About the Authors

Stefan Nickels, Sabine Behrens, Ursula Eilber, Alina Vrieling, Anja Rudolph, Jenny Chang-Claude
Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany

Thérèse Truong, Emilie Cordina-Duverger, Florence Menegaux, Pascal Guénel
Inserm (National Institute of Health and Medical Research), CESP (Center for Research in Epidemiology and Population Health), U1018, Environmental Epidemiology of Cancer, Villejuif, France

Rebecca Hein
PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany

Kristen Stevens, Janet E. Olson, Celine M. Vachon
Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, United States of America

Katharina Buck
Department of Preventive Oncology, National Center of Tumor Diseases, Heidelberg, Germany

Martina Schmidt
Unit of Environmental Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany

Lothar Häberle, Peter A. Fasching, Matthias W. Beckmann
Department of Gynecology and Obstetrics, University Hospital, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany

Alina Vrieling
Department for Health Evidence, Radboud University Medical Centre, Nijmegen, The Netherlands

Mia Gaudet
Epidemiology Research Program, Division of Cancer Epidemiology, American Cancer Society, Atlanta, Georgia, United States of America

Jonine Figueroa, Stephen J. Chanock, Per Hall, Montserrat Garcia-Closas
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, United States of America

Nils Schoof
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden

Amanda B. Spurdle, AOCS Management Group
Queensland Institute of Medical Research, Herston, Queensland, Australia

Peter A. Fasching
Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America

John L. Hopper, Enes Makalic, Daniel F. Schmidt
Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, University of Melbourne, Melbourne, Australia

Melissa C. Southey
Department of Pathology, University of Melbourne, Melbourne, Australia

Arif B. Ekici
Institute of Human Genetics, Friedrich Alexander University Erlangen-Nuremberg, Erlangen, Germany

Olivia Fletcher
Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, United Kingdom

Lorna Gibson, Isabel dos Santos Silva, Julian Peto
London School of Hygiene and Tropical Medicine, London, United Kingdom

Manjeet K. Humphreys, Jean Wang, Doug F. Easton
Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom

Børge G. Nordestgaard, Stig E. Bojesen
Copenhagen General Population Study and Department of Clinical Biochemistry, Herlev University Hospital, University of Copenhagen, Copenhagen, Denmark

Charlotte Lanng
Department of Breast Surgery, Herlev University Hospital, University of Copenhagen, Copenhagen, Denmark

Hoda Anton-Culver, Argyrios Ziogas
Department of Epidemiology, University of California Irvine, Irvine, California, United States of America

Leslie Bernstein
Beckman Research Institute of the City of Hope, Duarte, California, United States of America

Christina A. Clarke, Esther M. John
Cancer Prevention Institute of California, Fremont, California, United States of America

Christina A. Clarke, Esther M. John
Division of Epidemiology, Department of Health Research and Policy, Stanford University School of Medicine, Stanford, California, United States of America

Hermann Brenner, Heiko Müller, Volker Arndt
Division of Clinical Epidemiology and Ageing Research, German Cancer Research Center (DKFZ), Heidelberg, Germany

Christa Stegmaier
Saarland Cancer Registry, Saarbrücken, Germany

Hiltrud Brauch, The GENICA Network
Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany

Hiltrud Brauch, The GENICA Network
University of Tübingen, Tübingen, Germany

Thomas Brüning, The GENICA Network
Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr-Universität Bochum (IPA), Bochum, Germany

Volker Harth, The GENICA Network
Institute and Outpatient Clinic of Occupational Medicine, Saarland University Medical Center and Saarland University Faculty of Medicine, Homburg, Germany

Volker Harth
Institute for Occupational Medicine and Maritime Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

The GENICA Network
Department of Internal Medicine, Evangelische Kliniken Bonn gGmbH, Johanniter Krankenhaus, Bonn, Germany

The GENICA Network
Institute of Pathology, University of Bonn, Bonn, Germany

The GENICA Network
Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany

Arto Mannermaa, Veli-Matti Kosma, Jaana M. Hartikainen
School of Medicine, Institute of Clinical Medicine, Department of Pathology and Forensic Medicine, University of Eastern Finland, Kuopio, Finland

Arto Mannermaa, Vesa Kataja, Veli-Matti Kosma, Jaana M. Hartikainen
Biocenter Kuopio, Cancer Center of Eastern Finland, University of Eastern Finland, Kuopio, Finland

Vesa Kataja
School of Medicine, Institute of Clinical Medicine, Department of Oncology, University of Eastern Finland, Kuopio, Finland

kConFab, AOCS Management Group
The Kathleen Cuningham Foundation for Resesarch into Familial Breast Cancer (kConFab), Peter MacCallum Cancer Centre, East Melbourne, Australia

Diether Lambrechts, Dominiek Smeets
Vesalius Research Center (VRC), VIB, Leuven, Belgium

