About the Authors

Federico Innocenti

Contributed equally to this work with: Federico Innocenti, Gregory M. Cooper

Affiliation Cancer Research Center, Committee on Clinical Pharmacology and Pharmacogenomics, Department of Medicine, The University of Chicago, Chicago, Illinois, United States of America

Gregory M. Cooper

Contributed equally to this work with: Federico Innocenti, Gregory M. Cooper

Address Current address: Hudson Alpha Institute, Huntsville, Alabama, United States of America

Affiliation Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America

Ian B. Stanaway

Affiliation Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America

Eric R. Gamazon

Affiliation Section of Genetic Medicine, Department of Medicine, The University of Chicago, Chicago, Illinois, United States of America

Joshua D. Smith

Affiliation Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America

Snezana Mirkov

Affiliation Section of Hematology/Oncology, Department of Medicine, The University of Chicago, Chicago, Illinois, United States of America

Jacqueline Ramirez

Affiliation Section of Hematology/Oncology, Department of Medicine, The University of Chicago, Chicago, Illinois, United States of America

Wanqing Liu

Affiliation Section of Hematology/Oncology, Department of Medicine, The University of Chicago, Chicago, Illinois, United States of America

Yvonne S. Lin

Affiliations Department of Medicinal Chemistry, School of Pharmacy, University of Washington, Seattle, Washington, United States of America, Department of Pharmaceutics, University of Washington, Seattle, Washington, United States of America

Cliona Moloney

Affiliation Merck Research Laboratories, Boston, Massachusetts, United States of America

Shelly Force Aldred

Affiliation SwitchGear Genomics, Menlo Park, California, United States of America

Nathan D. Trinklein

Affiliation SwitchGear Genomics, Menlo Park, California, United States of America

Erin Schuetz

Affiliation Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America

Deborah A. Nickerson

Affiliation Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America

Ken E. Thummel

Affiliations Department of Medicinal Chemistry, School of Pharmacy, University of Washington, Seattle, Washington, United States of America, Department of Pharmaceutics, University of Washington, Seattle, Washington, United States of America

Mark J. Rieder

Affiliation Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America

Allan E. Rettie

Affiliation Department of Medicinal Chemistry, School of Pharmacy, University of Washington, Seattle, Washington, United States of America

Mark J. Ratain

Affiliation Cancer Research Center, Committee on Clinical Pharmacology and Pharmacogenomics, Department of Medicine, The University of Chicago, Chicago, Illinois, United States of America

Nancy J. Cox

Affiliation Section of Genetic Medicine, Department of Medicine, The University of Chicago, Chicago, Illinois, United States of America

Christopher D. Brown

caseybrown@uchicago.edu

Affiliations Institute for Genomics and Systems Biology, The University of Chicago and Argonne National Laboratory, Chicago, Illinois, United States of America, Departments of Human Genetics and Ecology and Evolution, The University of Chicago, Chicago, Illinois, United States of America

Competing Interests

The authors ND Trinklein and SF Aldred are employees of and hold stock in SwitchGear Genomics. SwitchGear Genomics sells reporter vectors commercially and is the owner by assignment of patents or patent applications related to the reporter platform. The author C Moloney is an employee of Merck Research Labs.

Author Contributions

Conceived and designed the experiments: F Innocenti, GM Cooper, E Schuetz, DA Nickerson, KE Thummel, MJ Rieder, AE Rettie, MJ Ratain, NJ Cox, CD Brown. Wrote the paper: GM Cooper, CD Brown. Initiated and administered tissue collection, storage, and sample data collection: YS Lin, E Schuetz, KE Thummel. Provided assistance with Merck data: C Moloney. Provided molecular biology technical support: JD Smith, S Mirkov, J Ramirez, W Liu. Provided bioinformatic support: IB Stanaway, ER Gamazon. Performed genotype imputation and regression analyses: GM Cooper, IB Stanaway, CD Brown. Generated and analyzed gene expression and genotyping data: GM Cooper, IB Stanaway, JD Smith, MJ Rieder, CD Brown. Performed replication analyses: GM Cooper, CD Brown. Generated and analyzed probe, promoter, and UTR resequencing data: GM Cooper, JD Smith, DA Nickerson, MJ Rieder. Performed SGG cloning and reporter assays: SF Aldred, ND Trinklein. Incorporated data into SCAN database: ER Gamazon, NJ Cox. Edited the paper: F Innocenti, GM Cooper, IB Stanaway, ER Gamazon, JD Smith, S Mirkov, J Ramirez, W Liu, YS Lin, C Moloney, SF Aldred, ND Trinklein, E Schuetz, DA Nickerson, KE Thummel, MJ Rieder, AE Rettie, MJ Ratain, NJ Cox, CD Brown.