About the Authors

Eimear E. Kenny, Itsik Pe'er
Department of Computer Sciences, Columbia University, New York, New York, United States of America

Amir Karban, Yehuda Chowers, Matti Waterman
Department of Gastroenterology, Rambam Health Care Campus, B. Rappaport Institute for Research in the Medical Sciences, Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel

Laurie Ozelius, Adele A. Mitchell, Monica Erazo, Dana Doheny, Robert J. Desnick, Inga Peter
Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, New York, United States of America

Sok Meng Ng, Clara Abraham, Deborah D. Proctor, Wei Zhang, Judy H. Cho
Department of Medicine, Section of Digestive Diseases, Yale University, New Haven, Connecticut, United States of America

Harry Ostrer
Department of Pathology, Albert Einstein College of Medicine, New York, New York, United States of America

Maria T. Abreu
Division of Gastroenterology, University of Miami Miller School of Medicine, Miami, Florida, United States of America

Gil Atzmon, Nir Barzilai
Genetic Core for Longevity, Institute for Aging Research and the Diabetes Research Center, Albert Einstein College of Medicine, Bronx, New York, United States of America

Steven R. Brant
Meyerhoff Inflammatory Bowel Disease Center, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

Steven R. Brant, Ann Pulver
Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, United States of America

Susan Bressman
Mirken Department of Neurology, Beth Israel Medical Center, New York, New York, United States of America

Susan Bressman
The Saul R. Korey Department of Neurology, Albert Einstein College of Medicine, Bronx, New York, United States of America

Edward R. Burns
Department of Medicine, Albert Einstein College of Medicine, Bronx, New York, United States of America

Lorraine N. Clark
Department of Pathology and Cell Biology, Columbia University, New York, New York, United States of America

Ariel Darvasi
The Institute of Life Sciences, Hebrew University of Jerusalem, Jerusalem, Israel

Richard H. Duerr
Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America

Richard H. Duerr
Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

Rami Eliakim
Department of Gastroenterology and Hepatology, Sheba Medical Center, Raman Gan, Israel

Nir Giladi
Department of Neurology, Tel Aviv Sourasky Medical Center, Sackler School of Medicine, Tel Aviv University, Tel-Aviv, Israel

Peter K. Gregersen
Robert S. Boas Center for Genomics and Human Genetics, Feinstein Institute for Medical Research, North Shore LIJ Health System, Manhasset, New York, United States of America

Hakon Hakonarson
Center for Applied Genomics, The Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

Michelle R. Jones
Division of Endocrinology, Diabetes, and Metabolism, Graduate Program in Biomedical Sciences and Translational Medicine, Cedars-Sinai Medical Center, Los Angeles, California, United States of America

Karen Marder
Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, New York, United States of America

Karen Marder
Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, New York, United States of America

Dermot P. B. McGovern
Department of Translational Medicine, Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America

Dermot P. B. McGovern, Jerome I. Rotter
Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America

Jennifer Mulle, Stephen T. Warren
Department of Human Genetics, Emory University School of Medicine, Atlanta, Georgia, United States of America

Avi Orr-Urtreger
Genetic Institute, Tel Aviv Sourasky Medical Center, Sackler School of Medicine, Tel Aviv University, Tel-Aviv, Israel

Ann Pulver
Epidemiology-Genetics Program in Schizophrenia, Bipolar Disorders, and Related Disorders, Department of Psychiatry and Behavioral Sciences, School of Medicine, Johns Hopkins University, Baltimore, Maryland, United States of America

Mark S. Silverberg
IBD Group, Mount Sinai Hospital, University of Toronto, Toronto, Canada

Thomas Ullman, Lloyd Mayer
Division of Gastroenterology, Department of Medicine, Mount Sinai School of Medicine, New York, New York, United States of America

Stephen T. Warren
Departments of Biochemistry and Pediatrics, Emory University School of Medicine, Atlanta, Georgia, United States of America

Aviv Bergman
Department of Systems and Computational Biology, Albert Einstein College of Medicine, New York, New York, United States of America

Seymour Katz
Albert Einstein College of Medicine, North Shore University Hospital-Long Island Jewish Hospital Systems, St. Francis Hospital, Great Neck, New York, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: I Peter, JH Cho, I Pe'er, EE Kenny, RJ Desnick. Performed the experiments: AA Mitchell, M Erazo, SM Ng, PK Gregersen, J Mulle. Analyzed the data: EE Kenny, I Pe'er, MR Jones, DPB McGovern. Contributed reagents/materials/analysis tools: A Karban, L Ozelius, H Ostrer, C Abraham, MT Abreu, G Atzmon, N Barzilai, SR Brant, S Bressman, ER Burns, Y Chowers, LN Clark, D Doheny, RH Duerr, R Eliakim, N Giladi, H Hakonarson, K Marder, DPB McGovern, A Orr-Urtreger, A Darvasi, DD Proctor, A Pulver JI Roter, MS Silverberg, T Ullman, ST Warren, M Waterman, W Zhang, A Bergman, L Mayer, S Katz, JH Cho, I Peter. Wrote the paper: I Peter, JH Cho, I Pe'er, EE Kenny.