About the Authors

Ching-Ti Liu, Xiaoning Lu
Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America

Maija K. Garnaas
Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

Maija K. Garnaas, Wolfram Goessling, W. Linda Kao
Harvard Stem Cell Institute, Harvard University, Cambridge, Massachusetts, United States of America

Adrienne Tin, Anna Kottgen, Man Li
Department of Epidemiology, Johns Hopkins University, Baltimore, Maryland, United States of America

Anna Kottgen
Renal Division, University Hospital of Freiburg, Freiburg, Germany

Nora Franceschini
Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

Carmen A. Peralta
Division of Nephrology, University of California San Francisco Medical School and San Francisco VA Medical Center, San Francisco, California, United States of America

Ian H. de Boer
Division of Nephrology and Kidney Research Institute, University of Washington, Seattle, Washington, United States of America

Elizabeth Atkinson, Mariza de Andrade
Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota, United States of America

Jingzhong Ding
Gerontology and Geriatric Medicine, J. Paul Sticht Center on Aging, Wake Forest University Health Sciences, Winston-Salem, North Carolina, United States of America

Michael Nalls
Laboratory of Neurogenetics, National Institute of Aging, National Institutes of Health, Bethesda, Maryland, United States of America

Daniel Shriner, Adebowale Adeyemo, Charles N. Rotimi
Center for Research on Genomics and Global Health, National Human Genome Research Institute, Bethesda, Maryland, United States of America

Josef Coresh
Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins University, Baltimore, Maryland, United States of America

Abdullah Kutlar
Medical College of Georgia, Augusta, Georgia, United States of America

Kirsten Bibbins-Domingo
University of California San Francisco, San Francisco, California, United States of America

David Siscovick
Cardiovascular Health Research Unit, Departments of Epidemiology and Medicine, University of Washington, Seattle, Washington, United States of America

Ermeg Akylbekova
Jackson State University, Jackson, Mississippi, United States of America

Sharon Wyatt
School of Nursing, University of Mississippi Medical Center, Jackson, Mississippi, United States of America

Brad Astor
Department of Epidemiology, Bloomberg School of Public Health, Baltimore, Maryland, United States of America

Josef Mychaleckjy
Center for Public Health Genomics, Charlottesville, Virginia, United States of America

Muredach P. Reilly
Cardiovascular Institute, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

Raymond R. Townsend
Renal Electrolyte and Hypertension Division, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

Alan B. Zonderman
Laboratory of Personality and Cognition, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America

Stephen T. Turner
Department of Internal Medicine, Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota, United States of America

Thomas H. Mosley
Division of Geriatrics, Department of Medicine, University of Mississippi Medical Center, Jackson, Mississippi, United States of America

Tamara B. Harris
Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America

Yongmei Liu
Department of Epidemiology and Prevention, Division of Public Health Sciences, Wake Forest University, Winston-Salem, North Carolina, United States of America

Sharon L. R. Kardia
Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, Michigan, United States of America

Michele K. Evans
Health Disparities Research Section, Clinical Research Branch, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America

Michael G. Shlipak
General Internal Medicine, University of California San Francisco, San Francisco, California, United States of America

Holly Kramer
Loyola University, Maywood, Illinois, United States of America

Michael F. Flessner
Division of Kidney, Urologic, and Hematologic Diseases, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

Albert W. Dreisbach
University of Mississippi Division of Nephrology, University of Mississippi, Jackson, Mississippi, United States of America

Wolfram Goessling
Divisions of Genetics and Gastroenterology, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

L. Adrienne Cupples
Department of Biostatistics, Boston University School of Public Health and National Heart, Blood, and Lung Institute's Framingham Heart Study, Boston, Massachusetts, United States of America

Caroline S. Fox
National Heart, Blood, and Lung Institute's Framingham Heart Study and the Center for Population Studies, Framingham, Massachusetts, United States of America

Caroline S. Fox
Division of Endocrinology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: A Adeyemo, CN Rotimi, MK Evans, AB Zonderman, Y Liu, TB Harris, J Ding, SLR Kardia, WL Kao, CS Fox. Performed the experiments: A Adeyemo, CN Rotimi, MK Evans, AB Zonderman, Y Liu, TB Harris, J Ding, SLR Kardia, ST Turner, J Coresh, D Shriner, MG Shlipak, H Kramer, AW Dreisbach, WL Kao, CS Fox. Analyzed the data: A Adeyemo, D Shriner, AB Zonderman, M Nalls, Y Liu, TB Harris, J Ding, SLR Kardia, M de Andrade, ST Turner, E Akylbekova, MF Flessner, C-T Liu, A Tin, A Kottgen, N Francheschini, CA Peralta, IH de Boer, X Lu, M Li, AW Dreisbach, LA Cupples, WL Kao, CS Fox. Wrote the paper: SLR Kardia, MF Flessner, MK Garnaas, W Goessling, C-T Liu, A Tin, A Kottgen, N Francheschini, CA Peralta, IH de Boer, LA Cupples, WL Kao, CS Fox. Subject recruitment: A Adeyemo, CN Rotimi, MK Evans, AB Zonderman, TB Harris, ST Turner, J Coresh,, D Siscovick, WL Kao, CS Fox. Critical review of manuscript: CS Fox C-T Liu, MK Garnaas, A Tin, A Kottgen, N Franceschini, CA Peralta, IH de Boer, X Lu, E Atkinson, J Ding, M Nalls, D Shriner, J Coresh, A Kutlar, K Bibbins-Domingo, D Siscovick, E Akylbekova, S Wyatt, B Astor, J Mychaleckjy, M Li, MP Reilly, RR Townsend, A Adeyemo, AB Zonderman, M de Andrade, ST Turner, TH Mosley, TB Harris, CKDGen Consortium, CN Rotimi, Y Liu, SLR Kardia, MK Evans, MG Shlipak, H Kramer, MF Flessner, AW Dreisbach, W Goessling, LA Cupples, WL Kao. Statistical methods and analysis: A Adeyemo, D Shriner, M Nalls, Y Liu, J Ding, M de Andrade, E Akylbekova, SLR Kardia, MK Garnaas, W Goessling, C-T Liu, A Tin, A Kottgen, X Lu, E Atkinson, M Li, LA Cupples WL Kao, CS Fox. Genotyping: A Adeyemo, D Shriner, M Nalls, Y Liu, M de Andrade, LA Cupples, WL Kao. Bioinformatics: M Nalls, C-T Liu. Zebrafish Work: MK Garnaas, W Goessling. Study management: D Siscovick.