About the Authors

Bogdan Pasaniuc

bpasaniu@hsph.harvard.edu (BP); aprice@hsph.harvard.edu (ALP)

Affiliations Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America, Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, United States of America, Broad Institute of Harvard and Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts, United States of America

Noah Zaitlen

Affiliations Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America, Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, United States of America, Broad Institute of Harvard and Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts, United States of America

Guillaume Lettre

Affiliations Montreal Heart Institute, Montréal, Canada, Département de Médecine, Université de Montréal, Montréal, Canada

Gary K. Chen

Affiliation Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, California, United States of America

Arti Tandon

Affiliations Broad Institute of Harvard and Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts, United States of America, Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America

W. H. Linda Kao

Affiliations Department of Epidemiology, Johns Hopkins University, Baltimore, Maryland, United States of America, Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins University, Baltimore, Maryland, United States of America

Ingo Ruczinski

Affiliation Department of Biostatistics, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, United States of America

Myriam Fornage

Affiliation Institute of Molecular Medicine and Division of Epidemiology, School of Public Health, University of Texas Health Sciences Center at Houston, Houston, Texas, United States of America

David S. Siscovick

Affiliations Departments of Medicine and Epidemiology, University of Washington, Seattle, Washington, United States of America, Cardiovascular Health Research Unit, University of Washington, Seattle, Washington, United States of America

Xiaofeng Zhu

Affiliation Department of Epidemiology and Biostatistics, School of Medicine, Case Western Reserve University, Cleveland, Ohio, United States of America

Emma Larkin

Affiliation Department of Medicine, Division of Allergy, Pulmonary and Critical Care, Vanderbilt University, Nashville, Tennessee, United States of America

Leslie A. Lange

Affiliation Department of Genetics, University of North Carolina, Chapel Hill, North Carolina, United States of America

L. Adrienne Cupples

Affiliation Department of Biostatistics and Epidemiology, Boston University School of Public Health, Boston, Massachusetts, United States of America

Qiong Yang

Affiliation Department of Biostatistics and Epidemiology, Boston University School of Public Health, Boston, Massachusetts, United States of America

Ermeg L. Akylbekova

Affiliation Jackson Heart Study, Jackson State University, Jackson, Mississippi, United States of America

Solomon K. Musani

Affiliation University of Mississippi Medical Center, Jackson, Mississippi, United States of America

Jasmin Divers

Affiliation Department of Biostatistical Sciences, Division of Public Health Sciences, Wake Forest University, Winston-Salem, North Carolina, United States of America

Joe Mychaleckyj

Affiliation Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia, United States of America

Mingyao Li

Affiliation Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

George J. Papanicolaou

Affiliation National Heart, Lung, and Blood Institute (NHLBI), Division of Cardiovascular Sciences, National Institutes of Health, Bethesda, Maryland, United States of America

Robert C. Millikan

Affiliations Department of Epidemiology, Gillings School of Global Public Health Chapel Hill, North Carolina, United States of America, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, United States of America

Christine B. Ambrosone

Affiliation Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, New York, United States of America

Esther M. John

Affiliations Northern California Cancer Center, Fremont, California, United States of America, Stanford University School of Medicine and Stanford Cancer Center, Stanford, California, United States of America

Leslie Bernstein

Affiliation Division of Cancer Etiology, Department of Population Science, Beckman Research Institute, City of Hope, California, United States of America

Wei Zheng

Affiliations Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Nashville, Tennessee, United States of America, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

Jennifer J. Hu

Affiliation Sylvester Comprehensive Cancer Center and Department of Epidemiology and Public Health, University of Miami Miller School of Medicine, Miami, Florida, United States of America

Regina G. Ziegler

Affiliation Epidemiology and Biostatistics Program, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, United States of America

Sarah J. Nyante

Affiliation Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, United States of America

Elisa V. Bandera

Affiliation The Cancer Institute of New Jersey, Robert Wood Johnson Medical School, New Brunswick, New Jersey, United States of America

Sue A. Ingles

Affiliation Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, California, United States of America

Michael F. Press

Affiliation Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, California, United States of America

Stephen J. Chanock

Affiliation Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, United States of America

Sandra L. Deming

Affiliation Institute for Medicine and Public Health, Vanderbilt Epidemiology Center, Nashville, Tennessee, United States of America

Jorge L. Rodriguez-Gil

Affiliation Sylvester Comprehensive Cancer Center and Department of Epidemiology and Public Health, University of Miami Miller School of Medicine, Miami, Florida, United States of America

Cameron D. Palmer

Affiliations Broad Institute of Harvard and Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts, United States of America, Divisions of Genetics and Endocrinology and Program in Genomics, Children’s Hospital Boston, Boston, Massachusetts, United States of America

Sarah Buxbaum

Affiliation Jackson Heart Study, Jackson State University, Jackson, Mississippi, United States of America

Lynette Ekunwe

Affiliation Jackson Heart Study, Jackson State University, Jackson, Mississippi, United States of America

Joel N. Hirschhorn

Affiliations Broad Institute of Harvard and Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts, United States of America, Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America, Divisions of Genetics and Endocrinology and Program in Genomics, Children’s Hospital Boston, Boston, Massachusetts, United States of America

Brian E. Henderson

Affiliation Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, California, United States of America

Simon Myers

Affiliation Department of Statistics, University of Oxford, Oxford, United Kingdom

Christopher A. Haiman

Affiliation Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, California, United States of America

David Reich

Affiliations Broad Institute of Harvard and Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts, United States of America, Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America

Nick Patterson

Affiliation Broad Institute of Harvard and Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts, United States of America

James G. Wilson

Affiliations University of Mississippi Medical Center, Jackson, Mississippi, United States of America, V. A. Medical Center, Jackson, Mississippi, United States of America

Alkes L. Price

bpasaniu@hsph.harvard.edu (BP); aprice@hsph.harvard.edu (ALP)

Affiliations Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America, Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, United States of America, Broad Institute of Harvard and Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: BP NZ CAH DR NP JGW ALP. Performed the experiments: BP. Analyzed the data: BP AT ALP. Contributed reagents/materials/analysis tools: BP GL GKC WHLK IR MF DSS XZ EL LAL LAC QY ELA SKM JD JM ML GJP RCM CBA EMJ LB WZ JJH RGZ SJN EVB SAI MFP SJC SLD JLRG CDP SB LE JNH BEH SM CAH DR NP JGW ALP. Wrote the paper: BP NZ DR NP JGW ALP.