About the Authors

Alexander P. Reiner

Contributed equally to this work with: Alexander P. Reiner, Guillaume Lettre, Michael A. Nalls, Santhi K. Ganesh, Rasika Mathias, Melissa A. Austin, Eric Dean

apreiner@u.washington.edu (APR); jgwilson2@umc.edu (JGW)

Affiliations Department of Epidemiology, University of Washington, Seattle, Washington, United States of America, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

Guillaume Lettre

Contributed equally to this work with: Alexander P. Reiner, Guillaume Lettre, Michael A. Nalls, Santhi K. Ganesh, Rasika Mathias, Melissa A. Austin, Eric Dean

Affiliations Montreal Heart Institute, Montréal, Canada, Département de Médecine, Université de Montréal, Montréal, Canada

Michael A. Nalls

Contributed equally to this work with: Alexander P. Reiner, Guillaume Lettre, Michael A. Nalls, Santhi K. Ganesh, Rasika Mathias, Melissa A. Austin, Eric Dean

Affiliation Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America

Santhi K. Ganesh

Contributed equally to this work with: Alexander P. Reiner, Guillaume Lettre, Michael A. Nalls, Santhi K. Ganesh, Rasika Mathias, Melissa A. Austin, Eric Dean

Affiliation Division of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, United States of America

Rasika Mathias

Contributed equally to this work with: Alexander P. Reiner, Guillaume Lettre, Michael A. Nalls, Santhi K. Ganesh, Rasika Mathias, Melissa A. Austin, Eric Dean

Affiliation Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

Melissa A. Austin

Contributed equally to this work with: Alexander P. Reiner, Guillaume Lettre, Michael A. Nalls, Santhi K. Ganesh, Rasika Mathias, Melissa A. Austin, Eric Dean

Affiliations Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America, Department of Epidemiology and Institute for Public Health Genetics, School of Public Health, University of Washington, Seattle, Washington, United States of America

Eric Dean

Contributed equally to this work with: Alexander P. Reiner, Guillaume Lettre, Michael A. Nalls, Santhi K. Ganesh, Rasika Mathias, Melissa A. Austin, Eric Dean

Affiliation Department of Medicine, University of California San Francisco, San Francisco, California, United States of America

Sampath Arepalli

Affiliation Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America

Angela Britton

Affiliation Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America

Zhao Chen

Affiliation Division of Epidemiology and Biostatistics, Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, Arizona, United States of America

David Couper

Affiliation Department of Epidemiology, University of North Carolina School of Public Health, Chapel Hill, North Carolina, United States of America

J. David Curb

Affiliation Department of Geriatric Medicine, John A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii, United States of America

Charles B. Eaton

Affiliation Center for Primary Care and Prevention, Alpert Medical School of Brown University, Providence, Rhode Island, United States of America

Myriam Fornage

Affiliation Houston Institute of Molecular Medicine, University of Texas, Houston, Texas, United States of America

Struan F. A. Grant

Affiliation Center for Applied Genomics, Division of Human Genetics, Children's Hospital of Philadelphia Research Institute, Philadelphia, Pennsylvania, United States of America

Tamara B. Harris

Affiliation Laboratory for Epidemiology, Demography, and Biometry, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America

Dena Hernandez

Affiliation Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America

Naoyuki Kamatini

Affiliation Laboratory for Statistical Analysis, Center for Genomic Medicine (CGM), Institute of Physical and Chemical Research (RIKEN), Yokohama, Japan

Brendan J. Keating

Affiliation Center for Applied Genomics, Division of Human Genetics, Children's Hospital of Philadelphia Research Institute, Philadelphia, Pennsylvania, United States of America

Michiaki Kubo

Affiliation Laboratory for Genotyping Development, CGM, RIKEN, Yokohama, Japan

Andrea LaCroix

Affiliations Department of Epidemiology, University of Washington, Seattle, Washington, United States of America, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

Leslie A. Lange

Affiliation Department of Genetics, University of North Carolina, Chapel Hill, North Carolina, United States of America

