Correlated Occurrence and Bypass of Frame-Shifting Insertion-Deletions (InDels) to Give Functional Proteins

Liat Rockah-Shmuel; Ágnes Tóth-Petróczy; Asaf Sela; Omri Wurtzel; Rotem Sorek; Dan S. Tawfik

doi:10.1371/journal.pgen.1003882

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Open Access

Peer-reviewed

Research Article

Correlated Occurrence and Bypass of Frame-Shifting Insertion-Deletions (InDels) to Give Functional Proteins

Liat Rockah-Shmuel,

Affiliation Department of Biological Chemistry, Weizmann Institute of Science, Rehovot, Israel
⨯
Ágnes Tóth-Petróczy,

Affiliation Department of Biological Chemistry, Weizmann Institute of Science, Rehovot, Israel
⨯
Asaf Sela,

Affiliation Department of Biological Chemistry, Weizmann Institute of Science, Rehovot, Israel
⨯
Omri Wurtzel,

Affiliation Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
⨯
Rotem Sorek,

Affiliation Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
⨯
Dan S. Tawfik

* E-mail: tawfik@weizmann.ac.il

Affiliation Department of Biological Chemistry, Weizmann Institute of Science, Rehovot, Israel
⨯

Correlated Occurrence and Bypass of Frame-Shifting Insertion-Deletions (InDels) to Give Functional Proteins

Liat Rockah-Shmuel,
Ágnes Tóth-Petróczy,
Asaf Sela,
Omri Wurtzel,
Rotem Sorek,
Dan S. Tawfik

Published: October 24, 2013
https://doi.org/10.1371/journal.pgen.1003882

About the Authors

Liat Rockah-Shmuel

Affiliation Department of Biological Chemistry, Weizmann Institute of Science, Rehovot, Israel

Ágnes Tóth-Petróczy

Affiliation Department of Biological Chemistry, Weizmann Institute of Science, Rehovot, Israel

Asaf Sela

Affiliation Department of Biological Chemistry, Weizmann Institute of Science, Rehovot, Israel

Omri Wurtzel

Affiliation Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel

Rotem Sorek

Affiliation Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel

Dan S. Tawfik

* E-mail: tawfik@weizmann.ac.il

Affiliation Department of Biological Chemistry, Weizmann Institute of Science, Rehovot, Israel

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: LRS DST. Performed the experiments: LRS AS. Analyzed the data: LRS ÁTP OW RS. Contributed reagents/materials/analysis tools: LRS ÁTP OW RS. Wrote the paper: LRS DST.

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Point mutation
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Plasmid construction
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Nucleotides
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Mutagenesis
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DNA methylation
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Sequence alignment
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Methylation
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Polymerase chain reaction
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