About the Authors

Natalie J. Prescott

natalie.prescott@kcl.ac.uk

‡ NJP and BL contributed equally to this work. MEW, TS, and CGM also contributed equally to this work.

Affiliation Department of Medical and Molecular Genetics, Kings College London, Guy’s Hospital, London, United Kingdom

Benjamin Lehne

‡ NJP and BL contributed equally to this work. MEW, TS, and CGM also contributed equally to this work.

Affiliations Department of Medical and Molecular Genetics, Kings College London, Guy’s Hospital, London, United Kingdom, Department of Epidemiology and Biostatistics, Imperial College London, London, United Kingdom

Kristina Stone

Affiliation Department of Medical and Molecular Genetics, Kings College London, Guy’s Hospital, London, United Kingdom

James C. Lee

Affiliation Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, Cambridge, United Kingdom

Kirstin Taylor

Affiliation Department of Medical and Molecular Genetics, Kings College London, Guy’s Hospital, London, United Kingdom

Jo Knight

Affiliations Department of Medical and Molecular Genetics, Kings College London, Guy’s Hospital, London, United Kingdom, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada, Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada

Efterpi Papouli

Affiliation NIHR GSTFT/KCL Comprehensive Biomedical Research Centre Genomics Core Facility, King’s College London School of Medicine, Guy’s Hospital, London, United Kingdom

Muddassar M. Mirza

Affiliation NIHR GSTFT/KCL Comprehensive Biomedical Research Centre Genomics Core Facility, King’s College London School of Medicine, Guy’s Hospital, London, United Kingdom

Michael A. Simpson

Affiliation Department of Medical and Molecular Genetics, Kings College London, Guy’s Hospital, London, United Kingdom

Sarah L. Spain

Affiliation Department of Medical and Molecular Genetics, Kings College London, Guy’s Hospital, London, United Kingdom

Grace Lu

Affiliation Randall Division of Cell and Molecular Biophysics, King’s College London, Guy’s Campus, London, United Kingdom

Franca Fraternali

Affiliation Randall Division of Cell and Molecular Biophysics, King’s College London, Guy’s Campus, London, United Kingdom

Suzannah J. Bumpstead

Affiliation Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom

Emma Gray

Affiliation Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom

Ariella Amar

Affiliation Department of Medical and Molecular Genetics, Kings College London, Guy’s Hospital, London, United Kingdom

Hannah Bye

Affiliation Department of Medical and Molecular Genetics, Kings College London, Guy’s Hospital, London, United Kingdom

Peter Green

Affiliation Department of Medical and Molecular Genetics, Kings College London, Guy’s Hospital, London, United Kingdom

Guy Chung-Faye

Affiliation Department of Gastroenterology, King’s College Hospital NHS Foundation Trust, Denmark Hill, London, United Kingdom

Bu’Hussain Hayee

Affiliation Department of Gastroenterology, King’s College Hospital NHS Foundation Trust, Denmark Hill, London, United Kingdom

Richard Pollok

Affiliation Gastroenterology and Hepatology, St George’s Healthcare NHS Trust, Tooting, London, United Kingdom

Jack Satsangi

Affiliation Gastrointestinal Unit, Molecular Medicine Centre, University of Edinburgh, Western General Hospital, Edinburgh, United Kingdom

Miles Parkes

Affiliation Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, Cambridge, United Kingdom

Jeffrey C. Barrett

Affiliation Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom

John C. Mansfield

Affiliation Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom

Jeremy Sanderson

Affiliation Guy’s & St Thomas’ NHS Foundation Trust, St Thomas’ Hospital, Department of Gastroenterology, London, United Kingdom

Cathryn M. Lewis

Affiliation Department of Medical and Molecular Genetics, Kings College London, Guy’s Hospital, London, United Kingdom

Michael E. Weale

‡ NJP and BL contributed equally to this work. MEW, TS, and CGM also contributed equally to this work.

Affiliation Department of Medical and Molecular Genetics, Kings College London, Guy’s Hospital, London, United Kingdom

Thomas Schlitt

‡ NJP and BL contributed equally to this work. MEW, TS, and CGM also contributed equally to this work.

Affiliation Department of Medical and Molecular Genetics, Kings College London, Guy’s Hospital, London, United Kingdom

Christopher G. Mathew

‡ NJP and BL contributed equally to this work. MEW, TS, and CGM also contributed equally to this work.

Affiliations Department of Medical and Molecular Genetics, Kings College London, Guy’s Hospital, London, United Kingdom, Division of Medical Biochemistry, University of Cape Town, Cape Town, South Africa

UK IBD Genetics Consortium

Membership of the UK IBD Genetics Consortium is listed in the Acknowledgments.

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: PG CML CGM NJP TS MEW. Performed the experiments: NJP KS MMM EP AA SJB HB EG. Analyzed the data: BL TS MEW NJP SLS. Contributed reagents/materials/analysis tools: BL MAS JCB. Wrote the paper: BL CGM NJP MEW. Candidate gene selection: JK BL CML CGM NJP. Targeted capture design: PG BL NJP TS. Study subject recruitment and phenotyping: JCL KT JCM MP JSat JSan GCF BH RP. Project management CGM TS MEW. Structural predictions for IL12B mutations: GL FF.