About the Authors

Caroline S. Fox

foxca@nhlbi.nih.gov (CSF); yoliu@wfubmc.edu (YL)

Affiliations Framingham Heart Study, National Heart, Lung, and Blood Institute, Framingham, Massachusetts, United States of America, Center for Population Studies, National Heart, Lung, and Blood Institute, Framingham, Massachusetts, United States of America, Division of Endocrinology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

Charles C. White

Affiliations Framingham Heart Study, National Heart, Lung, and Blood Institute, Framingham, Massachusetts, United States of America, Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America

Kurt Lohman

Affiliation Department of Epidemiology and Prevention, Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America

Nancy Heard-Costa

Affiliation Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, United States of America

Paul Cohen

Affiliation Division of Cardiovascular Medicine and Department of Cancer Biology, Brigham and Women's Hospital and Dana Farber Cancer Institute, Boston, Massachusetts, United States of America

Yingying Zhang

Affiliation Department of Cancer Biology, Dana Farber Cancer Institute, Boston, Massachusetts, United States of America

Andrew D. Johnson

Affiliations Framingham Heart Study, National Heart, Lung, and Blood Institute, Framingham, Massachusetts, United States of America, Center for Population Studies, National Heart, Lung, and Blood Institute, Framingham, Massachusetts, United States of America

Valur Emilsson

Affiliation Icelandic Heart Association, Hjartavernd, Iceland

Ching-Ti Liu

Affiliations Framingham Heart Study, National Heart, Lung, and Blood Institute, Framingham, Massachusetts, United States of America, Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America

Y.-D. Ida Chen

Affiliation Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America

Kent D. Taylor

Affiliation Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America

Matthew Allison

Affiliation Department of Preventive Medicine, University of California San Diego, La Jolla, California, United States of America

Matthew Budoff

Affiliation Los Angeles Biomedical Research Institute, Torrance, California, United States of America

The CARDIoGRAM Consortium
Jerome I. Rotter

Affiliation Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America

J. Jeffrey Carr

Affiliation Departments of Radiologic Sciences, Internal Medicine-Cardiology, and Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, North Carolina, United States of America

Udo Hoffmann

Affiliation Cardiac MR, PET, CT Program and the Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts, United States of America

Jingzhong Ding

Affiliation Department of Internal Medicine/Geriatrics, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America

L. Adrienne Cupples

Affiliations Framingham Heart Study, National Heart, Lung, and Blood Institute, Framingham, Massachusetts, United States of America, Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America

Yongmei Liu

foxca@nhlbi.nih.gov (CSF); yoliu@wfubmc.edu (YL)

Affiliation Department of Epidemiology and Prevention, Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Designed the study and drafted the manuscript: CSF YL. Performed the meta-analysis: CCW LAC. Performed the genetic correction analysis: C-TL. Performed the study-specific analyses: KL NH-C. Performed the functional studies: PC YZ. Performed the eQTL analyses: ADJ VE. Provided critical edits to the manuscript: Y-DIC KDT MA MB JIR JJC UH JD.