Loss of Trabid, a New Negative Regulator of the Drosophila Immune-Deficiency Pathway at the Level of TAK1, Reduces Life Span

Merennege Dilan Anush Fernando; Ilias Kounatidis; Petros Ligoxygakis

doi:10.1371/journal.pgen.1004117

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Peer-reviewed

Research Article

Loss of Trabid, a New Negative Regulator of the Drosophila Immune-Deficiency Pathway at the Level of TAK1, Reduces Life Span

Merennege Dilan Anush Fernando ,

Contributed equally to this work with: Merennege Dilan Anush Fernando, Ilias Kounatidis

Affiliation Genes and Development Laboratory, Department of Biochemistry, University of Oxford, Oxford, United Kingdom
⨯
Ilias Kounatidis ,

Contributed equally to this work with: Merennege Dilan Anush Fernando, Ilias Kounatidis

Affiliation Genes and Development Laboratory, Department of Biochemistry, University of Oxford, Oxford, United Kingdom
⨯
Petros Ligoxygakis

* E-mail: petros.ligoxygakis@bioch.ox.ac.uk

Affiliation Genes and Development Laboratory, Department of Biochemistry, University of Oxford, Oxford, United Kingdom
⨯

Loss of Trabid, a New Negative Regulator of the Drosophila Immune-Deficiency Pathway at the Level of TAK1, Reduces Life Span

Merennege Dilan Anush Fernando,
Ilias Kounatidis,
Petros Ligoxygakis

Published: February 20, 2014
https://doi.org/10.1371/journal.pgen.1004117

About the Authors

Merennege Dilan Anush Fernando

Contributed equally to this work with: Merennege Dilan Anush Fernando, Ilias Kounatidis

Affiliation Genes and Development Laboratory, Department of Biochemistry, University of Oxford, Oxford, United Kingdom

Ilias Kounatidis

Contributed equally to this work with: Merennege Dilan Anush Fernando, Ilias Kounatidis

Affiliation Genes and Development Laboratory, Department of Biochemistry, University of Oxford, Oxford, United Kingdom

Petros Ligoxygakis

* E-mail: petros.ligoxygakis@bioch.ox.ac.uk

Affiliation Genes and Development Laboratory, Department of Biochemistry, University of Oxford, Oxford, United Kingdom

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: PL MDAF IK. Performed the experiments: MDAF IK PL. Analyzed the data: PL IK MDAF. Contributed reagents/materials/analysis tools: MDAF PL. Wrote the paper: MDAF IK PL.

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Drosophila melanogaster
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Ubiquitination
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Immunoprecipitation
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Transfection
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Point mutation
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SDS polyacrylamide gel electrophoresis
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Transcription factors
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Zinc finger domains
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