolk

Affiliation University of Groningen, University Medical Center Groningen, Department of Epidemiology, Groningen, The Netherlands

Heather M. Stringham

Affiliation Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, United States of America

Morris A Swertz

Affiliation University of Groningen, University Medical Center Groningen, Department of Genetics, Groningen, The Netherlands

Amy J. Swift

Affiliation Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, Maryland, United States of America

Ann-Christine Syvänen

Affiliations Science for Life Laboratory, Uppsala University, Uppsala, Sweden, Department of Medical Sciences, Uppsala University, Uppsala, Sweden

Sian-Tsung Tan

Affiliations Ealing Hospital NHS Trust, Middlesex, United Kingdom, National Heart and Lung Institute, Imperial College London, London, United Kingdom

Barbara Thorand

Affiliations Institute of Epidemiology II, Helmholtz Zentrum München—German Research Center for Environmental Health, Neuherberg, Germany, German Center for Diabetes Research (DZD), Neuherberg, Germany

Anke Tönjes

Affiliation University of Leipzig, Department of Medicine, Leipzig, Germany

Angelo Tremblay

Affiliation Department of Kinesiology, Laval University, Québec City, Québec, Canada

Emmanouil Tsafantakis

Affiliation Anogia Medical Centre, Anogia, Greece

Peter J. van der Most

Affiliation University of Groningen, University Medical Center Groningen, Department of Epidemiology, Groningen, The Netherlands

Uwe Völker

Affiliations Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany, DZHK (German Centre for Cardiovascular Research), partner site Greifswald, Greifswald, Germany

Marie-Claude Vohl

Affiliations Institute of Nutrition and Functional Foods, Laval University, Québec City, Québec, Canada, School of Nutrition, Laval University, Québec City, Québec,Canada

Judith M. Vonk

Affiliation University of Groningen, University Medical Center Groningen, Department of Epidemiology, Groningen, The Netherlands

Melanie Waldenberger

Affiliations DZHK (German Centre for Cardiovascular Research), partnersite Munich Heart Alliance, Munich, Germany, Research Unit of Molecular Epidemiology, Helmholtz Zentrum München—German Research Center for Environmental Health, Neuherberg, Germany, Institute of Epidemiology II, Helmholtz Zentrum München—German Research Center for Environmental Health, Neuherberg, Germany

Ryan W. Walker

Affiliations The Charles Bronfman Institute for Personalized Medicine, The Icahn School of Medicine at Mount Sinai, New York, New York, United States of America, The Department of Preventive Medicine, The Icahn School of Medicine at Mount Sinai, New York, New York, United States of America

Roman Wennauer

Affiliation Department of Clinical Chemistry, Ulm University Medical Centre, Ulm, Germany

Elisabeth Widén

Affiliation Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland

Gonneke Willemsen

Affiliation Department of Biological Psychology, VU University, Amsterdam, The Netherlands

Tom Wilsgaard

Affiliations Department of Clinical Medicine, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway, Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway

Alan F. Wright

Affiliation MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, Scotland

M. Carola Zillikens

Affiliations Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), The Netherlands, Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands

Suzanne C. van Dijk

Affiliation Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands

Natasja M. van Schoor

Affiliations EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands, VUMC, Department of Epidemiology and Biostatistics, Amsterdam, The Netherlands

Folkert W. Asselbergs

Affiliations Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht, Netherlands, Durrer Center for Cardiogenetic Research, Interuniversity Cardiology Institute Netherlands-Netherlands Heart Institute, Utrecht, The Netherlands, Institute of Cardiovascular Science, University College London, London, United Kingdom

Paul I. W. de Bakker

Affiliations Department of Medical Genetics, University Medical Center Utrecht, Utrecht, Netherlands, Department of Epidemiology, University Medical Center, Utrecht, The Netherlands

Jacques S. Beckmann

Affiliation Swiss Institute of Bioinformatics, Lausanne, Switzerland

John Beilby

Affiliations Pathwest Laboratory Medicine of Western Australia, Nedlands, Western Australia,Australia, School of Pathology and Laboratory Medicine, University of Western Australia, Nedlands, Western Australia, Australia

David A. Bennett

Affiliation Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, United States of America

Richard N. Bergman

Affiliation Diabetes and Obesity Research Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America

Sven Bergmann

Affiliations Swiss Institute of Bioinformatics, Lausanne, Switzerland, Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland

Carsten A. Böger

Affiliation Department of Nephrology, University Hospital Regensburg, Regensburg, Germany

