Release of Ku and MRN from DNA Ends by Mre11 Nuclease Activity and Ctp1 Is Required for Homologous Recombination Repair of Double-Strand Breaks

Petra Langerak; Eva Mejia-Ramirez; Oliver Limbo; Paul Russell

doi:10.1371/journal.pgen.1002271

Loading metrics

Open Access

Peer-reviewed

Research Article

Release of Ku and MRN from DNA Ends by Mre11 Nuclease Activity and Ctp1 Is Required for Homologous Recombination Repair of Double-Strand Breaks

Petra Langerak,

Affiliation Department of Molecular Biology, The Scripps Research Institute, La Jolla, California, United States of America
⨯
Eva Mejia-Ramirez,

Affiliation Department of Molecular Biology, The Scripps Research Institute, La Jolla, California, United States of America
⨯
Oliver Limbo,

Affiliation Department of Molecular Biology, The Scripps Research Institute, La Jolla, California, United States of America
⨯
Paul Russell

* E-mail: prussell@scripps.edu

Affiliation Department of Molecular Biology, The Scripps Research Institute, La Jolla, California, United States of America
⨯

Release of Ku and MRN from DNA Ends by Mre11 Nuclease Activity and Ctp1 Is Required for Homologous Recombination Repair of Double-Strand Breaks

Petra Langerak,
Eva Mejia-Ramirez,
Oliver Limbo,
Paul Russell

Published: September 8, 2011
https://doi.org/10.1371/journal.pgen.1002271

About the Authors

Petra Langerak

Affiliation Department of Molecular Biology, The Scripps Research Institute, La Jolla, California, United States of America

Eva Mejia-Ramirez

Affiliation Department of Molecular Biology, The Scripps Research Institute, La Jolla, California, United States of America

Oliver Limbo

Affiliation Department of Molecular Biology, The Scripps Research Institute, La Jolla, California, United States of America

Paul Russell

* E-mail: prussell@scripps.edu

Affiliation Department of Molecular Biology, The Scripps Research Institute, La Jolla, California, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: PL EM-R. Performed the experiments: PL EM-R OL. Analyzed the data: PL EM-R OL. Contributed reagents/materials/analysis tools: PL EM-R OL. Wrote the paper: PL PR.

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Recombinase polymerase amplification
Is the Subject Area "Recombinase polymerase amplification" applicable to this article?

Thanks for your feedback.
Nucleases
Is the Subject Area "Nucleases" applicable to this article?

Thanks for your feedback.
DNA repair
Is the Subject Area "DNA repair" applicable to this article?

Thanks for your feedback.
Saccharomyces cerevisiae
Is the Subject Area "Saccharomyces cerevisiae" applicable to this article?

Thanks for your feedback.
Schizosaccharomyces pombe
Is the Subject Area "Schizosaccharomyces pombe" applicable to this article?

Thanks for your feedback.
Non-homologous end joining
Is the Subject Area "Non-homologous end joining" applicable to this article?

Thanks for your feedback.
DNA damage
Is the Subject Area "DNA damage" applicable to this article?

Thanks for your feedback.
DNA recombination
Is the Subject Area "DNA recombination" applicable to this article?

Thanks for your feedback.