The Transcription Factors Sox10 and Myrf Define an Essential Regulatory Network Module in Differentiating Oligodendrocytes

Julia Hornig; Franziska Fröb; Michael R. Vogl; Irm Hermans-Borgmeyer; Ernst R. Tamm; Michael Wegner

doi:10.1371/journal.pgen.1003907

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Open Access

Peer-reviewed

Research Article

The Transcription Factors Sox10 and Myrf Define an Essential Regulatory Network Module in Differentiating Oligodendrocytes

Julia Hornig ,

Contributed equally to this work with: Julia Hornig, Franziska Fröb

Affiliation Institut für Biochemie, Emil-Fischer-Zentrum, Universität Erlangen-Nürnberg, Erlangen, Germany
⨯
Franziska Fröb ,

Contributed equally to this work with: Julia Hornig, Franziska Fröb

Affiliation Institut für Biochemie, Emil-Fischer-Zentrum, Universität Erlangen-Nürnberg, Erlangen, Germany
⨯
Michael R. Vogl,

Affiliation Institut für Biochemie, Emil-Fischer-Zentrum, Universität Erlangen-Nürnberg, Erlangen, Germany
⨯
Irm Hermans-Borgmeyer,

Affiliation ZMNH, Universitätsklinikum Eppendorf, Hamburg, Germany
⨯
Ernst R. Tamm,

Affiliation Institut für Humananatomie und Embryologie, Universität Regensburg, Regensburg, Germany
⨯
Michael Wegner

* E-mail: m.wegner@biochem.uni-erlangen.de

Affiliation Institut für Biochemie, Emil-Fischer-Zentrum, Universität Erlangen-Nürnberg, Erlangen, Germany
⨯

The Transcription Factors Sox10 and Myrf Define an Essential Regulatory Network Module in Differentiating Oligodendrocytes

Julia Hornig,
Franziska Fröb,
Michael R. Vogl,
Irm Hermans-Borgmeyer,
Ernst R. Tamm,
Michael Wegner

Published: October 31, 2013
https://doi.org/10.1371/journal.pgen.1003907

About the Authors

Julia Hornig

Contributed equally to this work with: Julia Hornig, Franziska Fröb

Affiliation Institut für Biochemie, Emil-Fischer-Zentrum, Universität Erlangen-Nürnberg, Erlangen, Germany

Franziska Fröb

Contributed equally to this work with: Julia Hornig, Franziska Fröb

Affiliation Institut für Biochemie, Emil-Fischer-Zentrum, Universität Erlangen-Nürnberg, Erlangen, Germany

Michael R. Vogl

Affiliation Institut für Biochemie, Emil-Fischer-Zentrum, Universität Erlangen-Nürnberg, Erlangen, Germany

Irm Hermans-Borgmeyer

Affiliation ZMNH, Universitätsklinikum Eppendorf, Hamburg, Germany

Ernst R. Tamm

Affiliation Institut für Humananatomie und Embryologie, Universität Regensburg, Regensburg, Germany

Michael Wegner

* E-mail: m.wegner@biochem.uni-erlangen.de

Affiliation Institut für Biochemie, Emil-Fischer-Zentrum, Universität Erlangen-Nürnberg, Erlangen, Germany

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JH FF MW. Performed the experiments: JH FF MRV ERT. Analyzed the data: JH FF ERT MW. Contributed reagents/materials/analysis tools: IHB. Wrote the paper: JH MW.

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Spinal cord
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Cell differentiation
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Transcription factors
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Central nervous system
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Gene expression
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Schwann cells
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Oligonucleotides
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Transfection
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