Bernhard O. Boehm

Affiliations Department of Internal Medicine I, Ulm University Medical Centre, Ulm, Germany, Imperial College London, London, United Kingdom, Lee Kong Chian School of Medicine, Singapore, Singapore, Nanyang Technological University, Singapore, Singapore

Eric Boerwinkle

Affiliation Human Genetics Center and Institute of Molecular Medicine, University of Texas Health Science Center, Houston, Texas, United States of America

Dorret I. Boomsma

Affiliation Department of Biological Psychology, VU University, Amsterdam, The Netherlands

Stefan R. Bornstein

Affiliation Department of Medicine III, University of Dresden, Medical Faculty Carl Gustav Carus, Dresden, Germany

Erwin P. Bottinger

Affiliations The Charles Bronfman Institute for Personalized Medicine, The Icahn School of Medicine at Mount Sinai, New York, New York, United States of America, The Department of Medicine, The Icahn School of Medicine at Mount Sinai, New York, New York, United States of America

Claude Bouchard

Affiliation Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana, United States of America

John C. Chambers

Affiliations Department of Epidemiology and Biostatistics, Imperial College London, London, United Kingdom, Ealing Hospital NHS Trust, Middlesex, United Kingdom, Imperial College Healthcare NHS Trust, London, United Kingdom

Stephen J. Chanock

Affiliations Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America, Program in Biostatistics and Biomathematics, Divison of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

Daniel I. Chasman

Affiliations Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States of America, Harvard Medical School, Boston, Massachusetts,United States of America

Francesco Cucca

Affiliations Istituto di Ricerca Genetica e Biomedica, CNR, Monserrato, Italy, University of Sassari, Sassari, Italy

Daniele Cusi

Affiliations Department of Health Sciences, University of Milan, Milan, Italy, Institute of Biomedical Technologies, National Institute of Research, Segrate-Milano, Italy

George Dedoussis

Affiliation Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, Athens, Greece

Jeanette Erdmann

Affiliations DZHK (German Centre for Cardiovascular Research), partner site Hamburg/Kiel/Lübeck, Lübeck, Germany, Institut für Integrative und Experimentelle Genomik, Universität zu Lübeck, Lübeck, Germany

Johan G. Eriksson

Affiliations National Institute for Health and Welfare, Department of Chronic Disease Prevention, Helsinki, Finland, Folkhälsan Research Centre, Helsinki, Finland, Department of General Practice and Primary Health Care, University of Helsinki, Helsinki, Finland

Denis A. Evans

Affiliation Rush Institute for Healthy Aging and Department of Internal Medicine, Rush University Medical Center, Chicago, Illinois, United States of America

Ulf de Faire

Affiliation Division of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden

Martin Farrall

Affiliations Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom, Division of Cardiovacular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom, Durrer Center for Cardiogenetic Research, Amsterdam, The Netherlands

Luigi Ferrucci

Affiliation Translational Gerontology Branch, National Institute on Aging, Baltimore, Maryland, United States of America

Ian Ford

Affiliation Robertson Center for Biostatistics, University of Glasgow, Glasgow, United Kingdom

Lude Franke

Affiliations University of Groningen, University Medical Center Groningen, Department of Genetics, Groningen, The Netherlands, University of Groningen, University Medical Center Groningen, Department of Cardiology, Groningen, Netherlands

Paul W. Franks

Affiliations Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Skåne University Hospital Malmö, Malmö, Sweden, Department of Public Health & Clinical Medicine, Umeå University Hospital, Umeå, Sweden, Umeå, Sweden, Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, United States of America

Philippe Froguel

Affiliations CNRS UMR 8199, Lille, France, European Genomic Institute for Diabetes, Lille, France, Université de Lille 2, Lille, France

Ron T. Gansevoort

Affiliation University of Groningen, University Medical Center Groningen, Department of Medicine, Groningen, Netherlands

Christian Gieger

Affiliations Research Unit of Molecular Epidemiology, Helmholtz Zentrum München—German Research Center for Environmental Health, Neuherberg, Germany, Institute of Epidemiology II, Helmholtz Zentrum München—German Research Center for Environmental Health, Neuherberg, Germany

Henrik Grönberg

Affiliation Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden

Vilmundur Gudnason

Affiliations Icelandic Heart Association, Kopavogur, Iceland, Faculty of Medicine, University of Iceland, Reykjavik, Iceland

Ulf Gyllensten

Affiliations Science for Life Laboratory, Uppsala University, Uppsala, Sweden, Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden

Per Hall

Affiliation Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden

Anders Hamsten

Affiliations Atherosclerosis Research Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden, Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden, Department of Medicine, Karolinska Institutet, Stockholm, Sweden

