About the Authors

Leonardo Bottolo

Contributed equally to this work with: Leonardo Bottolo, Marc Chadeau-Hyam

l.bottolo@imperial.ac.uk (LB); sylvia@mrc-bsu.cam.ac.uk (SR)

Affiliation Department of Mathematics, Imperial College London, London, United Kingdom

Marc Chadeau-Hyam

Contributed equally to this work with: Leonardo Bottolo, Marc Chadeau-Hyam

Affiliation Department of Epidemiology and Biostatistics, Imperial College London, London, United Kingdom

David I. Hastie

Affiliation Department of Epidemiology and Biostatistics, Imperial College London, London, United Kingdom

Tanja Zeller

Affiliation University Heart Center Hamburg, Department of General and Interventional Cardiology, Hamburg, Germany

Benoit Liquet

Affiliations INSERM U897, University Victor Segalen, Bordeaux, France, MRC Biostatistics Unit, Institute of Public Health, Cambridge, United Kingdom

Paul Newcombe

Affiliation MRC Biostatistics Unit, Institute of Public Health, Cambridge, United Kingdom

Loic Yengo

Affiliations European Genomic Institute for Diabetes, Lille, France, CNRS UMR 8199 - Institut Pasteur de Lille, Lille, France

Philipp S. Wild

Affiliation Clinical Epidemiology, Center for Thrombosis and Haemostasis, University Medical Center Mainz, Mainz, Germany

Arne Schillert

Affiliation Institute of Medical Biometry and Statistics, University of Lübeck, Lübeck, Germany

Andreas Ziegler

Affiliation Institute of Medical Biometry and Statistics, University of Lübeck, Lübeck, Germany

Sune F. Nielsen

Affiliations Department of Clinical Biochemistry, Herlev Hospital, Copenhagen, Denmark, Copenhagen University Hospital, University of Copenhagen, Copenhagen, Denmark

Adam S. Butterworth

Affiliation Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom

Weang Kee Ho

Affiliation Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom

Raphaële Castagné

Affiliation INSERM UMRS 937, Pierre and Marie Curie University (UPMC, Paris 6), Paris, France

Thomas Munzel

Affiliation Department of Medicine II, University Medical Center Mainz, Mainz, Germany

David Tregouet

Affiliation Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom

Mario Falchi

Affiliation Department of Genomics of Common Disease, School Of Public Health, Hammersmith Hospital, Imperial College London, London, United Kingdom

François Cambien

Affiliation INSERM UMRS 937, Pierre and Marie Curie University (UPMC, Paris 6), Paris, France

Børge G. Nordestgaard

Affiliations Department of Clinical Biochemistry, Herlev Hospital, Copenhagen, Denmark, Copenhagen University Hospital, University of Copenhagen, Copenhagen, Denmark

Fredéric Fumeron

Affiliations INSERM U695, Paris, France, Université Paris Diderot-Paris 7, UFR de Médecine Site Bichat, Paris, France

Anne Tybjærg-Hansen

Affiliation Copenhagen University Hospital, University of Copenhagen, Copenhagen, Denmark

Philippe Froguel

Affiliations European Genomic Institute for Diabetes, Lille, France, CNRS UMR 8199 - Institut Pasteur de Lille, Lille, France, Department of Genomics of Common Disease, School Of Public Health, Hammersmith Hospital, Imperial College London, London, United Kingdom, Université de Lille 2, Lille, France

John Danesh

Affiliation Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom

Enrico Petretto

Affiliation Medical Research Council Clinical Sciences Centre, Faculty of Medicine, Imperial College London, London, United Kingdom

Stefan Blankenberg

Affiliation University Heart Center Hamburg, Department of General and Interventional Cardiology, Hamburg, Germany

Laurence Tiret

Affiliation INSERM UMRS 937, Pierre and Marie Curie University (UPMC, Paris 6), Paris, France

Sylvia Richardson

l.bottolo@imperial.ac.uk (LB); sylvia@mrc-bsu.cam.ac.uk (SR)

Affiliation MRC Biostatistics Unit, Institute of Public Health, Cambridge, United Kingdom

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: LB SR LT FC DT EP. Analyzed the data: LB MCH DIH BL PN LY RC MF. Contributed reagents/materials/analysis tools: MCH DIH LB. Wrote the paper: LB SR LT EP. Gutenberg Health Study (GHS) data generation: SB TZ PSW AS AZ TM. Copenhagen City Heart Study (CCHS) data generation: JD ASB WKH SFN BGN ATH. Data from an Epidemiological Study on the Insulin Resistance syndrome (DESIR) data generation: PF FF.