About the Authors

Courtney A. Lovejoy

Affiliation Laboratory for Cell Biology and Genetics, The Rockefeller University, New York, New York, United States of America

Wendi Li

Affiliation Laboratory for Cell Biology and Genetics, The Rockefeller University, New York, New York, United States of America

Steven Reisenweber

Affiliation Laboratory for Cell Biology and Genetics, The Rockefeller University, New York, New York, United States of America

Supawat Thongthip

Affiliation Laboratory for Cell Biology and Genetics, The Rockefeller University, New York, New York, United States of America

Joanne Bruno

Affiliation Laboratory for Cell Biology and Genetics, The Rockefeller University, New York, New York, United States of America

Titia de Lange

delange@mail.rockefeller.edu

Affiliation Laboratory for Cell Biology and Genetics, The Rockefeller University, New York, New York, United States of America

Saurav De

Affiliation Molecular Biology Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America

John H. J. Petrini

Affiliation Molecular Biology Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America

Patricia A. Sung

Affiliation Developmental Biology Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America

Maria Jasin

Affiliation Developmental Biology Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America

Joseph Rosenbluh

Affiliation Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America

Yaara Zwang

Affiliations Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America

Barbara A. Weir

Affiliation Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America

Charlie Hatton

Affiliation Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America

Elena Ivanova

Affiliation Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America

Laura Macconaill

Affiliation Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America

Megan Hanna

Affiliation Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America

William C. Hahn

Affiliations Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America

Neal F. Lue

Affiliation Department of Microbiology and Immunology, W. R. Hearst Microbiology Research Center, Weill Medical College, Cornell University, New York, New York, United States of America

Roger R. Reddel

Affiliations Children's Medical Research Institute, Westmead, New South Wales, Australia, Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia

Yuchen Jiao

Affiliation Ludwig Center for Cancer Genetics and Therapeutics, Johns Hopkins Sidney Kimmel Cancer Center, Baltimore, Maryland, United States of America

Kenneth Kinzler

Affiliation Ludwig Center for Cancer Genetics and Therapeutics, Johns Hopkins Sidney Kimmel Cancer Center, Baltimore, Maryland, United States of America

Bert Vogelstein

Affiliations Ludwig Center for Cancer Genetics and Therapeutics, Johns Hopkins Sidney Kimmel Cancer Center, Baltimore, Maryland, United States of America, Howard Hughes Medical Institutions, Johns Hopkins Sidney Kimmel Cancer Center, Baltimore, Maryland, United States of America

Nickolas Papadopoulos

Affiliation Ludwig Center for Cancer Genetics and Therapeutics, Johns Hopkins Sidney Kimmel Cancer Center, Baltimore, Maryland, United States of America

Alan K. Meeker

Affiliation Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

for the ALT Starr Cancer Consortium

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: NP BV TdL JHJP WCH MJ NFL AKM. Performed the experiments: NP BV KK YJ CAL JB WL ST SR TdL SD JHJP BAW JR MH LM YZ EI WCH PAS CH. Analyzed the data: NP BV TdL JHJP WCH MJ NFL. Contributed reagents/materials/analysis tools: RRR. Wrote the paper: TdL JHJP WCH.