About the Authors

Elena Lissina

Affiliations Department of Molecular Genetics, University of Toronto, Toronto, Canada, Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Canada

Brian Young

Affiliation Department of Chemistry and Biochemistry and the Molecular Biology Institute, University of California Los Angeles, Los Angeles, California, United States of America

Malene L. Urbanus

Affiliations Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Canada, Banting and Best Department of Medical Research, University of Toronto, Toronto, Canada

Xue Li Guan

Affiliations Department of Biological Sciences, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore, Department of Biochemistry, University of Geneva, Geneva, Switzerland

Jonathan Lowenson

Affiliation Department of Chemistry and Biochemistry and the Molecular Biology Institute, University of California Los Angeles, Los Angeles, California, United States of America

Shawn Hoon

Affiliation Molecular Engineering Lab, Agency for Science, Technology, and Research, Singapore, Singapore

Anastasia Baryshnikova

Affiliations Department of Molecular Genetics, University of Toronto, Toronto, Canada, Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Canada

Isabelle Riezman

Affiliation Department of Biochemistry, University of Geneva, Geneva, Switzerland

Magali Michaut

Affiliation Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Canada

Howard Riezman

Affiliation Department of Biochemistry, University of Geneva, Geneva, Switzerland

Leah E. Cowen

Affiliation Department of Molecular Genetics, University of Toronto, Toronto, Canada

Markus R. Wenk

Affiliation Department of Biological Sciences, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore

Steven G. Clarke

Affiliation Department of Chemistry and Biochemistry and the Molecular Biology Institute, University of California Los Angeles, Los Angeles, California, United States of America

Guri Giaever

Affiliations Department of Molecular Genetics, University of Toronto, Toronto, Canada, Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Canada, Department of Pharmacy and Pharmaceutical Sciences, University of Toronto, Toronto, Canada

Corey Nislow

corey.nislow@utoronto.ca

Affiliations Department of Molecular Genetics, University of Toronto, Toronto, Canada, Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Canada, Banting and Best Department of Medical Research, University of Toronto, Toronto, Canada

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: EL BY JL MLU SGC GG CN. Performed the experiments: EL BY XLG IR. Analyzed the data: EL BY XLG HR GG CN. Contributed reagents/materials/analysis tools: MLU AB JL SH MM MRW HR LEC. Wrote the paper: EL GG CN.