Pim van der Harst

Affiliations University of Groningen, University Medical Center Groningen, Department of Genetics, Groningen, The Netherlands, University of Groningen, University Medical Center Groningen, Department of Cardiology, Groningen, Netherlands, Durrer Center for Cardiogenetic Research, Interuniversity Cardiology Institute Netherlands-Netherlands Heart Institute, Utrecht, The Netherlands

Caroline Hayward

Affiliation MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, Scotland

Markku Heliövaara

Affiliation Department of Health, National Institute for Health and Welfare, Helsinki, Finland

Christian Hengstenberg

Affiliations DZHK (German Centre for Cardiovascular Research), partnersite Munich Heart Alliance, Munich, Germany, Deutsches Herzzentrum München, Technische Universität München, München, Germany

Andrew A Hicks

Affiliation Center for Biomedicine, European Academy Bozen/Bolzano (EURAC), Bolzano, Italy, Affiliated Institute of the University of Lübeck, Lübeck, Germany

Aroon Hingorani

Affiliation Institute of Cardiovascular Science, University College London, London, United Kingdom

Albert Hofman

Affiliations Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), The Netherlands, Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands

Frank Hu

Affiliations Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, United States of America, Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

Heikki V. Huikuri

Affiliation Medical Research Center Oulu, Oulu University Hospital, and University of Oulu, Oulu, Finland

Kristian Hveem

Affiliation Department of Public Health and General Practice, Norwegian University of Science and Technology, Trondheim, Norway

Alan L. James

Affiliation Department of Pulmonary Physiology and Sleep Medicine, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia

Joanne M. Jordan

Affiliation Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chaper Hill, North Carolina, United States of America

Antti Jula

Affiliation National Institute for Health and Welfare, Department of Chronic Disease Prevention, Helsinki, Finland

Mika Kähönen

Affiliations Department of Clinical Physiology, Tampere University Hospital, Tampere, Finland, Department of Clinical Physiology, University of Tampere School of Medicine, Tampere, Finland

Eero Kajantie

Affiliations Diabetes Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland, Children's Hospital, Helsinki University Hospital and University of Helsinki, Helsinki, Finland

Sekar Kathiresan

Affiliations Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Cardiovascular Research Center and Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Center for Human Genetics Research, Massachusetts General Hospital, Boston, Massachusetts, United States of America

Lambertus A. L. M. Kiemeney

Affiliations Radboud university medical center, Radboud Institute for Health Sciences, Department for Health Evidence, Nijmegen, The Netherlands, Radboud university medical center, Radboud Institute for Health Sciences, Department of Urology, Nijmegen, The Netherlands

Mika Kivimaki

Affiliation Department of Epidemiology and Public Health, UCL, London, United Kingdom

Paul B. Knekt

Affiliation National Institute for Health and Welfare, Helsinki, Finland

Heikki A. Koistinen

Affiliations National Institute for Health and Welfare, Helsinki, Finland, University of Helsinki and Helsinki University Central Hospital, Department of Medicine and Abdominal Center: Endocrinology, Helsinki, Finland, Minerva Foundation Institute for Medical Research, Helsinki, Finland

Jaspal S. Kooner

Affiliations Ealing Hospital NHS Trust, Middlesex, United Kingdom, National Heart and Lung Institute, Imperial College London, London, United Kingdom, Imperial College Healthcare NHS Trust, London, United Kingdom

Seppo Koskinen

Affiliation Department of Health, National Institute for Health and Welfare, Helsinki, Finland

Johanna Kuusisto

Affiliation Department of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland

Winfried Maerz

Affiliations Vth Department of Medicine, Mannheim Medical Faculty, University of Heidelberg, Mannheim, Germany, Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria

Nicholas G Martin

Affiliation QIMR Bergofer Medical Research Institute, Brisbane, Queensland, Australia

Markku Laakso

Affiliation Department of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland

Timo A. Lakka

Affiliations Kuopio Research Institute of Exercise Medicine, Kuopio, Finland, Department of Physiology, Institute of Biomedicine, University of Eastern Finland, Kuopio Campus, Kuopio, Finland

Terho Lehtimäki

Affiliations Department of Clinical Chemistry, University of Tampere School of Medicine, Tampere, Finland, Department of Clinical Chemistry, Fimlab Laboratories and School of Medicine, University of Tampere, Tampere, Finland

Guillaume Lettre

Affiliations Montreal Heart Institute, Montréal, Québec, Canada, Department of Medicine, Université de Montréal, Montréal, Québec, Canada

