About the Authors

Janey L. Wiggs

Contributed equally to this work with: Janey L. Wiggs, Brian L. Yaspan

janey_wiggs@meei.harvard.edu

Affiliation Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, United States of America

Brian L. Yaspan

Contributed equally to this work with: Janey L. Wiggs, Brian L. Yaspan

Affiliation Vanderbilt University School of Medicine, Center for Human Genetics Research, Nashville, Tennessee, United States of America

Michael A. Hauser

Affiliation Duke University School of Medicine, Durham, North Carolina, United States of America

Jae H. Kang

Affiliation Department of Medicine and Channing Laboratory, Brigham and Women's Hospital, Boston, Massachusetts, United States of America

R. Rand Allingham

Affiliation Duke University School of Medicine, Durham, North Carolina, United States of America

Lana M. Olson

Affiliation Vanderbilt University School of Medicine, Center for Human Genetics Research, Nashville, Tennessee, United States of America

Wael Abdrabou

Affiliation Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, United States of America

Bao J. Fan

Affiliation Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, United States of America

Dan Y. Wang

Affiliation Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, United States of America

Wendy Brodeur

Affiliation Broad Institute of Harvard and Massachusetts Institute of Technology, Boston, Massachusetts, United States of America

Donald L. Budenz

Affiliation Department of Ophthalmology, University of North Carolina School of Medicine, Durham, North Carolina, United States of America

Joseph Caprioli

Affiliation Department of Ophthalmology, University of California Los Angeles, Los Angeles, California, United States of America

Andrew Crenshaw

Affiliation Broad Institute of Harvard and Massachusetts Institute of Technology, Boston, Massachusetts, United States of America

Kristy Crooks

Affiliation Duke University School of Medicine, Durham, North Carolina, United States of America

Elizabeth DelBono

Affiliation Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, United States of America

Kimberly F. Doheny

Affiliation Center for Inherited Disease Research, Johns Hopkins School of Medicine, Baltimore, Maryland, United States of America

David S. Friedman

Affiliation Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

Douglas Gaasterland

Affiliation Eye Doctors of Washington D.C., Washington D.C., United States of America

Terry Gaasterland

Affiliation Institute for Genomic Medicine and Marine Biology Research Division, University of California San Diego, San Diego, California, United States of America

Cathy Laurie

Affiliation Department of Biostatistics, University of Washington, Seattle, Washington, United States of America

Richard K. Lee

Affiliation Department of Ophthalmology, University of Miami, Miami, Florida, United States of America

Paul R. Lichter

Affiliation Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, Michigan, United States of America

Stephanie Loomis

Affiliations Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, United States of America, Department of Medicine and Channing Laboratory, Brigham and Women's Hospital, Boston, Massachusetts, United States of America

Yutao Liu

Affiliation Duke University School of Medicine, Durham, North Carolina, United States of America

Felipe A. Medeiros

Affiliation Department of Ophthalmology, University of California San Diego, San Diego, California, United States of America

Cathy McCarty

Affiliation Essentia Institute of Rural Health, Duluth, Minnesota, United States of America

Daniel Mirel

Affiliation Broad Institute of Harvard and Massachusetts Institute of Technology, Boston, Massachusetts, United States of America

Sayoko E. Moroi

Affiliation Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, Michigan, United States of America

David C. Musch

Affiliations Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, Michigan, United States of America, Department of Epidemiology, University of Michigan, Ann Arbor, Michigan, United States of America

Anthony Realini

Affiliation Department of Ophthalmology, West Virginia University School of Medicine, Morgantown, West Virginia, United States of America

Frank W. Rozsa

Affiliation Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, Michigan, United States of America

Joel S. Schuman

Affiliation Department of Ophthalmology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

Kathleen Scott

Affiliation Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, Michigan, United States of America

Kuldev Singh

Affiliation Department of Ophthalmology, Stanford University, Palo Alto, California, United States of America

Joshua D. Stein

Affiliation Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, Michigan, United States of America

Edward H. Trager

Affiliation Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, Michigan, United States of America

Paul VanVeldhuisen

Affiliation The EMMES Corporation, Rockville, Maryland, United States of America

Douglas Vollrath

Affiliation Department of Genetics, Stanford University, Palo Alto, California, United States of America

Gadi Wollstein

Affiliation Department of Ophthalmology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

Sachiko Yoneyama

Affiliations Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, Michigan, United States of America, Department of Epidemiology, University of Michigan, Ann Arbor, Michigan, United States of America

Kang Zhang

Affiliation Department of Ophthalmology, University of California San Diego, San Diego, California, United States of America

Robert N. Weinreb

Affiliation Department of Ophthalmology, University of California San Diego, San Diego, California, United States of America

Jason Ernst

Affiliations Broad Institute of Harvard and Massachusetts Institute of Technology, Boston, Massachusetts, United States of America, Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

Manolis Kellis

Affiliations Broad Institute of Harvard and Massachusetts Institute of Technology, Boston, Massachusetts, United States of America, Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

Tomohiro Masuda

Affiliation Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

Don Zack

Affiliation Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

Julia E. Richards

Affiliations Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, Michigan, United States of America, Department of Epidemiology, University of Michigan, Ann Arbor, Michigan, United States of America

Margaret Pericak-Vance

Affiliation Department of Human Genetics, University of Miami School of Medicine, Miami, Florida, United States of America

Louis R. Pasquale

These authors also contributed equally to this work.

Affiliations Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, United States of America, Department of Medicine and Channing Laboratory, Brigham and Women's Hospital, Boston, Massachusetts, United States of America

Jonathan L. Haines

These authors also contributed equally to this work.

Affiliation Vanderbilt University School of Medicine, Center for Human Genetics Research, Nashville, Tennessee, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JL Wiggs, BL Yaspan, MA Hauser, JH Kang, KF Doheny, C Laurie, D Mirel, D Zack, JE Richards, M Pericak-Vance, LR Pasquale, JL Haines. Performed the experiments: LM Olson, W Abdrabou, BJ Fan, DY Wang, W Brodeur, A Crenshaw, K Crooks, E DelBono, S Loomis, Y Liu, J Ernst, T Masuda. Analyzed the data: JL Wiggs, BL Yaspan, MA Hauser, JH Kang, LM Olson, BJ Fan, A Crenshaw, KF Doheny, C Laurie, S Loomis, D Mirel, DC Musch, P VanVeldhuisen, M Pericak-Vance, LR Pasquale, JL Haines. Contributed reagents/materials/analysis tools: RR Allingham, DL Budenz, J Caprioli, DS Friedman, D Gaasterland, T Gassterland, RK Lee, PR Lichter, FA Medeiros, C McCarty, SE Moroi, A Realini, FW Rozsa, JS Schuman, K Scott, K Singh, JD Stein, EH Trager, D Vollrath, G Wollstein, S Yoneyama, K Zhang, RN Weinreb, M Kellis, D Zack, JL Wiggs, LR Pasquale. Wrote the paper: JL Wiggs, BL Yaspan, MA Hauser, JH Kang, JE Richards, LR Pasquale, JL Haines.