About the Authors

Fiona McMurray

Contributed equally to this work with: Fiona McMurray, Chris D. Church, Rachel Larder, George Nicholson

Affiliation MRC Harwell, Harwell Science and Innovation Campus, Harwell, United Kingdom

Chris D. Church

Contributed equally to this work with: Fiona McMurray, Chris D. Church, Rachel Larder, George Nicholson

Affiliation MRC Harwell, Harwell Science and Innovation Campus, Harwell, United Kingdom

Rachel Larder

Contributed equally to this work with: Fiona McMurray, Chris D. Church, Rachel Larder, George Nicholson

Affiliation University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, United Kingdom

George Nicholson

Contributed equally to this work with: Fiona McMurray, Chris D. Church, Rachel Larder, George Nicholson

Affiliations MRC Harwell, Harwell Science and Innovation Campus, Harwell, United Kingdom, Department of Statistics, University of Oxford, Oxford, United Kingdom

Sara Wells

Affiliation MRC Harwell, Harwell Science and Innovation Campus, Harwell, United Kingdom

Lydia Teboul

Affiliation MRC Harwell, Harwell Science and Innovation Campus, Harwell, United Kingdom

Y. C. Loraine Tung

Affiliation University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, United Kingdom

Debra Rimmington

Affiliation University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, United Kingdom

Fatima Bosch

Affiliations Center of Animal Biotechnology and Gene Therapy and Department of Biochemistry and Molecular Biology, School of Veterinary Medicine, Universitat Autònoma de Barcelona, Bellaterra, Spain, Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Barcelona, Spain

Veronica Jimenez

Affiliations Center of Animal Biotechnology and Gene Therapy and Department of Biochemistry and Molecular Biology, School of Veterinary Medicine, Universitat Autònoma de Barcelona, Bellaterra, Spain, Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Barcelona, Spain

Giles S. H. Yeo

Affiliation University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, United Kingdom

Stephen O'Rahilly

Affiliation University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, United Kingdom

Frances M. Ashcroft

These authors also contributed equally to this work.

Affiliation Henry Wellcome Centre for Gene Function, Department of Physiology, Anatomy, and Genetics, University of Oxford, Oxford, United Kingdom

Anthony P. Coll

These authors also contributed equally to this work.

Affiliation University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, United Kingdom

Roger D. Cox

r.cox@har.mrc.ac.uk

These authors also contributed equally to this work.

Affiliation MRC Harwell, Harwell Science and Innovation Campus, Harwell, United Kingdom

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: FM CDC FMA APC RDC GSHY SO. Performed the experiments: FM CDC SW LT RL YCLT DR APC. Analyzed the data: FM CDC RL GN APC FMA RDC. Contributed reagents/materials/analysis tools: FB VJ GSHY. Wrote the paper: FM CDC FMA APC RDC.