Douglas F. Levinson

Affiliation Stanford University, Stanford, California, United States of America

Lars Lind

Affiliation Department of Medical Sciences, Uppsala University, Uppsala, Sweden

Marja-Liisa Lokki

Affiliation Transplantation Laboratory, Haartman Institute, University of Helsinki, Helsinki, Finland

Pekka Mäntyselkä

Affiliations Primary Health Care Unit, Institute of Public Health and Clinical Nutrition, School of Medicine, University of Eastern Finland, Kuopio, Finland, Primary Health Care Unit, Kuopio University Hospital, Kuopio, Finland

Mads Melbye

Affiliations Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark, Department of Medicine, Stanford University School of Medicine, Stanford, California, United States of America

Andres Metspalu

Affiliation Estonian Genome Center, Univeristy of Tartu, Tartu, Estonia

Braxton D. Mitchell

Affiliations University of Maryland School of Medicine, Department of Medicine, Baltimore, Maryland, United States of America, Geriatrics Research and Education Clinical Center, Baltimore Veterans Administration Medical Center, Baltimore, Maryland, United States of America

Frans L. Moll

Affiliation Department of Surgery, University Medical Center Utrecht, Utrecht, Netherlands

Jeffrey C. Murray

Affiliation Department of Pediatrics, University of Iowa, Iowa City, Iowa, United States of America

Arthur W. Musk

Affiliation Department of Respiratory Medicine, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia

Markku S. Nieminen

Affiliation HUCH Heart and Lung Center, Division of Cardiology, Helsinki University Central Hospital, Helsinki, Finland

Inger Njølstad

Affiliations Department of Clinical Medicine, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway, Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway

Claes Ohlsson

Affiliation Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

Albertine J. Oldehinkel

Affiliation University of Groningen, University Medical Center, Interdisciplinary Center Psychopathology and Emotion Regulation, Groningen, The Netherlands

Ben A. Oostra

Affiliation Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands

Lyle J Palmer

Affiliations School of Public Health, University of Adelaide, Adelaide, South Australia, Australia, Robinson Research Institute, University of Adelaide, Adelaide, South Australia, Australia

James S. Pankow

Affiliation Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota, United States of America

Gerard Pasterkamp

Affiliation Experimental Cardiology and laboratory of clinical chemistry, UMCU, Utrecht, The Netherlands

Nancy L. Pedersen

Affiliation Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden

Oluf Pedersen

Affiliation Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

Brenda W. Penninx

Affiliation Department of Psychiatry and EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, the Netherlands

Markus Perola

Affiliations Estonian Genome Center, Univeristy of Tartu, Tartu, Estonia, National Institute for Health and Welfare, Department of Chronic Disease Prevention, Helsinki, Finland, Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland

Annette Peters

Affiliations DZHK (German Centre for Cardiovascular Research), partnersite Munich Heart Alliance, Munich, Germany, Research Unit of Molecular Epidemiology, Helmholtz Zentrum München—German Research Center for Environmental Health, Neuherberg, Germany, Institute of Epidemiology II, Helmholtz Zentrum München—German Research Center for Environmental Health, Neuherberg, Germany

Ozren Polašek

Affiliations Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, Scotland, Department of Public Health, Faculty of Medicine, University of Split, Split, Croatia

Peter P. Pramstaller

Affiliations Center for Biomedicine, European Academy Bozen/Bolzano (EURAC), Bolzano, Italy, Affiliated Institute of the University of Lübeck, Lübeck, Germany, Department of Neurology, General Central Hospital, Bolzano, Italy

Bruce M. Psaty

Affiliations Cardiovascular Health Research Unit, University of Washington, Seattle, Washington, United States of America, Department of Medicine, University of Washington, Seattle, Washington, United States of America, Departments of Epidemiology and Health Services, University of Washington, Seattle, Washington, United States of America, Group Health Research Institute, Group Health Cooperative, Seatte, Washington, United States of America

Lu Qi

Affiliations Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, United States of America, Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

Thomas Quertermous

Affiliation Department of Medicine, Stanford University School of Medicine, Stanford, California, United States of America

Olli T. Raitakari

Affiliations Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland, Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland

Tuomo Rankinen

Affiliation Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana, United States of America

Rainer Rauramaa

Affiliations Kuopio Research Institute of Exercise Medicine, Kuopio, Finland, Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland

Paul M. Ridker

Affiliations Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States of America, Harvard Medical School, Boston, Massachusetts,United States of America

John D. Rioux

Affiliations Montreal Heart Institute, Montréal, Québec, Canada, Department of Medicine, Université de Montréal, Montréal, Québec, Canada

Fernando Rivadeneira

Affiliations Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), The Netherlands, Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands, Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands

