About the Authors

Yingleong Chan

Contributed equally to this work with: Yingleong Chan, Oddgeir L. Holmen, Andrew Dauber, Timothy M. Frayling, Joel N. Hirschhorn, Michael N. Weedon

Affiliations Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America, Broad Institute, Cambridge, Massachusetts, United States of America, Children's Hospital Boston, Boston, Massachusetts, United States of America

Oddgeir L. Holmen

Contributed equally to this work with: Yingleong Chan, Oddgeir L. Holmen, Andrew Dauber, Timothy M. Frayling, Joel N. Hirschhorn, Michael N. Weedon

Affiliations HUNT Research Centre, Department of Public Health and General Practice, Norwegian University of Science and Technology, Levanger, Norway, St. Olav Hospital, Trondheim University Hospital, Trondheim, Norway

Andrew Dauber

Contributed equally to this work with: Yingleong Chan, Oddgeir L. Holmen, Andrew Dauber, Timothy M. Frayling, Joel N. Hirschhorn, Michael N. Weedon

Affiliations Broad Institute, Cambridge, Massachusetts, United States of America, Children's Hospital Boston, Boston, Massachusetts, United States of America

Lars Vatten

Affiliation Department of Public Health and General Practice, Norwegian University of Science and Technology, Trondheim, Norway

Aki S. Havulinna

Affiliation National Institute for Health and Welfare, Helsinki, Finland

Frank Skorpen

Affiliation Department of Laboratory Medicine, Children's and Women's Health, Norwegian University of Science and Technology, Trondheim, Norway

Kirsti Kvaløy

Affiliation HUNT Research Centre, Department of Public Health and General Practice, Norwegian University of Science and Technology, Levanger, Norway

Kaisa Silander

Affiliations National Institute for Health and Welfare, Helsinki, Finland, Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland

Thutrang T. Nguyen

Affiliation Children's Hospital Boston, Boston, Massachusetts, United States of America

Cristen Willer

Affiliation Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan, United States of America

Michael Boehnke

Affiliation Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan, United States of America

Markus Perola

Affiliations National Institute for Health and Welfare, Helsinki, Finland, Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland, Estonian Genome Project, University of Tartu, Tartu, Estonia

Aarno Palotie

Affiliations Broad Institute, Cambridge, Massachusetts, United States of America, Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom, Department of Medical Genetics, University of Helsinki and University Central Hospital, Helsinki, Finland

Veikko Salomaa

Affiliation National Institute for Health and Welfare, Helsinki, Finland

Kristian Hveem

Affiliation HUNT Research Centre, Department of Public Health and General Practice, Norwegian University of Science and Technology, Levanger, Norway

Timothy M. Frayling

Contributed equally to this work with: Yingleong Chan, Oddgeir L. Holmen, Andrew Dauber, Timothy M. Frayling, Joel N. Hirschhorn, Michael N. Weedon

Affiliation Genetics of Complex Traits, Peninsula Medical School, University of Exeter, Exeter, United Kingdom

Joel N. Hirschhorn

Contributed equally to this work with: Yingleong Chan, Oddgeir L. Holmen, Andrew Dauber, Timothy M. Frayling, Joel N. Hirschhorn, Michael N. Weedon

joelh@broadinstitute.org(JNH); michael.weedon@pms.ac.uk (MNW)

Affiliations Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America, Broad Institute, Cambridge, Massachusetts, United States of America, Children's Hospital Boston, Boston, Massachusetts, United States of America

Michael N. Weedon

Contributed equally to this work with: Yingleong Chan, Oddgeir L. Holmen, Andrew Dauber, Timothy M. Frayling, Joel N. Hirschhorn, Michael N. Weedon

joelh@broadinstitute.org(JNH); michael.weedon@pms.ac.uk (MNW)

Affiliation Genetics of Complex Traits, Peninsula Medical School, University of Exeter, Exeter, United Kingdom

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: YC OLH AD TMF JNH MNW. Performed the experiments: YC OLH AD LV ASH FS KK KS TTN CW MB MP AP VS KH TMF JNH MNW. Analyzed the data: YC OLH AD TMF JNH MNW. Contributed reagents/materials/analysis tools: LV ASH FS KK KS TTN CW MB MP AP VS KH. Wrote the paper: YC OLH AD TMF JNH MNW. Made revisions to the paper: YC OLH AD FS MB TMF JNH MNW.