About the Authors

Aenne S. Thormaehlen

Contributed equally to this work with: Aenne S. Thormaehlen, Rainer Pepperkok

Affiliations Institute of Human Genetics, University of Heidelberg, Heidelberg, Germany, Molecular Medicine Partnership Unit (MMPU), University of Heidelberg/ EMBL, Heidelberg, Germany

Christian Schuberth

Affiliations Institute of Human Genetics, University of Heidelberg, Heidelberg, Germany, Molecular Medicine Partnership Unit (MMPU), University of Heidelberg/ EMBL, Heidelberg, Germany

Hong-Hee Won

Affiliations Center of Human Genetic Research (CHGR), Massachusetts General Hospital, Boston, Massachusetts, United States of America, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America, Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America

Peter Blattmann

Affiliations Molecular Medicine Partnership Unit (MMPU), University of Heidelberg/ EMBL, Heidelberg, Germany, Cell Biology/Biophysics Unit, European Molecular Biological Laboratory, Heidelberg, Germany

Brigitte Joggerst-Thomalla

Affiliations Institute of Human Genetics, University of Heidelberg, Heidelberg, Germany, Molecular Medicine Partnership Unit (MMPU), University of Heidelberg/ EMBL, Heidelberg, Germany

Susanne Theiss

Affiliation Institute of Human Genetics, University of Heidelberg, Heidelberg, Germany

Rosanna Asselta

Affiliation Humanitas University, Milan, Italy

Stefano Duga

Affiliation Humanitas University, Milan, Italy

Pier Angelica Merlini

Affiliation Division of Cardiology, Ospedale Niguarda, Milan, Italy

Diego Ardissino

Affiliation Department of Cardiology, Parma Hospital, Parma, Italy

Eric S. Lander

Affiliation Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America

Stacey Gabriel

Affiliation Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America

Daniel J. Rader

Affiliation Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

Gina M. Peloso

Affiliations Center of Human Genetic Research (CHGR), Massachusetts General Hospital, Boston, Massachusetts, United States of America, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America

Rainer Pepperkok

Contributed equally to this work with: Aenne S. Thormaehlen, Rainer Pepperkok

Affiliations Molecular Medicine Partnership Unit (MMPU), University of Heidelberg/ EMBL, Heidelberg, Germany, Cell Biology/Biophysics Unit, European Molecular Biological Laboratory, Heidelberg, Germany

Sekar Kathiresan

‡ These author’s contributed equally to this work

Affiliations Center of Human Genetic Research (CHGR), Massachusetts General Hospital, Boston, Massachusetts, United States of America, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America, Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Division of Cardiology, Ospedale Niguarda, Milan, Italy

Heiko Runz

heiko.runz@merck.com

Current address: Department of Genetics and Pharmacogenomics, Merck Research Laboratories, Boston, Massachusetts, United States of America

‡ These author’s contributed equally to this work

Affiliations Institute of Human Genetics, University of Heidelberg, Heidelberg, Germany, Molecular Medicine Partnership Unit (MMPU), University of Heidelberg/ EMBL, Heidelberg, Germany, Center of Human Genetic Research (CHGR), Massachusetts General Hospital, Boston, Massachusetts, United States of America, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America

Competing Interests

I have read the journal’s policy and the authors of this manuscript have the following competing interests: HR is an employee of Merck & Co. Beyond that, the authors declare no competing financial interests.

Author Contributions

Conceived and designed the experiments: HR RP SK. Performed the experiments: AST CS PB BJT ST. Analyzed the data: AST CS HHW GMP HR. Contributed reagents/materials/analysis tools: HHW SD PAM RA DA ESL SG DJR GMP SK. Wrote the paper: AST HR. Coordinated the study: HR.