Jerome I. Rotter

Affiliation Los Angeles BioMedical Resesarch Institute at Harbor-UCLA Medical Center, Torrance, California, United States of America

Igor Rudan

Affiliation Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, Scotland

Hester M. den Ruijter

Affiliation Experimental Cardiology and laboratory of clinical chemistry, UMCU, Utrecht, The Netherlands

Juha Saltevo

Affiliation Department of Medicine, Central Finland Central Hospital, Jyväskylä, Finland

Naveed Sattar

Affiliation BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, United Kingdom

Heribert Schunkert

Affiliations DZHK (German Centre for Cardiovascular Research), partnersite Munich Heart Alliance, Munich, Germany, Deutsches Herzzentrum München, Technische Universität München, München, Germany

Peter E. H. Schwarz

Affiliation Department of Medicine III, University of Dresden, Medical Faculty Carl Gustav Carus, Dresden, Germany

Alan R. Shuldiner

Affiliations Program for Personalized and Genomic Medicine, Division of Endocrinology, Diabetes & Nutrition, Dept of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, United States of America, Geriatric Research and Education Clinical Center, Vetrans Administration Medical Center, Baltimore, Maryland, United States of America

Juha Sinisalo

Affiliation HUCH Heart and Lung Center, Division of Cardiology, Helsinki University Central Hospital, Helsinki, Finland

Harold Snieder

Affiliation University of Groningen, University Medical Center Groningen, Department of Epidemiology, Groningen, The Netherlands

Thorkild I. A. Sørensen

Affiliations Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark, MRC Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom, Institute of Preventive Medicine, Bispebjerg and Frederiksberg Hospital, The Capital Region, Frederiksberg, Denmark

Tim D. Spector

Affiliation Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom

Jan A. Staessen

Affiliations Research Unit Hypertension and Cardiovascular Epidemiology, KU Leuven Department of Cardiovascular Sciences, University of Leuven, Leuven, Belgium, R & D VitaK Group, Maastricht University, Maastricht, The Netherlands

Bandinelli Stefania

Affiliation Geriatric Unit, Azienda Sanitaria Firenze (ASF), Florence, Italy

Unnur Thorsteinsdottir

Affiliations deCODE Genetics, Amgen inc., Reykjavik, Iceland, Faculty of Medicine, University of Iceland, Reykjavik, Iceland

Michael Stumvoll

Affiliations University of Leipzig, IFB Adiposity Diseases, Leipzig, Germany, University of Leipzig, Department of Medicine, Leipzig, Germany

Jean-Claude Tardif

Affiliations Montreal Heart Institute, Montréal, Québec, Canada, Department of Medicine, Université de Montréal, Montréal, Québec, Canada

Elena Tremoli

Affiliations Centro Cardiologico Monzino, IRCCS, Milan, Italy, Dipartimento di Scienze Farmacologiche e Biomolecolari, Università di Milano, Milan, Italy

Jaakko Tuomilehto

Affiliations Diabetes Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland, Centre for Vascular Prevention, Danube-University Krems, Krems, Austria, Instituto de Investigacion Sanitaria del Hospital Universitario La Paz (IdiPAZ), Madrid, Spain, Diabetes Research Group, King Abdulaziz University, Jeddah, Saudi Arabia

André G. Uitterlinden

Affiliations Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), The Netherlands, Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands, Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands

Matti Uusitupa

Affiliations Department of Public Health and Clinical Nutrition, University of Eastern Finland, Finland, Research Unit, Kuopio University Hospital, Kuopio, Finland

André L. M. Verbeek

Affiliation Radboud university medical center, Radboud Institute for Health Sciences, Department for Health Evidence, Nijmegen, The Netherlands

Sita H. Vermeulen

Affiliations Radboud university medical center, Radboud Institute for Health Sciences, Department for Health Evidence, Nijmegen, The Netherlands, Department of Human Genetics, Radboud university medical center, Nijmegen, The Netherlands

Jorma S. Viikari

Affiliation Department of Medicine, University of Turku, Turku, Finland

Veronique Vitart

Affiliation MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, Scotland

Henry Völzke

Affiliations Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany, DZHK (German Centre for Cardiovascular Research), partner site Greifswald, Greifswald, Germany

Peter Vollenweider

Affiliation Department of Internal Medicine, University Hospital Lausanne (CHUV) and University of Lausanne, Lausanne, Switzerland

Gérard Waeber

Affiliation Department of Internal Medicine, University Hospital Lausanne (CHUV) and University of Lausanne, Lausanne, Switzerland

Mark Walker

Affiliations Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Institute of Cellular Medicine, Newcastle University, Newcastle, United Kingdom

Henri Wallaschofski

Affiliations Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany, DZHK (German Centre for Cardiovascular Research), partner site Greifswald, Greifswald, Germany

Nicholas J. Wareham

Affiliation MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom

Hugh Watkins

Affiliations Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom, Division of Cardiovacular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom

Eleftheria Zeggini

Affiliation Wellcome Trust Sanger Institute, Human Genetics, Hinxton, Cambridge, United Kingdom

CHARGE Consortium

Memberships of CHARGE Consortium, DIAGRAM Consortium, GLGC Consortium, Global-BPGen Consortium, ICBP Consortium, MAGIC Consortium are provided in S2 Text.

