About the Authors

Ricardo Mouro Pinto

Affiliation Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, United States of America

Ella Dragileva

Affiliation Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, United States of America

Andrew Kirby

Affiliations Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America

Alejandro Lloret

Affiliation Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, United States of America

Edith Lopez

Affiliation Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, United States of America

Jason St. Claire

Affiliation Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, United States of America

Gagan B. Panigrahi

Affiliations Program of Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Canada, Department of Molecular Genetics, University of Toronto, Toronto, Canada

Caixia Hou

Affiliation Graduate Center for Toxicology and Markey Cancer Center, University of Kentucky College of Medicine, Lexington, Kentucky, United States of America

Kim Holloway

Affiliation Department of Biomedical Sciences, Cornell University, Ithaca, New York, United States of America

Tammy Gillis

Affiliation Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, United States of America

Jolene R. Guide

Affiliation Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, United States of America

Paula E. Cohen

Affiliation Department of Biomedical Sciences, Cornell University, Ithaca, New York, United States of America

Guo-Min Li

Affiliation Graduate Center for Toxicology and Markey Cancer Center, University of Kentucky College of Medicine, Lexington, Kentucky, United States of America

Christopher E. Pearson

Affiliations Program of Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Canada, Department of Molecular Genetics, University of Toronto, Toronto, Canada

Mark J. Daly

Affiliations Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America

Vanessa C. Wheeler

wheeler@chgr.mgh.harvard.edu

Affiliation Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: RMP AK KH PEC GML CEP MJD VCW. Performed the experiments: RMP ED AK AL EL JSC GBP CH KH TG JRG. Analyzed the data: RMP ED AK AL JSC GBP CH TG GML CEP MJD VCW. Contributed reagents/materials/analysis tools: AK MJD KH PEC. Wrote the paper: RMP GML CEP VCW.