About the Authors

Federico Innocenti, Mark J. Ratain
Cancer Research Center, Committee on Clinical Pharmacology and Pharmacogenomics, Department of Medicine, The University of Chicago, Chicago, Illinois, United States of America

Gregory M. Cooper, Ian B. Stanaway, Joshua D. Smith, Deborah A. Nickerson, Mark J. Rieder
Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America

Eric R. Gamazon, Nancy J. Cox
Section of Genetic Medicine, Department of Medicine, The University of Chicago, Chicago, Illinois, United States of America

Snezana Mirkov, Jacqueline Ramirez, Wanqing Liu
Section of Hematology/Oncology, Department of Medicine, The University of Chicago, Chicago, Illinois, United States of America

Yvonne S. Lin, Ken E. Thummel, Allan E. Rettie
Department of Medicinal Chemistry, School of Pharmacy, University of Washington, Seattle, Washington, United States of America

Yvonne S. Lin, Ken E. Thummel
Department of Pharmaceutics, University of Washington, Seattle, Washington, United States of America

Cliona Moloney
Merck Research Laboratories, Boston, Massachusetts, United States of America

Shelly Force Aldred, Nathan D. Trinklein
SwitchGear Genomics, Menlo Park, California, United States of America

Erin Schuetz
Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America

Christopher D. Brown
Institute for Genomics and Systems Biology, The University of Chicago and Argonne National Laboratory, Chicago, Illinois, United States of America

Christopher D. Brown
Departments of Human Genetics and Ecology and Evolution, The University of Chicago, Chicago, Illinois, United States of America

Corresponding Author

caseybrown@uchicago.edu

Competing Interests

The authors ND Trinklein and SF Aldred are employees of and hold stock in SwitchGear Genomics. SwitchGear Genomics sells reporter vectors commercially and is the owner by assignment of patents or patent applications related to the reporter platform. The author C Moloney is an employee of Merck Research Labs.

Author Contributions

Conceived and designed the experiments: F Innocenti, GM Cooper, E Schuetz, DA Nickerson, KE Thummel, MJ Rieder, AE Rettie, MJ Ratain, NJ Cox, CD Brown. Wrote the paper: GM Cooper, CD Brown. Initiated and administered tissue collection, storage, and sample data collection: YS Lin, E Schuetz, KE Thummel. Provided assistance with Merck data: C Moloney. Provided molecular biology technical support: JD Smith, S Mirkov, J Ramirez, W Liu. Provided bioinformatic support: IB Stanaway, ER Gamazon. Performed genotype imputation and regression analyses: GM Cooper, IB Stanaway, CD Brown. Generated and analyzed gene expression and genotyping data: GM Cooper, IB Stanaway, JD Smith, MJ Rieder, CD Brown. Performed replication analyses: GM Cooper, CD Brown. Generated and analyzed probe, promoter, and UTR resequencing data: GM Cooper, JD Smith, DA Nickerson, MJ Rieder. Performed SGG cloning and reporter assays: SF Aldred, ND Trinklein. Incorporated data into SCAN database: ER Gamazon, NJ Cox. Edited the paper: F Innocenti, GM Cooper, IB Stanaway, ER Gamazon, JD Smith, S Mirkov, J Ramirez, W Liu, YS Lin, C Moloney, SF Aldred, ND Trinklein, E Schuetz, DA Nickerson, KE Thummel, MJ Rieder, AE Rettie, MJ Ratain, NJ Cox, CD Brown.