Simin Liu

Affiliation Departments of Epidemiology and Medicine, University of California Los Angeles, Los Angeles, California, United States of America

Kurt Lohman

Affiliation Center for Human Genomics, Department of Epidemiology and Prevention, Division of Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, North Carolina, United States of America

Yan Meng

Affiliation Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, United States of America

Emile R. Mohler III

Affiliation Cardiovascular Division, Vascular Medicine Section, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

Solomon Musani

Affiliation Department of Medicine, University of Mississippi Medical Center, Jackson, Mississippi, United States of America

Yusuke Nakamura

Affiliation Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan

Christopher J. O'Donnell

Affiliations National Heart, Lung, and Blood Institute (NHLBI), Division of Cardiovascular Sciences, Bethesda, Maryland, United States of America, NHLBI's Framingham Heart Study, Framingham, Massachusetts, United States of America

Yukinori Okada

Affiliation Laboratory for Statistical Analysis, Center for Genomic Medicine (CGM), Institute of Physical and Chemical Research (RIKEN), Yokohama, Japan

Cameron D. Palmer

Affiliation Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, United States of America

George J. Papanicolaou

Affiliation National Heart, Lung, and Blood Institute (NHLBI), Division of Cardiovascular Sciences, Bethesda, Maryland, United States of America

Kushang V. Patel

Affiliation Laboratory for Epidemiology, Demography, and Biometry, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America

Andrew B. Singleton

Affiliation Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America

Atsushi Takahashi

Affiliation Laboratory for Statistical Analysis, Center for Genomic Medicine (CGM), Institute of Physical and Chemical Research (RIKEN), Yokohama, Japan

Hua Tang

Affiliation Department of Genetics, Stanford University School of Medicine, Stanford, California, United States of America

Herman A. Taylor Jr.

Affiliations Jackson State University, Tougaloo College, Jackson, Mississippi, United States of America, Department of Medicine, University of Mississippi Medical Center, Jackson, Mississippi, United States of America

Kent Taylor

Affiliation Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America

Cynthia Thomson

Affiliation Nutritional Sciences, Arizona Cancer Center, University of Arizona, Tucson, Arizona, United States of America

Lisa R. Yanek

Affiliation Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

Lingyao Yang

Affiliation Department of Biostatistical Sciences, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America

Elad Ziv

Affiliation Department of Medicine, University of California San Francisco, San Francisco, California, United States of America

Alan B. Zonderman

Affiliation Laboratory of Personality and Cognition, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America

Aaron R. Folsom

These authors also contributed equally to this work.

Affiliation Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota, United States of America

Michele K. Evans

These authors also contributed equally to this work.

Affiliation Health Disparities Research Section, Clinical Research Branch, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America

Yongmei Liu

These authors also contributed equally to this work.

Affiliation Center for Human Genomics, Department of Epidemiology and Prevention, Division of Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, North Carolina, United States of America

Diane M. Becker

These authors also contributed equally to this work.

Affiliation Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

Beverly M. Snively

These authors also contributed equally to this work.

Affiliation Department of Biostatistical Sciences, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America

James G. Wilson

apreiner@u.washington.edu (APR); jgwilson2@umc.edu (JGW)

Affiliation Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: APR GL MAN SKG RM MAA ED SA AB ZC DC JDC CBE MF SFAG TBH DH NK BJK MK AL LAL SL KL YM ERM SM YN CJO YO CDP GP KP ABS AT HT HAT KT CT LRY LY EZ ABZ ARF MKE YL DMB BMS JGW. Performed the experiments: APR GL MAN RM SA AB NK KL YM CDP YL LRY. Analyzed the data: APR GL MAN RM YM CDP LRY LY BMS. Contributed reagents/materials/analysis tools: APR GL MAN SKG RM MAA ED SA AB ZC DC JDC CBE MF SFAG TBH DH NK BJK MK AL LAL SL KL YM ERM SM YN CJO YO CDP GP KP ABS AT HT HAT KT CT LRY LY EZ ABZ ARF MKE YL DMB BMS JGW. Wrote the paper: APR JGW.