About the Authors

Benjamin F. Voight

Contributed equally to this work with: Benjamin F. Voight, Hyun Min Kang

Affiliations Medical Population Genetics, The Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Department of Pharmacology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America

Hyun Min Kang

Contributed equally to this work with: Benjamin F. Voight, Hyun Min Kang

Affiliation Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, United States of America

Jun Ding

Affiliation Laboratory of Genetics, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America

Cameron D. Palmer

Affiliations Medical Population Genetics, The Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Divisions of Endocrinology and Genetics and Program in Genomics, Children's Hospital, Boston, Massachusetts, United States of America

Carlo Sidore

Affiliations Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, United States of America, Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Monserrato, Italy, Dipartimento di Scienze Biomediche, Università di Sassari, Sassari, Italy

Peter S. Chines

Affiliation Genome Technology Branch, National Human Genome Research Institute, Bethesda, Maryland, United States of America

Noël P. Burtt

Affiliation Medical Population Genetics, The Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

Christian Fuchsberger

Affiliation Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, United States of America

Yanming Li

Affiliation Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, United States of America

Jeanette Erdmann

Affiliation Universität zu Lübeck, Medizinische Klinik II, and Nordic Center of Cardiovascular Research, Lübeck, Germany

Timothy M. Frayling

Affiliation Genetics of Complex Traits, Peninsula College of Medicine and Dentistry, University of Exeter, Exeter, United Kingdom

Iris M. Heid

Affiliations Department of Epidemiology and Preventive Medicine, University Hospital Regensburg, Regensburg, Germany, Helmholtz Zentrum München—German Research Center for Environmental Health, Institute of Epidemiology, Neuherberg, Germany

Anne U. Jackson

Affiliation Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, United States of America

Toby Johnson

Affiliation Clinical Pharmacology and Barts and the London Genome Centre, William Harvey Research Institute, Barts and the London School of Medicine, Queen Mary University of London, London, United Kingdom

Tuomas O. Kilpeläinen

Affiliation MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, United Kingdom

Cecilia M. Lindgren

Affiliation Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

Andrew P. Morris

Affiliation Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

Inga Prokopenko

Affiliations Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom, Oxford Centre for Diabetes, Endocrinology, and Metabolism, Churchill Hospital, University of Oxford, Oxford, United Kingdom

Joshua C. Randall

Affiliation Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

Richa Saxena

Affiliations Medical Population Genetics, The Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, Massachusetts, United States of America

Nicole Soranzo

Affiliation Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom

Elizabeth K. Speliotes

Affiliations Medical Population Genetics, The Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Department of Internal Medicine, Division of Gastroenterology and Center for Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan, United States of America

Tanya M. Teslovich

Affiliation Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, United States of America

Eleanor Wheeler

Affiliation Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom

Jared Maguire

Affiliation Medical Population Genetics, The Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

Melissa Parkin

Affiliation Medical Population Genetics, The Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

Simon Potter

Affiliation Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom

N. William Rayner

Affiliations Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom, Oxford Centre for Diabetes, Endocrinology, and Metabolism, Churchill Hospital, University of Oxford, Oxford, United Kingdom, Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom

Neil Robertson

Affiliations Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom, Oxford Centre for Diabetes, Endocrinology, and Metabolism, Churchill Hospital, University of Oxford, Oxford, United Kingdom

Kathleen Stirrups

Affiliation Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom

Wendy Winckler

Affiliation Medical Population Genetics, The Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

Serena Sanna

Affiliation Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Monserrato, Italy

Antonella Mulas

Affiliation Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Monserrato, Italy

Ramaiah Nagaraja

Affiliation Laboratory of Genetics, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America

Francesco Cucca

Affiliations Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Monserrato, Italy, Dipartimento di Scienze Biomediche, Università di Sassari, Sassari, Italy

Inês Barroso

Affiliations Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom, University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, United Kingdom

Panos Deloukas

Affiliation Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom

Ruth J. F. Loos

Affiliation MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, United Kingdom

Sekar Kathiresan

Affiliations Medical Population Genetics, The Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Cardiovascular Research Center and Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America

Patricia B. Munroe

Affiliation Clinical Pharmacology and Barts and the London Genome Centre, William Harvey Research Institute, Barts and the London School of Medicine, Queen Mary University of London, London, United Kingdom

Christopher Newton-Cheh

Affiliations Medical Population Genetics, The Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Cardiovascular Research Center and Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America

Arne Pfeufer

Affiliations Institute of Human Genetics, Klinikum Rechts der Isar Technische Universität München, Munich, Germany, Institute of Human Genetics, Helmholtz Zentrum München, Deutsches Forschungszentrum für Gesundheit und Umwelt, Neuherberg, Germany, EURAC Center of Biomedicine, Bolzano, Italy

Nilesh J. Samani

Affiliations Department of Cardiovascular Sciences, Glenfield Hospital, University of Leicester, Leicester, United Kingdom, Leicester NIHR Biomedical Research Unit in Coronary Artery Disease, Glenfield Hospital, Leicester, United Kingdom

Heribert Schunkert

Affiliation Universität zu Lübeck, Medizinische Klinik II, and Nordic Center of Cardiovascular Research, Lübeck, Germany

Joel N. Hirschhorn

Affiliations Medical Population Genetics, The Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Divisions of Endocrinology and Genetics and Program in Genomics, Children's Hospital, Boston, Massachusetts, United States of America, Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America

David Altshuler

altshuler@molbio.mgh.harvard.edu (DA); mark.mccarthy@drl.ox.ac.uk (MIM); goncalo@umich.edu (GRA); boehnke@umich.edu (MB)

Affiliations Medical Population Genetics, The Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Molecular Biology, Harvard Medical School, Boston, Massachusetts, United States of America, Diabetes Unit, Massachusetts General Hospital, Boston, Massachusetts, United States of America

Mark I. McCarthy

altshuler@molbio.mgh.harvard.edu (DA); mark.mccarthy@drl.ox.ac.uk (MIM); goncalo@umich.edu (GRA); boehnke@umich.edu (MB)

Affiliations Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom, Oxford Centre for Diabetes, Endocrinology, and Metabolism, Churchill Hospital, University of Oxford, Oxford, United Kingdom, Oxford NIHR Biomedical Research Centre, Churchill Hospital, Oxford, United Kingdom

Gonçalo R. Abecasis

altshuler@molbio.mgh.harvard.edu (DA); mark.mccarthy@drl.ox.ac.uk (MIM); goncalo@umich.edu (GRA); boehnke@umich.edu (MB)

Affiliation Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, United States of America

Michael Boehnke

altshuler@molbio.mgh.harvard.edu (DA); mark.mccarthy@drl.ox.ac.uk (MIM); goncalo@umich.edu (GRA); boehnke@umich.edu (MB)

Affiliation Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: BFV HMK JNH DA MIM GRA MB. Analyzed the data: BFV HMK JD CDP CS PSC NPB CF YL JE TMF IMH AUJ TJ TOK CML APM IP JCR RS NS EKS TMT EW JM MP SP NWR NR KS WW SS AM. Contributed reagents/materials/analysis tools: AM RN FC IB PD RJFL SK PBM CN-C AP NJS HS. Wrote the paper: BFV HMK GRA MB. Critically revised the manuscript, including comments and feedback: BFV HMK JE TMF TOK CML NS NWR SS RN IB RJFL SK CN-C NJS JNH DA MIM GRA MB.