About the Authors

Sarah A. Pendergrass

Affiliation Center for Systems Genomics, Department of Biochemistry and Molecular Biology, The Pennsylvania State University, Eberly College of Science, The Huck Institutes of the Life Sciences, University Park, Pennsylvania, United States of America

Kristin Brown-Gentry

Affiliation Center for Human Genetics Research, Vanderbilt University, Nashville, Tennessee, United States of America

Scott Dudek

Affiliation Center for Human Genetics Research, Vanderbilt University, Nashville, Tennessee, United States of America

Alex Frase

Affiliation Center for Systems Genomics, Department of Biochemistry and Molecular Biology, The Pennsylvania State University, Eberly College of Science, The Huck Institutes of the Life Sciences, University Park, Pennsylvania, United States of America

Eric S. Torstenson

Affiliation Center for Human Genetics Research, Vanderbilt University, Nashville, Tennessee, United States of America

Robert Goodloe

Affiliation Center for Human Genetics Research, Vanderbilt University, Nashville, Tennessee, United States of America

Jose Luis Ambite

Affiliation Information Sciences Institute, University of Southern California, Marina del Rey, California, United States of America

Christy L. Avery

Affiliation Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina, United States of America

Steve Buyske

Affiliations Department of Genetics, Rutgers University, Piscataway, New Jersey, United States of America, Department of Statistics, Rutgers University, Piscataway, New Jersey, United States of America

Petra Bůžková

Affiliation Department of Biostatistics, University of Washington, Seattle, Washington, United States of America

Ewa Deelman

Affiliation Information Sciences Institute, University of Southern California, Marina del Rey, California, United States of America

Megan D. Fesinmeyer

Affiliation Division of Public Health, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

Christopher A. Haiman

Affiliation Department of Preventive Medicine, Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles, California, United States of America

Gerardo Heiss

Affiliation Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina, United States of America

Lucia A. Hindorff

Affiliation National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America

Chu-Nan Hsu

Affiliation Information Sciences Institute, University of Southern California, Marina del Rey, California, United States of America

Rebecca D. Jackson

Affiliation Ohio State University, Columbus, Ohio, United States of America

Charles Kooperberg

Affiliation Division of Public Health, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

Loic Le Marchand

Affiliation Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii, United States of America

Yi Lin

Affiliation Division of Public Health, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

Tara C. Matise

Affiliation Department of Genetics, Rutgers University, Piscataway, New Jersey, United States of America

Kristine R. Monroe

Affiliation Department of Preventive Medicine, Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles, California, United States of America

Larry Moreland

Affiliation University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

Sungshim L. Park

Affiliation Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii, United States of America

Alex Reiner

Affiliations Division of Public Health, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America, Department of Epidemiology, University of Washington, Seattle, Washington, United States of America

Robert Wallace

Affiliation Departments of Epidemiology and Internal Medicine, University of Iowa, Iowa City, Iowa, United States of America

Lynn R. Wilkens

Affiliation Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii, United States of America

Dana C. Crawford

Affiliations Center for Human Genetics Research, Vanderbilt University, Nashville, Tennessee, United States of America, Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, United States of America

Marylyn D. Ritchie

marylyn.ritchie@psu.edu

Affiliation Center for Systems Genomics, Department of Biochemistry and Molecular Biology, The Pennsylvania State University, Eberly College of Science, The Huck Institutes of the Life Sciences, University Park, Pennsylvania, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SAP CK SB DCC MDR JLA CLA ED MDF CAH LAH C-NH RDJ LLM TCM KRM LM AR. Performed the experiments: SAP KB-G SD AF EST RG SB YL SLP. Analyzed the data: SAP KB-G SD AF EST RG SB YL SLP RW. Contributed reagents/materials/analysis tools: SAP SD AF EST RG SB GH CK LRW YL PB SLP. Wrote the paper: SAP JLA CLA SB PB ED MDF CAH GH LAH C-NH RDJ CK LLM YL SLP TCM KRM LM AR RW LRW DCC MDR. Developed the software for the plots in this publication: SAP SD.