Contrasting Properties of Gene-Specific Regulatory, Coding, and Copy Number Mutations in Saccharomyces cerevisiae: Frequency, Effects, and Dominance

Jonathan D. Gruber; Kara Vogel; Gizem Kalay; Patricia J. Wittkopp

doi:10.1371/journal.pgen.1002497

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Peer-reviewed

Research Article

Contrasting Properties of Gene-Specific Regulatory, Coding, and Copy Number Mutations in Saccharomyces cerevisiae: Frequency, Effects, and Dominance

Jonathan D. Gruber,

Affiliation Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, Michigan, United States of America
⨯
Kara Vogel,

Affiliation Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, Michigan, United States of America
⨯
Gizem Kalay,

Affiliation Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, Michigan, United States of America
⨯
Patricia J. Wittkopp

* E-mail: wittkopp@umich.edu

Affiliations Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, Michigan, United States of America, Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, Michigan, United States of America
⨯

Contrasting Properties of Gene-Specific Regulatory, Coding, and Copy Number Mutations in Saccharomyces cerevisiae: Frequency, Effects, and Dominance

Jonathan D. Gruber,
Kara Vogel,
Gizem Kalay,
Patricia J. Wittkopp

Published: February 9, 2012
https://doi.org/10.1371/journal.pgen.1002497

About the Authors

Jonathan D. Gruber

Affiliation Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, Michigan, United States of America

Kara Vogel

Affiliation Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, Michigan, United States of America

Gizem Kalay

Affiliation Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, Michigan, United States of America

Patricia J. Wittkopp

* E-mail: wittkopp@umich.edu

Affiliations Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, Michigan, United States of America, Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, Michigan, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: PJW JDG GK. Performed the experiments: JDG KV GK. Analyzed the data: JDG PJW KV GK. Contributed reagents/materials/analysis tools: JDG GK. Wrote the paper: PJW JDG.

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Yellow fluorescent protein
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Mutation
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Point mutation
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Saccharomyces cerevisiae
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Reporter genes
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