Alkylation Base Damage Is Converted into Repairable Double-Strand Breaks and Complex Intermediates in G2 Cells Lacking AP Endonuclease

Wenjian Ma; Jim W. Westmoreland; Dmitry A. Gordenin; Mike A. Resnick

doi:10.1371/journal.pgen.1002059

Loading metrics

Open Access

Peer-reviewed

Research Article

Alkylation Base Damage Is Converted into Repairable Double-Strand Breaks and Complex Intermediates in G2 Cells Lacking AP Endonuclease

Wenjian Ma,

Affiliation Chromosome Stability Group, Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health, Research Triangle Park, North Carolina, United States of America
⨯
Jim W. Westmoreland,

Affiliation Chromosome Stability Group, Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health, Research Triangle Park, North Carolina, United States of America
⨯
Dmitry A. Gordenin,

Affiliation Chromosome Stability Group, Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health, Research Triangle Park, North Carolina, United States of America
⨯
Mike A. Resnick

* E-mail: resnick@niehs.nih.gov

Affiliation Chromosome Stability Group, Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health, Research Triangle Park, North Carolina, United States of America
⨯

Alkylation Base Damage Is Converted into Repairable Double-Strand Breaks and Complex Intermediates in G2 Cells Lacking AP Endonuclease

Wenjian Ma,
Jim W. Westmoreland,
Dmitry A. Gordenin,
Mike A. Resnick

Published: April 28, 2011
https://doi.org/10.1371/journal.pgen.1002059

About the Authors

Wenjian Ma

Affiliation Chromosome Stability Group, Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health, Research Triangle Park, North Carolina, United States of America

Jim W. Westmoreland

Dmitry A. Gordenin

Mike A. Resnick

* E-mail: resnick@niehs.nih.gov

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: WM JWW DAG MAR. Performed the experiments: WM. Analyzed the data: WM JWW DAG MAR. Contributed reagents/materials/analysis tools: WM JWW. Wrote the paper: WM MAR.

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

DNA repair
Is the Subject Area "DNA repair" applicable to this article?

Thanks for your feedback.
Yeast
Is the Subject Area "Yeast" applicable to this article?

Thanks for your feedback.
Ethidium bromide staining
Is the Subject Area "Ethidium bromide staining" applicable to this article?

Thanks for your feedback.
Southern blot
Is the Subject Area "Southern blot" applicable to this article?

Thanks for your feedback.
Chromosomal DNA
Is the Subject Area "Chromosomal DNA" applicable to this article?

Thanks for your feedback.
Recombinational repair
Is the Subject Area "Recombinational repair" applicable to this article?

Thanks for your feedback.
Chromatids
Is the Subject Area "Chromatids" applicable to this article?

Thanks for your feedback.
DNA recombination
Is the Subject Area "DNA recombination" applicable to this article?

Thanks for your feedback.