Affiliation The Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium

DIAGRAM Consortium

Memberships of CHARGE Consortium, DIAGRAM Consortium, GLGC Consortium, Global-BPGen Consortium, ICBP Consortium, MAGIC Consortium are provided in S2 Text.

Affiliation The DIAbetes Genetics Replication And Meta-analysis Consortium

GLGC Consortium

Memberships of CHARGE Consortium, DIAGRAM Consortium, GLGC Consortium, Global-BPGen Consortium, ICBP Consortium, MAGIC Consortium are provided in S2 Text.

Affiliation The Global Lipids Genetics Consortium

Global-BPGen Consortium

Memberships of CHARGE Consortium, DIAGRAM Consortium, GLGC Consortium, Global-BPGen Consortium, ICBP Consortium, MAGIC Consortium are provided in S2 Text.

Affiliation The Global Blood Pressure Genetics Consortium

ICBP Consortium

Memberships of CHARGE Consortium, DIAGRAM Consortium, GLGC Consortium, Global-BPGen Consortium, ICBP Consortium, MAGIC Consortium are provided in S2 Text.

Affiliation The International Consortium for Blood Pressure

MAGIC Consortium

Memberships of CHARGE Consortium, DIAGRAM Consortium, GLGC Consortium, Global-BPGen Consortium, ICBP Consortium, MAGIC Consortium are provided in S2 Text.

Affiliation The Meta-Analyses of Glucose and Insulin-related traits Consortium

Aravinda Chakravarti

Affiliation Center for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

Deborah J. Clegg

Affiliation Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America

L. Adrienne Cupples

Affiliations National Heart, Lung, and Blood Institute, the Framingham Heart Study, Framingham, Massachusetts, United States of America, Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America

Penny Gordon-Larsen

Affiliations Department of Nutrition, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina, United States of America, Carolina Population Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

Cashell E. Jaquish

Affiliation National Heart, Lung, and Blood Institute, National Institute of Health, Bethesda, Maryland, United States of America

D. C. Rao

Affiliations Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of America, Division of Biostatistics, Washington University School of Medicine, St. Louis, Missouri, United States of America, Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, United States of America

Goncalo R. Abecasis

Affiliation Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, United States of America

Themistocles L. Assimes

Affiliation Department of Medicine, Stanford University School of Medicine, Stanford, California, United States of America

Inês Barroso

Affiliations Wellcome Trust Sanger Institute, Human Genetics, Hinxton, Cambridge, United Kingdom, NIHR Cambridge Biomedical Research Centre, Institute of Metabolic Science Addenbrooke’s Hospital, Cambridge, United Kingdom, University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science Addenbrooke’s Hospital, Cambridge, United Kingdom

Sonja I. Berndt

Affiliation Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America

Michael Boehnke

Affiliation Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, United States of America

Panos Deloukas

Affiliations Wellcome Trust Sanger Institute, Human Genetics, Hinxton, Cambridge, United Kingdom, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom, Princess Al-Jawhara Al-Brahim Centre of Excellence in Research of Hereditary Disorders (PACER-HD), King Abdulaziz University, Jeddah, Saudi Arabia

Caroline S. Fox

Affiliations National Heart, Lung, and Blood Institute, the Framingham Heart Study, Framingham, Massachusetts, United States of America, Harvard Medical School, Boston, Massachusetts,United States of America

Leif C. Groop

Affiliations Lund University Diabetes Centre and Department of Clinical Science, Diabetes & Endocrinology Unit, Lund University, Malmö, Sweden, Finnish Institute for Molecular Medicine (FIMM), Helsinki University, Helsinki, Finland

David J. Hunter

Affiliations Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts, United States of America, Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, United States of America, Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, United States of America, Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America

Erik Ingelsson

Affiliations Science for Life Laboratory, Uppsala University, Uppsala, Sweden, Department of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala, Sweden, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom, Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, California, United States of America

Robert C. Kaplan

Affiliation Department of Epidemiology and Popualtion Health, Albert Einstein College of Medicine, Bronx, New York, United States of America

