About the Authors

Lesca M. Holdt

Affiliations LIFE – Leipzig Research Center for Civilization Diseases, Universität Leipzig, Leipzig, Germany, Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, Leipzig, Germany, Institute of Laboratory Medicine, Ludwig-Maximilians-University Munich, Munich, Germany

Steve Hoffmann

Affiliations LIFE – Leipzig Research Center for Civilization Diseases, Universität Leipzig, Leipzig, Germany, Transcriptome Bioinformatics Group and Interdisciplinary Centre for Bioinformatics, University Leipzig, Leipzig, Germany

Kristina Sass

Affiliation Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, Leipzig, Germany

David Langenberger

Affiliations LIFE – Leipzig Research Center for Civilization Diseases, Universität Leipzig, Leipzig, Germany, Transcriptome Bioinformatics Group and Interdisciplinary Centre for Bioinformatics, University Leipzig, Leipzig, Germany

Markus Scholz

Affiliations LIFE – Leipzig Research Center for Civilization Diseases, Universität Leipzig, Leipzig, Germany, Institute for Medical Informatics, Statistics and Epidemiology, University Leipzig, Leipzig, Germany

Knut Krohn

Affiliations LIFE – Leipzig Research Center for Civilization Diseases, Universität Leipzig, Leipzig, Germany, Interdisciplinary Center for Clinical Research, University Leipzig, Leipzig, Germany

Knut Finstermeier

Affiliations LIFE – Leipzig Research Center for Civilization Diseases, Universität Leipzig, Leipzig, Germany, Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, Leipzig, Germany

Anika Stahringer

Affiliations Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, Leipzig, Germany, Institute of Laboratory Medicine, Ludwig-Maximilians-University Munich, Munich, Germany

Wolfgang Wilfert

Affiliations Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, Leipzig, Germany, Institute of Laboratory Medicine, Ludwig-Maximilians-University Munich, Munich, Germany

Frank Beutner

Affiliations LIFE – Leipzig Research Center for Civilization Diseases, Universität Leipzig, Leipzig, Germany, Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, Leipzig, Germany, Department of Internal Medicine/Cardiology, Heart Center, University Leipzig, Leipzig, Germany

Stephan Gielen

Affiliations LIFE – Leipzig Research Center for Civilization Diseases, Universität Leipzig, Leipzig, Germany, Department of Internal Medicine/Cardiology, Heart Center, University Leipzig, Leipzig, Germany

Gerhard Schuler

Affiliations LIFE – Leipzig Research Center for Civilization Diseases, Universität Leipzig, Leipzig, Germany, Department of Internal Medicine/Cardiology, Heart Center, University Leipzig, Leipzig, Germany

Gabor Gäbel

Affiliation Department of General, Thoracic, and Vascular Surgery, University Dresden, Dresden, Germany

Hendrik Bergert

Affiliation Department of General, Thoracic, and Vascular Surgery, University Dresden, Dresden, Germany

Ingo Bechmann

Affiliation Institute of Anatomy, University Leipzig, Leipzig, Germany

Peter F. Stadler

Affiliations LIFE – Leipzig Research Center for Civilization Diseases, Universität Leipzig, Leipzig, Germany, Transcriptome Bioinformatics Group and Interdisciplinary Centre for Bioinformatics, University Leipzig, Leipzig, Germany, Max Planck Institute for Mathematics in the Sciences, Leipzig, Germany, Santa Fe Institute, Santa Fe, New Mexico, United States of America

Joachim Thiery

Affiliations LIFE – Leipzig Research Center for Civilization Diseases, Universität Leipzig, Leipzig, Germany, Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, Leipzig, Germany

Daniel Teupser

daniel.teupser@med.uni-muenchen.de

Affiliations LIFE – Leipzig Research Center for Civilization Diseases, Universität Leipzig, Leipzig, Germany, Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, Leipzig, Germany, Institute of Laboratory Medicine, Ludwig-Maximilians-University Munich, Munich, Germany

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: LMH KS DT. Performed the experiments: LMH KS KK KF AS WW. Analyzed the data: LMH SH KS DL MS PFS DT. Contributed reagents/materials/analysis tools: LMH SH DL FB SG GS GG HB IB PFS JT DT. Wrote the paper: LMH DT. Critically revised and approved the final version of the manuscript: LMH SH KS DL MS KK KF AS WW FB SG GS GG HB IB PFS JT DT.