About the Authors

Ke Hao

Contributed equally to this work with: Ke Hao, Yohan Bossé, David C. Nickle

Affiliations Merck Research Laboratories, Boston, Massachusetts, United States of America, Merck, Rahway, New Jersey, United States of America, Genetics, Rosetta Inpharmatics, Merck, Seattle, Washington, United States of America

Yohan Bossé

Contributed equally to this work with: Ke Hao, Yohan Bossé, David C. Nickle

Affiliations Department of Molecular Medicine, Laval University, Québec City, Canada, Institut Universitaire de Cardiologie et de Pneumologie de Québec, Laval University, Québec City, Canada

David C. Nickle

Contributed equally to this work with: Ke Hao, Yohan Bossé, David C. Nickle

david_nickle@merck.com

Affiliations Merck Research Laboratories, Boston, Massachusetts, United States of America, Merck, Rahway, New Jersey, United States of America, Genetics, Rosetta Inpharmatics, Merck, Seattle, Washington, United States of America

Peter D. Paré

Affiliations The University of British Columbia James Hogg Research Laboratory, St Paul's Hospital, Vancouver, Canada, Respiratory Division, Department of Medicine, University of British Columbia, Vancouver, Canada

Dirkje S. Postma

Affiliation Department of Pulmonology, University Medical Center Groningen, GRIAC Research Institute, University of Groningen, Groningen, The Netherlands

Michel Laviolette

Affiliation Institut Universitaire de Cardiologie et de Pneumologie de Québec, Laval University, Québec City, Canada

Andrew Sandford

Affiliations The University of British Columbia James Hogg Research Laboratory, St Paul's Hospital, Vancouver, Canada, Respiratory Division, Department of Medicine, University of British Columbia, Vancouver, Canada

Tillie L. Hackett

Affiliation The University of British Columbia James Hogg Research Laboratory, St Paul's Hospital, Vancouver, Canada

Denise Daley

Affiliations The University of British Columbia James Hogg Research Laboratory, St Paul's Hospital, Vancouver, Canada, Respiratory Division, Department of Medicine, University of British Columbia, Vancouver, Canada

James C. Hogg

Affiliations The University of British Columbia James Hogg Research Laboratory, St Paul's Hospital, Vancouver, Canada, Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada

W. Mark Elliott

Affiliation The University of British Columbia James Hogg Research Laboratory, St Paul's Hospital, Vancouver, Canada

Christian Couture

Affiliation Institut Universitaire de Cardiologie et de Pneumologie de Québec, Laval University, Québec City, Canada

Maxime Lamontagne

Affiliation Institut Universitaire de Cardiologie et de Pneumologie de Québec, Laval University, Québec City, Canada

Corry-Anke Brandsma

Affiliation Department of Pathology and Medical Biology, University Medical Center Groningen, GRIAC Research Institute, University of Groningen, Groningen, The Netherlands

Maarten van den Berge

Affiliation Department of Pulmonology, University Medical Center Groningen, GRIAC Research Institute, University of Groningen, Groningen, The Netherlands

Gerard Koppelman

Affiliation Department of Pediatric Pulmonology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

Alise S. Reicin

Affiliation Merck, Rahway, New Jersey, United States of America

Donald W. Nicholson

Affiliation Merck, Rahway, New Jersey, United States of America

Vladislav Malkov

Affiliation Merck, Rahway, New Jersey, United States of America

Jonathan M. Derry

Affiliation Sage Bionetworks, Seattle, Washington, United States of America

Christine Suver

Affiliation Sage Bionetworks, Seattle, Washington, United States of America

Jeffrey A. Tsou

Affiliation Merck, Rahway, New Jersey, United States of America

Amit Kulkarni

Affiliation Merck, Rahway, New Jersey, United States of America

Chunsheng Zhang

Affiliation Merck, Rahway, New Jersey, United States of America

Rupert Vessey

Affiliation Merck, Rahway, New Jersey, United States of America

Greg J. Opiteck

Affiliation Merck, Rahway, New Jersey, United States of America

Sean P. Curtis

Affiliation Merck, Rahway, New Jersey, United States of America

Wim Timens

These authors also contributed equally to this work.

Affiliation Department of Pathology and Medical Biology, University Medical Center Groningen, GRIAC Research Institute, University of Groningen, Groningen, The Netherlands

Don D. Sin

These authors also contributed equally to this work.

Affiliations The University of British Columbia James Hogg Research Laboratory, St Paul's Hospital, Vancouver, Canada, Respiratory Division, Department of Medicine, University of British Columbia, Vancouver, Canada

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: K Hao, Y Bossé, DC Nickle, PD Paré, DS Postma, M Laviolette, JC Hogg, JM Derry, GJ Opiteck, SP Curtis, W Timens, DD Sin. Performed the experiments: K Hao, DC Nickle, TL Hackett, JA Tsou. Analyzed the data: K Hao, Y Bossé, DC Nickle, D Daley, M Lamontagne, V Malkov, A Kulkarni, C Zhang. Contributed reagents/materials/analysis tools: PD Paré, DS Postma, M Laviolette, JC Hogg, WM Elliot, C Couture, C-A Brandsma, M van den Berge, W Timens, DD Sin. Wrote the paper: K Hao, Y Bossé, DC Nickle. Oversaw project conception: K Hao, Y Bossé, DC Nickle, PD Paré, DS Postma, M Laviolette, JC Hogg, AS Reicin, DW Nicholson, JM Derry, R Vessey, GJ Opiteck, SP Curtis, W Timens, DD Sin. Performed statistical analysis: K Hao, Y Bossé, DC Nickle, D Daley, M Lamontagne, V Malkov, A Kulkarni, C Zhang. Edited the manuscript for intellectual content: PD Paré, DS Postma, M Laviolette, A Sandford, D Daley, JC Hogg, AS Reicin, DW Nicholson, R Vessey, GJ Opiteck, SP Curtis, W Timens, DD Sin. Coordinated the study: K Hao, Y Bossé, DC Nickle, PD Paré, DS Postma, M Laviolette, GJ Opiteck, W Timens, DD Sin, TL Hackett, G Koppelman, C Suver, JA Tsou.