About the Authors

Ilya M. Alexandrov

Contributed equally to this work with: Ilya M. Alexandrov, Maria Ivshina

Affiliation Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

Maria Ivshina

Contributed equally to this work with: Ilya M. Alexandrov, Maria Ivshina

Affiliation Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

Dae Young Jung

Affiliation Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

Randall Friedline

Affiliation Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

Hwi Jin Ko

Affiliation Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

Mei Xu

Affiliation Research Computing, Information Service Department, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

Bryan O'Sullivan-Murphy

Affiliations Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America, Program in Gene Function and Expression, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

Rita Bortell

Affiliation Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

Yen-Tsung Huang

Affiliation Departments of Epidemiology and Biostatistics, Harvard University, Boston, Massachusetts, United States of America

Fumihiko Urano

Affiliations Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America, Program in Gene Function and Expression, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

Jason K. Kim

Affiliations Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America, Department of Medicine, Division of Endocrinology, Metabolism, and Diabetes, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

Joel D. Richter

joel.richter@umassmed.edu

Affiliation Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: IMA MI FU JKK JDR. Performed the experiments: IMA MI DYJ RF HJK BO-M RB. Analyzed the data: IMA MI RF FU MX Y-TH JKK JDR. Contributed reagents/materials/analysis tools: MX. Wrote the paper: IMA MI JDR.