About the Authors

Serena Sanna

Contributed equally to this work with: Serena Sanna, Bingshan Li, Antonella Mulas

goncalo@umich.edu (GRA); serena.sanna@inn.cnr.it (SS)

Affiliation Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Monserrato, Italy

Bingshan Li

Contributed equally to this work with: Serena Sanna, Bingshan Li, Antonella Mulas

Affiliation Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, United States of America

Antonella Mulas

Contributed equally to this work with: Serena Sanna, Bingshan Li, Antonella Mulas

Affiliation Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Monserrato, Italy

Carlo Sidore

Affiliations Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Monserrato, Italy, Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, United States of America, Dipartimento di Scienze Biomediche, Università di Sassari, Sassari, Italy

Hyun M. Kang

Affiliation Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, United States of America

Anne U. Jackson

Affiliation Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, United States of America

Maria Grazia Piras

Affiliation Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Monserrato, Italy

Gianluca Usala

Affiliation Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Monserrato, Italy

Giuseppe Maninchedda

Affiliation Shardna Life Sciences, Pula, Italy

Alessandro Sassu

Affiliation Shardna Life Sciences, Pula, Italy

Fabrizio Serra

Affiliation Shardna Life Sciences, Pula, Italy

Maria Antonietta Palmas

Affiliation Shardna Life Sciences, Pula, Italy

William H. Wood III

Affiliation Gene Expression and Genomics Unit, Research Resources Branch, National Institute on Aging, Baltimore, Maryland, United States of America

Inger Njølstad

Affiliation Department of Community Medicine, Faculty of Health Sciences, University of Tromso, Tromso, Norway

Markku Laakso

Affiliation Department of Medicine, University of Eastern Finland, Kuopio, Finland

Kristian Hveem

Affiliation Department of Public Health, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway

Jaakko Tuomilehto

Affiliations Diabetes Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland, Hjelt Institute, Department of Public Health, University of Helsinki, Helsinki, Finland, South Ostrobothnia Central Hospital, Seinajoki, Finland

Timo A. Lakka

Affiliations Institute of Biomedicine/Physiology, University of Eastern Finland, Kuopio, Finland, Kuopio Research Institute of Exercise Medicine, Kuopio, Finland

Rainer Rauramaa

Affiliation Kuopio Research Institute of Exercise Medicine, Kuopio, Finland

Michael Boehnke

Affiliation Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, United States of America

Francesco Cucca

Affiliations Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Monserrato, Italy, Dipartimento di Scienze Biomediche, Università di Sassari, Sassari, Italy

Manuela Uda

Affiliation Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Monserrato, Italy

David Schlessinger

These authors also contributed equally to this work.

Affiliation Laboratory of Genetics, National Institute on Aging, Baltimore, Maryland, United States of America

Ramaiah Nagaraja

These authors also contributed equally to this work.

Affiliation Laboratory of Genetics, National Institute on Aging, Baltimore, Maryland, United States of America

Gonçalo R. Abecasis

goncalo@umich.edu (GRA); serena.sanna@inn.cnr.it (SS)

These authors also contributed equally to this work.

Affiliation Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SS GRA DS. Performed the experiments: AM WHW RN GU. Analyzed the data: SS BL CS AUJ. Contributed reagents/materials/analysis tools: MU DS GRA. Wrote the paper: SS GRA. Contributed to genotyping chip design: BL HMK GRA. Collected phenotypes: MGP. Provided replication samples: GM AS FS MAP IN ML KH JT MB TAL RR. Provided critical revisions: BL AM FC MU DS RN MB.