Mark I. McCarthy

Affiliations Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom, Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, United Kingdom, Oxford NIHR Biomedical Research Centre, Oxford, United Kingdom

Karen L. Mohlke

Affiliation Department of Genetics, University of North Carolina, Chapel Hill, North Carolina, United States of America

Jeffrey R. O'Connell

Affiliation Program for Personalized and Genomic Medicine, Division of Endocrinology, Diabetes & Nutrition, Dept of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, United States of America

David Schlessinger

Affiliation National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America

David P. Strachan

Affiliation Population Health Research Institute, St George's, University of London, London, United Kingdom

Kari Stefansson

Affiliations deCODE Genetics, Amgen inc., Reykjavik, Iceland, Faculty of Medicine, University of Iceland, Reykjavik, Iceland

Cornelia M. van Duijn

Affiliations Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands, Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), The Netherlands, Center for Medical Systems Biology, Leiden, The Netherlands

Joel N. Hirschhorn

Affiliations Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts, United States of America, Divisions of Endocrinology and Genetics and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, Massachusetts, United States of America, Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America

Cecilia M. Lindgren

Affiliations Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts, United States of America, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

Iris M. Heid

iris.heid@klinik.uni-regensburg.de (IMH); kari_north@unc.edu (KEN); iborecki@wustl.edu (IBB); zoltan.kutalik@unil.ch (ZK); Ruth.loos@mssm.edu (RJFL)

‡ These authors jointly supervised this work.

Affiliations Department of Genetic Epidemiology, Institute of Epidemiology and Preventive Medicine, University Regensburg, Regensburg, Germany, Institute of Genetic Epidemiology, Helmholtz Zentrum München—German Research Center for Environmental Health, Neuherberg, Germany

Kari E. North

iris.heid@klinik.uni-regensburg.de (IMH); kari_north@unc.edu (KEN); iborecki@wustl.edu (IBB); zoltan.kutalik@unil.ch (ZK); Ruth.loos@mssm.edu (RJFL)

‡ These authors jointly supervised this work.

Affiliation Carolina Center for Genome Sciences and Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

Ingrid B. Borecki

iris.heid@klinik.uni-regensburg.de (IMH); kari_north@unc.edu (KEN); iborecki@wustl.edu (IBB); zoltan.kutalik@unil.ch (ZK); Ruth.loos@mssm.edu (RJFL)

‡ These authors jointly supervised this work.

Affiliation Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of America

Zoltán Kutalik

iris.heid@klinik.uni-regensburg.de (IMH); kari_north@unc.edu (KEN); iborecki@wustl.edu (IBB); zoltan.kutalik@unil.ch (ZK); Ruth.loos@mssm.edu (RJFL)

‡ These authors jointly supervised this work.

Affiliations Swiss Institute of Bioinformatics, Lausanne, Switzerland, Institute of Social and Preventive Medicine, University Hospital Lausanne (CHUV), Lausanne, Switzerland, Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland

Ruth J. F. Loos

iris.heid@klinik.uni-regensburg.de (IMH); kari_north@unc.edu (KEN); iborecki@wustl.edu (IBB); zoltan.kutalik@unil.ch (ZK); Ruth.loos@mssm.edu (RJFL)

‡ These authors jointly supervised this work.

Affiliations MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom, The Charles Bronfman Institute for Personalized Medicine, The Icahn School of Medicine at Mount Sinai, New York, New York, United States of America, The Department of Preventive Medicine, The Icahn School of Medicine at Mount Sinai, New York, New York, United States of America, The Genetics of Obesity and Related Metabolic Traits Program, The Icahn School of Medicine at Mount Sinai, New York, New York, United States of America, The Mindich Child Health and Development Institute, The Icahn School of Medicine at Mount Sinai, New York, New York, United States of America

Competing Interests

I have read the journals policy and we have the following conflicts: KSte, UT, VSte and GT are employed by deCODE Genetics/Amgen inc. IB and spouse own stock in Incyte Ltd and GlaxoSmithKline. JMJ serves as consultant for Trinity Partners, Inc., Samumed, Flexion, and is deputy editor for Osteoarthritis & Cartilage and serves on board of directors of American College of Rheumatology. PV and GWa received an unresticted grant from GlaxoSmithKline to build the CoLaus study. BMP serves on the data and safety monitoring board (DSMB) for a clinical trial of a device funded by the manufacturer (Zoll LifeCor) and serves on the Steering Committee of the Yale Open Data Access Project funded by Johnson & Johnson.

