About the Authors

Alexander P. Reiner, Andrea LaCroix
Department of Epidemiology, University of Washington, Seattle, Washington, United States of America

Alexander P. Reiner, Melissa A. Austin, Andrea LaCroix
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

Guillaume Lettre
Montreal Heart Institute, Montréal, Canada

Guillaume Lettre
Département de Médecine, Université de Montréal, Montréal, Canada

Michael A. Nalls, Sampath Arepalli, Angela Britton, Dena Hernandez, Andrew B. Singleton
Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America

Santhi K. Ganesh
Division of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, United States of America

Rasika Mathias, Lisa R. Yanek, Diane M. Becker
Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

Melissa A. Austin
Department of Epidemiology and Institute for Public Health Genetics, School of Public Health, University of Washington, Seattle, Washington, United States of America

Eric Dean, Elad Ziv
Department of Medicine, University of California San Francisco, San Francisco, California, United States of America

Zhao Chen
Division of Epidemiology and Biostatistics, Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, Arizona, United States of America

David Couper
Department of Epidemiology, University of North Carolina School of Public Health, Chapel Hill, North Carolina, United States of America

J. David Curb
Department of Geriatric Medicine, John A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii, United States of America

Charles B. Eaton
Center for Primary Care and Prevention, Alpert Medical School of Brown University, Providence, Rhode Island, United States of America

Myriam Fornage
Houston Institute of Molecular Medicine, University of Texas, Houston, Texas, United States of America

Struan F. A. Grant, Brendan J. Keating
Center for Applied Genomics, Division of Human Genetics, Children's Hospital of Philadelphia Research Institute, Philadelphia, Pennsylvania, United States of America

Tamara B. Harris, Kushang V. Patel
Laboratory for Epidemiology, Demography, and Biometry, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America

Naoyuki Kamatini, Yukinori Okada, Atsushi Takahashi
Laboratory for Statistical Analysis, Center for Genomic Medicine (CGM), Institute of Physical and Chemical Research (RIKEN), Yokohama, Japan

Michiaki Kubo
Laboratory for Genotyping Development, CGM, RIKEN, Yokohama, Japan

Leslie A. Lange
Department of Genetics, University of North Carolina, Chapel Hill, North Carolina, United States of America

Simin Liu
Departments of Epidemiology and Medicine, University of California Los Angeles, Los Angeles, California, United States of America

Kurt Lohman, Yongmei Liu
Center for Human Genomics, Department of Epidemiology and Prevention, Division of Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, North Carolina, United States of America

Yan Meng, Cameron D. Palmer
Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, United States of America

Emile R. Mohler III
Cardiovascular Division, Vascular Medicine Section, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

Solomon Musani
Department of Medicine, University of Mississippi Medical Center, Jackson, Mississippi, United States of America

Yusuke Nakamura
Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan

Christopher J. O'Donnell, George J. Papanicolaou
National Heart, Lung, and Blood Institute (NHLBI), Division of Cardiovascular Sciences, Bethesda, Maryland, United States of America

Christopher J. O'Donnell
NHLBI's Framingham Heart Study, Framingham, Massachusetts, United States of America

Hua Tang
Department of Genetics, Stanford University School of Medicine, Stanford, California, United States of America

Herman A. Taylor Jr.
Jackson State University, Tougaloo College, Jackson, Mississippi, United States of America

Herman A. Taylor Jr.
Department of Medicine, University of Mississippi Medical Center, Jackson, Mississippi, United States of America

Kent Taylor
Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America

Cynthia Thomson
Nutritional Sciences, Arizona Cancer Center, University of Arizona, Tucson, Arizona, United States of America

Lingyao Yang, Beverly M. Snively
Department of Biostatistical Sciences, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America

Alan B. Zonderman
Laboratory of Personality and Cognition, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America

Aaron R. Folsom
Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota, United States of America

Michele K. Evans
Health Disparities Research Section, Clinical Research Branch, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America

James G. Wilson
Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: APR GL MAN SKG RM MAA ED SA AB ZC DC JDC CBE MF SFAG TBH DH NK BJK MK AL LAL SL KL YM ERM SM YN CJO YO CDP GP KP ABS AT HT HAT KT CT LRY LY EZ ABZ ARF MKE YL DMB BMS JGW. Performed the experiments: APR GL MAN RM SA AB NK KL YM CDP YL LRY. Analyzed the data: APR GL MAN RM YM CDP LRY LY BMS. Contributed reagents/materials/analysis tools: APR GL MAN SKG RM MAA ED SA AB ZC DC JDC CBE MF SFAG TBH DH NK BJK MK AL LAL SL KL YM ERM SM YN CJO YO CDP GP KP ABS AT HT HAT KT CT LRY LY EZ ABZ ARF MKE YL DMB BMS JGW. Wrote the paper: APR JGW.