About the Authors

Jessica L. Petersen, James R. Mickelson, Stephanie J. Valberg, Molly E. McCue
College of Veterinary Medicine, University of Minnesota, St. Paul, Minnesota, United States of America

Aaron K. Rendahl
School of Statistics, University of Minnesota, Minneapolis, Minnesota, United States of America

Lisa S. Andersson, Jeanette Axelsson, Gabriella Lindgren, Sofia Mikko
Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Uppsala, Sweden

Ernie Bailey, Kathryn T. Graves
Department of Veterinary Science, University of Kentucky, Lexington, Kentucky, United States of America

Danika Bannasch, M. Cecilia T. Penedo
School of Veterinary Medicine, University of California Davis, Davis, California, United States of America

Matthew M. Binns
Equine Analysis, Midway, Kentucky, United States of America

Alexandre S. Borges
Department of Veterinary Clinical Science, University Estadual Paulista, Botucatu, Brazil

Pieter Brama
School of Veterinary Medicine, University College Dublin, Dublin, Ireland

Artur da Câmara Machado, Maria Susana Lopes
Department of Agriculture, University of the Azores, Angra do Heroísmo, Portugal

Stefano Capomaccio, Katia Cappelli
Faculty of Veterinary Medicine, University of Perugia, Perugia, Italy

E. Gus Cothran
College of Veterinary Medicine and Biomedical Science, Texas A&M University, College Station, Texas, United States of America

Ottmar Distl
Institute for Animal Breeding and Genetics, University of Veterinary Medicine Hannover, Hannover, Germany

Laura Fox-Clipsham, June Swinburne, Mark Vaudin
Animal Health Trust, Lanwades Park, Newmarket, Suffolk, United Kingdom

Gérard Guérin
Animal Genetics and Integrative Biology Unit, French National Institute for Agricultural Research, Jouy en Josas, France

Bianca Haase, Claire M. Wade
Faculty of Veterinary Science, University of Sydney, New South Wales, Australia

Telhisa Hasegawa
Nihon Bioresource College, Koga, Ibaraki, Japan

Karin Hemmann, Hannes Lohi, Marja Raekallio
Faculty of Veterinary Medicine, University of Helsinki, Helsinki, Finland

Emmeline W. Hill, Beatrice A. McGivney
College of Agriculture, Food Science and Veterinary Medicine, University College Dublin, Dublin, Ireland

Tosso Leeb
Institute of Genetics, University of Bern, Bern, Switzerland

Nicholas Orr
Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, United Kingdom

Richard J. Piercy
Comparative Neuromuscular Diseases Laboratory, Royal Veterinary College, London, United Kingdom

Stefan Rieder
Swiss National Stud Farm SNSTF, Agroscope Liebefeld-Posieux Research Station, Avenches, Switzerland

Knut H. Røed
Department of Basic Sciences and Aquatic Medicine, Norwegian School of Veterinary Science, Oslo, Norway

June Swinburne
Animal DNA Diagnostics, Cambridge, United Kingdom

Teruaki Tozaki
Department of Molecular Genetics, Laboratory of Racing Chemistry, Utsunomiya, Tochigi, Japan

Corresponding Author

jlpeters@umn.edu

Competing Interests

Equinome Ltd. (EWH, Director) has been granted a license for commercial use of MSTN data as contained within patent applications: U.S. Provisional Serial Number 61/136553; Irish Patent Application Numbers 2008/0735 and 2010/0151; and Patent Cooperation Treaty number PCT/IE2009/000062. The PCT publication WO2010/029527A published 18 March 2010. Title: “A method for predicting athletics performance potential” and U.S. publication US2011/0262915 published 27 October 2011. Title: “Method for predicting the athletic performance potential of a subject.” EWH, NO, and BAM are named on the applications. MMB works for The Genetic Edge, previously published a paper on the association between SNPs in the MSTN region and best racing distance for elite Thoroughbred horses [46], and uses these markers in commercial tests. LSA and GL are co-applicants on a patent application concerning the commercial utilization of the DMRT3 mutation. These commercial ventures had no influence on the interpretation of the results relating to myostatin or gait presented in the paper.

Author Contributions

Conceived and designed the experiments: JLP JRM SJV MEM. Performed the experiments: JLP AKR SJV MEM. Analyzed the data: JLP AKR MEM. Contributed reagents/materials/analysis tools: JLP JRM AKR SJV LSA JA EB DB MMB ASB PB AdCM SC KC EGC OD LF-C KTG GG BH TH KH EWH TL GL HL MSL BAM SM NO MCTP RJP MR SR KHR JS TT MV CMW MEM. Wrote the paper: JLP JRM MEM.