Author Contributions

Conceived and designed the experiments: IBB IMH KEN RJFL TWW ZK. Performed the experiments: AEJ LBa MGr TWW ZK. Analyzed the data: AEJ LBa MGr RM TWW ZK. Contributed reagents/materials/analysis tools: AEJ LBa MGr TWW ZK. Wrote the paper: AEJ IBB IMH KEN LBa MGr MFF RJFL TWW ZK. Contributed genome-wide association study results: AAH AB ACA ACHa ACHe ACS AD AEF AEJ AFW AG AGU AHa AHo AJ ÅJ AJMdC AJO AJS AKH ALJ ALMV AMa AMe APa APe APM APo ARSa ARSh ASB ASG ASt ATe ATH ATö ATr AUJ AVS AWM BAO BDM BF BL BMK BMP BOB BSt BT BWP CAB CAH CBa CBe CBo CG CHa CHe CLang CM CMG CML CMvD CO CR CSF CW CWKC DA DAB DAE DC DCR DFL DH DIB DIC DJH DPS DS EA EB EE EI EJCdG EK EM EPB ETs EV EW EZ FB FC FF FG FH FLM FRe FRiv FRiz FSC FWA GB GC GDed GDel GE GL GM GP GRA GT GWa GWi GWM HAB HAK HC HGra HGrö HH HMdR HMS HScha HSchu HSn HV HVH HWal HWat IB IBB IF IK IMH IML IMN IN IPi IPr IR IT JAS JBe JBl JCB JCC JCM JCo JCT JCz JD JDR JEH JErd JEri JFW JG JGE JH JHS JHZ JIR JJH JKr JKu JLa JLBG JLu JMJ JMV JNH JPT JROC JSB JSh JSin JSK JSP JSV JT JvS JVvVO JWJ JY KAR KBJ KEN KKO KLMoh KLMon KMR KP KSL KSte KSti KTK LAC LALMK LBa LBr LCG LCPGMdG LFe LJL LJP LK LLa LLi LLW LM LMR LMYA LPas LPat LPé LQ LS LV LYe LYu MASa MASw MBa MBl MBo MBr MCV MCZ MD MEK MEM MF MFF MGo MGP MGr MHa MHe MJ MKä MKaa MKar MLa MLL MLo MMa MMe MN MP MRh MS MSN MWald MWalk ND NE NF NGl NGM NH NHK NJW NLHC NLP NMvS NP NS NV NvdV NWR OG OPo OTR PAFM PB PBK PD PEHS PES PF PGH PH PIWdB PJvdM PK PKM PLdJ PMR PPP PS PSC PV PvdH PVG PWF RAS RJFL RL RM RNB RPS RR RTG RWW SA SB SCvD SE SG SH SHV SHW SIB SJ SJC SJK SJLB SKan SKat SKo SL SMä SRB SRW SSa SSc SSeb ST STT SWvdL TAL TBG TBH TDS TE TEG TFa TH TIAS TK TKR TL TLA TMT TQ TR TSA TT TW UG UT UV VG VLo VLy VSa VSt VV WLMA WM WRS WZ YCC YDIC YJS YLi YLu YMG YPL ZK ZW. Contributed Metabochip association study results: AB AHa AHi AL AMe ASi AW BG BOB BSe CLang CLanz DB DK EAA EE EI EM ETr FB FRe IB IMH JHZ JLi JLu JSa KB KF KGH KH KKO KL KSti KTK LLB LLH LM LYe MGo MKi MKu MMN MRi MU NGF NGr NJW NLP NN NTK OH OPe PD PF PM PWF RAS RJFL RJS RL RRM RW SA SCB SKan SL SMe TE TFa TH THS TI TJ TS TSA TWW UdF WKo WKr. Contributed SNP look-up data: AC CCW CEJ DCR GBE IPr JSim LAC NLHC RM SSen TFe VLa. Performed Study-specific GCTA analyses: ATe MGr SR TE TWW ZK. Performed study-specific quality control: AEJ JCz LBa MFF MGr RM SC TE TFa TOK TWW YLu ZK. Performed DEPICT Gene Pathway analyses: JKa JNH LFr THP. Performed IPA Gene Pathway analyses: AEJ. Performed Expression Quantitative trait loci (eQTL) analyses: HJW LFr RJ TE. Performed Mouse microarray expression analyses: DJC MDN. Contributed Look-up information and analyses for young adults ages 16–25 years: KEN LAC MGr PGL SIB. GIANT Steering committee: CMvD CSF DJH DPS DS EI GRA IB IBB IMH JNH JROC KEN KLMoh LCG MBo MIMC PD RCK RJFL SIB TLA UT.