About the Authors

Stefano Lise

Contributed equally to this work with: Stefano Lise, Yvonne Clarkson, Emma Perkins

Affiliations Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom, NIHR Biomedical Research Centre Oxford, Oxford, United Kingdom

Yvonne Clarkson

Contributed equally to this work with: Stefano Lise, Yvonne Clarkson, Emma Perkins

Affiliation Centre for Integrative Physiology, Euan MacDonald Centre for Motor Neurone Disease Research, University of Edinburgh, Edinburgh, United Kingdom

Emma Perkins

Contributed equally to this work with: Stefano Lise, Yvonne Clarkson, Emma Perkins

Affiliation Centre for Integrative Physiology, Euan MacDonald Centre for Motor Neurone Disease Research, University of Edinburgh, Edinburgh, United Kingdom

Alexandra Kwasniewska

Affiliations Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom

Elham Sadighi Akha

Affiliations Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom, NIHR Biomedical Research Centre Oxford, Oxford, United Kingdom

Ricardo Parolin Schnekenberg

Affiliations Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom, School of Medicine, Universidade Positivo, Curitiba, Brazil

Daumante Suminaite

Affiliation Centre for Integrative Physiology, Euan MacDonald Centre for Motor Neurone Disease Research, University of Edinburgh, Edinburgh, United Kingdom

Jilly Hope

Affiliation Centre for Integrative Physiology, Euan MacDonald Centre for Motor Neurone Disease Research, University of Edinburgh, Edinburgh, United Kingdom

Ian Baker

Affiliation Russell Cairns Unit, Oxford University Hospitals NHS Trust, Oxford, United Kingdom

Lorna Gregory

Affiliation Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

Angie Green

Affiliation Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

Chris Allan

Affiliation Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

Sarah Lamble

Affiliation Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

Sandeep Jayawant

Affiliation Department of Paediatrics, Oxford University Hospitals NHS Trust, Oxford, United Kingdom

Gerardine Quaghebeur

Affiliation Department of Neuroradiology, Oxford University Hospitals NHS Trust, Oxford, United Kingdom

M. Zameel Cader

Affiliation Department of Anatomy, Physiology, and Genetics, University of Oxford, Oxford, United Kingdom

Sarah Hughes

Affiliation Royal Berkshire Foundation Trust Hospital, Reading, United Kingdom

Richard J. E. Armstrong

Affiliations Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom, Royal Berkshire Foundation Trust Hospital, Reading, United Kingdom

Alexander Kanapin

Affiliation Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

Andrew Rimmer

Affiliation Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

Gerton Lunter

Affiliation Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

Iain Mathieson

Affiliation Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

Jean-Baptiste Cazier

Affiliation Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

David Buck

Affiliation Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

Jenny C. Taylor

Affiliations Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom, NIHR Biomedical Research Centre Oxford, Oxford, United Kingdom

David Bentley

Affiliation Illumina Cambridge, Saffron Walden, United Kingdom

Gilean McVean

Affiliation Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

Peter Donnelly

Affiliation Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

Samantha J. L. Knight

Affiliations Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom, NIHR Biomedical Research Centre Oxford, Oxford, United Kingdom

Mandy Jackson

mandy.jackson@staffmail.ed.ac.uk (M Jackson); andrea.nemeth@eye.ox.ac.uk (AH Németh)

Affiliation Centre for Integrative Physiology, Euan MacDonald Centre for Motor Neurone Disease Research, University of Edinburgh, Edinburgh, United Kingdom

Jiannis Ragoussis

Affiliation Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

Andrea H. Németh

mandy.jackson@staffmail.ed.ac.uk (M Jackson); andrea.nemeth@eye.ox.ac.uk (AH Németh)

Affiliations Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom, NIHR Biomedical Research Centre Oxford, Oxford, United Kingdom, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom, Department of Clinical Genetics, Oxford University Hospitals NHS Trust, Oxford, United Kingdom

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: AH Németh, J Ragoussis, M Jackson, SJL Knight. Performed the experiments: Y Clarkson, E Perkins, A Kwasniewska, SJL Knight, E Sadighi Akha, R Parolin Schnekenberg, D Suminaite, J Hope, I Baker, L Gregory, A Green, C Allan, S Lamble. Analyzed the data: AH Németh. S Lise, M Jackson, Y Clarkson, E Perkins, A Kwasniewska, R Parolin Schnekenberg, J Ragoussis, E Sadighi Akha, SJL Knight, D Suminaite, J Hope, A Kanapin, J-B Cazier. Wrote the paper: AH Németh, S Lise, M Jackson, J Ragoussis. Critical review of manuscript: S Lise, Y Clarkson, E Perkins, A Kwasniewska, E Sadighi Akha, R Parolin Schnekenberg, D Suminaite, J Hope, I Baker, L Gregory, A Green, C Allan, S Lamble, S Jayawant, G Quaghebeur, MZ Cader, S Hughes, RJE Armstrong, A Kanapin, A Rimmer, G Lunter, I Mathieson, J-B Cazier, D Buck, JC Taylor, D Bentley, G McVean, P Donnelly, SJL Knight, M Jackson, J Ragoussis, AH Németh. Clinical review and obtaining data on patients: AH Németh, S Jayawant, G Quaghebeur, MZ Cader, S Hughes, A Rimmer, I Baker. Reviewed neuroimaging: G Quaghebeur. Designed the software used in analysis: A Rimmer, I Mathieson, G Lunter, G McVean. Set up WGS500 project: P Donnelly, D Bentley, G McVean, JC Taylor.