About the Authors
- Natalie J. Prescott
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* E-mail: natalie.prescott@kcl.ac.uk
¶‡ NJP and BL contributed equally to this work. MEW, TS, and CGM also contributed equally to this work.
Affiliation Department of Medical and Molecular Genetics, Kings College London, Guy’s Hospital, London, United Kingdom
- Benjamin Lehne
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¶‡ NJP and BL contributed equally to this work. MEW, TS, and CGM also contributed equally to this work.
Affiliations Department of Medical and Molecular Genetics, Kings College London, Guy’s Hospital, London, United Kingdom, Department of Epidemiology and Biostatistics, Imperial College London, London, United Kingdom
- Kristina Stone
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Affiliation Department of Medical and Molecular Genetics, Kings College London, Guy’s Hospital, London, United Kingdom
- James C. Lee
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Affiliation Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, Cambridge, United Kingdom
- Kirstin Taylor
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Affiliation Department of Medical and Molecular Genetics, Kings College London, Guy’s Hospital, London, United Kingdom
- Jo Knight
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Affiliations Department of Medical and Molecular Genetics, Kings College London, Guy’s Hospital, London, United Kingdom, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada, Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
- Efterpi Papouli
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Affiliation NIHR GSTFT/KCL Comprehensive Biomedical Research Centre Genomics Core Facility, King’s College London School of Medicine, Guy’s Hospital, London, United Kingdom
- Muddassar M. Mirza
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Affiliation NIHR GSTFT/KCL Comprehensive Biomedical Research Centre Genomics Core Facility, King’s College London School of Medicine, Guy’s Hospital, London, United Kingdom
- Michael A. Simpson
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Affiliation Department of Medical and Molecular Genetics, Kings College London, Guy’s Hospital, London, United Kingdom
- Sarah L. Spain
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Affiliation Department of Medical and Molecular Genetics, Kings College London, Guy’s Hospital, London, United Kingdom
- Grace Lu
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Affiliation Randall Division of Cell and Molecular Biophysics, King’s College London, Guy’s Campus, London, United Kingdom
- Franca Fraternali
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Affiliation Randall Division of Cell and Molecular Biophysics, King’s College London, Guy’s Campus, London, United Kingdom
- Suzannah J. Bumpstead
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Affiliation Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom
- Emma Gray
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Affiliation Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom
- Ariella Amar
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Affiliation Department of Medical and Molecular Genetics, Kings College London, Guy’s Hospital, London, United Kingdom
- Hannah Bye
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Affiliation Department of Medical and Molecular Genetics, Kings College London, Guy’s Hospital, London, United Kingdom
- Peter Green
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Affiliation Department of Medical and Molecular Genetics, Kings College London, Guy’s Hospital, London, United Kingdom
- Guy Chung-Faye
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Affiliation Department of Gastroenterology, King’s College Hospital NHS Foundation Trust, Denmark Hill, London, United Kingdom
- Bu’Hussain Hayee
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Affiliation Department of Gastroenterology, King’s College Hospital NHS Foundation Trust, Denmark Hill, London, United Kingdom
- Richard Pollok
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Affiliation Gastroenterology and Hepatology, St George’s Healthcare NHS Trust, Tooting, London, United Kingdom
- Jack Satsangi
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Affiliation Gastrointestinal Unit, Molecular Medicine Centre, University of Edinburgh, Western General Hospital, Edinburgh, United Kingdom
- Miles Parkes
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Affiliation Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, Cambridge, United Kingdom
- Jeffrey C. Barrett
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Affiliation Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom
- John C. Mansfield
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Affiliation Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom
- Jeremy Sanderson
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Affiliation Guy’s & St Thomas’ NHS Foundation Trust, St Thomas’ Hospital, Department of Gastroenterology, London, United Kingdom
- Cathryn M. Lewis
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Affiliation Department of Medical and Molecular Genetics, Kings College London, Guy’s Hospital, London, United Kingdom
- Michael E. Weale
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¶‡ NJP and BL contributed equally to this work. MEW, TS, and CGM also contributed equally to this work.
Affiliation Department of Medical and Molecular Genetics, Kings College London, Guy’s Hospital, London, United Kingdom
- Thomas Schlitt
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¶‡ NJP and BL contributed equally to this work. MEW, TS, and CGM also contributed equally to this work.
Affiliation Department of Medical and Molecular Genetics, Kings College London, Guy’s Hospital, London, United Kingdom
- Christopher G. Mathew
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¶‡ NJP and BL contributed equally to this work. MEW, TS, and CGM also contributed equally to this work.
Affiliations Department of Medical and Molecular Genetics, Kings College London, Guy’s Hospital, London, United Kingdom, Division of Medical Biochemistry, University of Cape Town, Cape Town, South Africa
- UK IBD Genetics Consortium
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¶Membership of the UK IBD Genetics Consortium is listed in the Acknowledgments.
Competing Interests
The authors have declared that no competing interests exist.
Author Contributions
Conceived and designed the experiments: PG CML CGM NJP TS MEW. Performed the experiments: NJP KS MMM EP AA SJB HB EG. Analyzed the data: BL TS MEW NJP SLS. Contributed reagents/materials/analysis tools: BL MAS JCB. Wrote the paper: BL CGM NJP MEW. Candidate gene selection: JK BL CML CGM NJP. Targeted capture design: PG BL NJP TS. Study subject recruitment and phenotyping: JCL KT JCM MP JSat JSan GCF BH RP. Project management CGM TS MEW. Structural predictions for IL12B mutations: GL FF.