About the Authors

Guillaume Paré

pareg@McMaster.ca

Affiliations Center for Cardiovascular Disease Prevention, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Donald W. Reynolds Center for Cardiovascular Research, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, McMaster University, Hamilton, Canada

Paul M. Ridker

Affiliations Center for Cardiovascular Disease Prevention, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Donald W. Reynolds Center for Cardiovascular Research, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

Lynda Rose

Affiliations Center for Cardiovascular Disease Prevention, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Donald W. Reynolds Center for Cardiovascular Research, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

Maja Barbalic

Affiliation Human Genetics Center and Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, Texas, United States of America

Josée Dupuis

Affiliations National Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study, Framingham, Massachusetts, United States of America, Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America

Abbas Dehghan

Affiliations Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands, The Netherlands Consortium on Healthy Aging (NCHA), Leiden, The Netherlands

Joshua C. Bis

Affiliation Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, United States of America

Emelia J. Benjamin

Affiliations National Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study, Framingham, Massachusetts, United States of America, Section of Preventive Medicine and Epidemiology, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, United States of America, Department of Epidemiology, Boston University School of Public Health, Boston, Massachusetts, United States of America

Dov Shiffman

Affiliation Celera, Alameda, California, United States of America

Alexander N. Parker

Affiliation Amgen, Cambridge, Massachusetts, United States of America

Daniel I. Chasman

Affiliations Center for Cardiovascular Disease Prevention, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Donald W. Reynolds Center for Cardiovascular Research, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

Competing Interests

DS is an employee of Celera.

Author Contributions

Conceived and designed the experiments: GP PMR ANP DIC. Performed the experiments: GP ANP DIC. Analyzed the data: GP LR MB. Contributed reagents/materials/analysis tools: GP PMR MB JD AD JCB EJB DS ANP DIC. Wrote the paper: GP.