About the Authors

Jingyuan Fu

fjingyuan@gmail.com (JF); lude@ludesign.nl (LF)

Affiliations Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands, Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

Marcel G. M. Wolfs

Affiliation Department of Pathology and Medical Biology, Molecular Genetics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

Patrick Deelen

Affiliation Hanze University Groningen, Groningen, The Netherlands

Harm-Jan Westra

Affiliation Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

Rudolf S. N. Fehrmann

Affiliations Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands, Department of Medical Oncology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

Gerard J. te Meerman

Affiliation Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

Wim A. Buurman

Affiliation Department of Surgery, University Hospital Maastricht and Nutrition and Toxicology Research Institute (NUTRIM), Maastricht University, Maastricht, The Netherlands

Sander S. M. Rensen

Affiliation Department of Surgery, University Hospital Maastricht and Nutrition and Toxicology Research Institute (NUTRIM), Maastricht University, Maastricht, The Netherlands

Harry J. M. Groen

Affiliation Department of Pulmonology, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands

Rinse K. Weersma

Affiliation Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

Leonard H. van den Berg

Affiliation Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands

Jan Veldink

Affiliation Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands

Roel A. Ophoff

Affiliation Department of Medical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands

Harold Snieder

Affiliation Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

David van Heel

Affiliation Blizard Institute of Cell and Molecular Science, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom

Ritsert C. Jansen

Affiliation Groningen Bioinformatics Centre, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Haren, The Netherlands

Marten H. Hofker

Affiliation Department of Pathology and Medical Biology, Molecular Genetics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

Cisca Wijmenga

Affiliation Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

Lude Franke

fjingyuan@gmail.com (JF); lude@ludesign.nl (LF)

Affiliation Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JF LF CW MHH. Wrote the paper: JF LF. Collected tissues: WAB SSMR HJMG RKW LHvdB JV DvH. Conducted genotyping: CW RAO. Conducted expression profiling: MGMW CW MHH. Bioinformatics and statistical analyses: JF PD H-JW LF. Bioinformatics support: RCJ. PCA-based normalization: RSNF GJtM LF. Helped to improve the manuscript: HS RCJ CW.