Patrick Neven, Robert Paridaens
Multidisciplinary Breast Center, University Hospital Gasthuisberg, Leuven, Belgium

Dieter Flesch-Janys, Nadia Obi
Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, University Clinic Hamburg-Eppendorf, Hamburg, Germany

Shan Wang-Gohrke
Department of Obstetrics and Gynecology, University of Ulm, Ulm, Germany

Fergus J. Couch
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, United States of America

Graham G. Giles, Gianluca Severi, Laura Baglietto
Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne, Australia

Graham G. Giles, Gianluca Severi, Laura Baglietto
Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, University of Melbourne, Australia

Kenneth Offit
Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America

Alexander Miron
Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America

Irene L. Andrulis
Ontario Cancer Genetics Network, Fred A. Litwin Center for Cancer Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada

Irene L. Andrulis
Department of Molecular Genetics, University of Toronto, Toronto, Canada

Julia A. Knight
Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada

Julia A. Knight
Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, Canada

Gord Glendon
Ontario Cancer Genetics Network, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada

Anna Marie Mulligan
Laboratory Medicine Program, University Health Network, Toronto, Canada

Anna Marie Mulligan
Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada

Jolanta Lissowska
Department of Cancer Epidemiology and Prevention, M. Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland

Jianjun Liu
Human Genetics, Genome Institute of Singapore, Singapore, Singapore

Angela Cox, Helen Cramp, Dan Connley
Institute for Cancer Studies, Department of Oncology, University of Sheffield, Sheffield, United Kingdom

Sabapathy Balasubramanian
Academic Unit of Surgical Oncology, Department of Oncology, University of Sheffield, Sheffield, United Kingdom

Alison M. Dunning, Mitul Shah
Department of Oncology, University of Cambridge, Cambridge, United Kingdom

Amy Trentham-Dietz, Polly Newcomb
University of Wisconsin Carbone Cancer Center, Madison, Wisconsin, United States of America

Polly Newcomb
Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

Linda Titus
Department of Community and Family Medicine, Department of Pediatrics, Dartmouth Medical School, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, United States of America

Kathleen Egan
Division of Population Sciences, Moffitt Cancer Center and Research Institute, Tampa, Florida, United States of America

Elizabeth K. Cahoon, Preetha Rajaraman, Alice J. Sigurdson, Michele M. Doody
Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, United States of America

Paul D. P. Pharoah
Department of Oncology and Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom

Marjanka K. Schmidt
Division of Molecular Pathology and Division of Psychosocial Research and Epidemiology, Netherlands Cancer Institute, Amsterdam, The Netherlands

Montserrat Garcia-Closas
Sections of Epidemiology and Genetics, Institute of Cancer Research and Breakthrough Breast Cancer Research Centre, London, United Kingdom

Roger L. Milne
Genetic and Molecular Epidemiology Group, Human Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain

Corresponding Author

j.chang-claude@dkfz.de

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: P Guénel, PDP Pharoah, MK Schmidt, P Hall, DF Easton, M Garcia-Closas, RL Milne, J Chang-Claude. Performed the experiments: AM Dunning. Analyzed the data: S Nickels, T Truong, R Hein, K Stevens, K Buck, S Behrens, U Eilber, M Schmidt, L Häberle, A Vrieling, M Gaudet, J Figueroa, N Schoof, AB Spurdle, A Rudolph, PA Fasching, J Chang-Claude. Contributed reagents/materials/analysis tools: JL Hopper, E Makalic, DF Schmidt, MC Southey, MW Beckman, AB Ekici, O Fletcher, L Gibson, I dos Santo Silva, J Peto, MK Humphreys, J Wang, E Cordina-Duverger, F Menegaux, BG Nordestgaard, SE Bojeson, C Lanng, H Anton-Culver, A Ziogas, L Bernstein, CA Clarke, H Brenner, H Müller, V Arndt, C Stegmaier, H Brauch, T Brüning, V Harth, A Mannermaa, V Kataj, V-M Kosma, JM Hartikainen, D Lambrechts, D Smeets, P Neven, R Paridaens, D Flesch-Janys, N Obi, S Wang-Gohrke, FJ Couch, JE Olson, CM Vachon, GG Giles, G Severi, L Baglietto, K Offit, EM John, A Miron, IL Andrulis, JA Knight, G Glendon, AM Mulligan, SJ Chanock, J Lissowska, J Liu, A Cox, H Cramp, D Connley, S Balasubramanian, AM Dunning, M Shah, A Trentham-Dietz, P Newcomb, L Titus, K Egan, EK Cahoon, P Rajaraman, AJ Sigurdson, MM Doody, P Guénel, PDP Pharoah, MK Schmidt, P Hall, DF Easton, M Garcia-Closas, RL Milne, J Chang-Claude. Wrote the paper: S Nickels, T Truong, P Hall, DF Easton, M Garcia-Closas, RL Milne, J Chang-Claude.