About the Authors

Yukinori Okada

yokada@src.riken.jp

Affiliations Laboratory for Statistical Analysis, Center for Genomic Medicine (CGM), Institute of Physical and Chemical Research (RIKEN), Yokohama, Japan, Department of Allergy and Rheumatology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan

Tomomitsu Hirota

Affiliation Laboratory for Respiratory Diseases, Center for Genomic Medicine, Institute of Physical and Chemical Research, Yokohama, Japan

Yoichiro Kamatani

Affiliation Centre d'Etude du Polymorphisme Humain (CEPH), Paris, France

Atsushi Takahashi

Affiliation Laboratory for Statistical Analysis, Center for Genomic Medicine (CGM), Institute of Physical and Chemical Research (RIKEN), Yokohama, Japan

Hiroko Ohmiya

Affiliation Laboratory for Statistical Analysis, Center for Genomic Medicine (CGM), Institute of Physical and Chemical Research (RIKEN), Yokohama, Japan

Natsuhiko Kumasaka

Affiliation Laboratory for Statistical Analysis, Center for Genomic Medicine (CGM), Institute of Physical and Chemical Research (RIKEN), Yokohama, Japan

Koichiro Higasa

Affiliation Laboratory for Statistical Analysis, Center for Genomic Medicine (CGM), Institute of Physical and Chemical Research (RIKEN), Yokohama, Japan

Yumi Yamaguchi-Kabata

Affiliation Laboratory for Statistical Analysis, Center for Genomic Medicine (CGM), Institute of Physical and Chemical Research (RIKEN), Yokohama, Japan

Naoya Hosono

Affiliation Laboratory for Genotyping Development, Center for Genomic Medicine, Institute of Physical and Chemical Research, Yokohama, Japan

Michael A. Nalls

Affiliation Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America

Ming Huei Chen

Affiliations National Heart, Lung, and Blood Institute's (NHLBI) Framingham Heart Study, Framingham, Massachusetts, United States of America, Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, United States of America

Frank J. A. van Rooij

Affiliations Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands, Netherlands Consortium for Healthy Aging (NGINCHA), The Netherlands Genomics Initiative, Leiden, The Netherlands

Albert V. Smith

Affiliation Icelandic Heart Association, Kopavogur, Iceland

Toshiko Tanaka

Affiliation Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America

David J. Couper

Affiliation Collaborative Studies Coordinating Center, Department of Biostatistics, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

Neil A. Zakai

Affiliation Department of Medicine, University of Vermont College of Medicine, Burlington, Vermont, United States of America

Luigi Ferrucci

Affiliation Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America

Dan L. Longo

Affiliation Clinical Research Branch, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America

Dena G. Hernandez

Affiliation Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America

Jacqueline C. M. Witteman

Affiliations Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands, Netherlands Consortium for Healthy Aging (NGINCHA), The Netherlands Genomics Initiative, Leiden, The Netherlands

Tamara B. Harris

Affiliation Laboratory for Epidemiology, Demography, and Biometry, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America

Christopher J. O'Donnell

Affiliations National Heart, Lung, and Blood Institute's (NHLBI) Framingham Heart Study, Framingham, Massachusetts, United States of America, Division of Intramural Research, National Heart, Lung, and Blood Institute, Bethesda, Maryland, United States of America

Santhi K. Ganesh

Affiliation Division of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, United States of America

Koichi Matsuda

Affiliation Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan

Tatsuhiko Tsunoda

Affiliation Laboratory for Medical Informatics, Center for Genomic Medicine, Institute of Physical and Chemical Research, Yokohama, Japan

Toshihiro Tanaka

Affiliation Laboratory for Cardiovascular Diseases, Center for Genomic Medicine, Institute of Physical and Chemical Research, Yokohama, Japan

Michiaki Kubo

Affiliation Laboratory for Genotyping Development, Center for Genomic Medicine, Institute of Physical and Chemical Research, Yokohama, Japan

Yusuke Nakamura

Affiliation Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan

Mayumi Tamari

Affiliation Laboratory for Respiratory Diseases, Center for Genomic Medicine, Institute of Physical and Chemical Research, Yokohama, Japan

Kazuhiko Yamamoto

Affiliation Department of Allergy and Rheumatology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan

Naoyuki Kamatani

Affiliation Laboratory for Statistical Analysis, Center for Genomic Medicine (CGM), Institute of Physical and Chemical Research (RIKEN), Yokohama, Japan

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: Yukinori Okada, Christopher J O'Donnell, Santhi K Ganesh, Koichi Matsuda, Toshihiro Tanaka, Michiaki Kubo, Yusuke Nakamura, Mayumi Tamari, Kazuhiko Yamamoto, Naoyuki Kamatani. Performed the experiments: Tomomitsu Hirota, Naoya Hosono, Christopher J O'Donnell, Santhi K Ganesh, Michiaki Kubo. Analyzed the data: Yukinori Okada, Yoichiro Kamatani, Atsushi Takahashi, Hiroko Ohmiya, Natsuhiko Kumasaka, Koichiro Higasa, Yumi Yamaguchi-Kabata, Michael A Nalls, Ming H Chen, Frank JA van Rooij, Albert V Smith, Toshiko Tanaka, David J Couper, Neil A Zakai, Luigi Ferrucci, Dan L Longo, Dena G Hernandez, Jacqueline CM Witteman, Tamara B Harris, Christopher J O'Donnell, Santhi K Ganesh, Tatsuhiko Tsunoda, Naoyuki Kamatani. Contributed reagents/materials/analysis tools: Christopher J O'Donnell, Santhi K Ganesh, Michiaki Kubo, Yusuke Nakamura, Naoyuki Kamatani. Wrote the manuscript: Yukinori Okada, Santhi K Ganesh.