About the Authors

Stephen Gregory Addinall

Contributed equally to this work with: Stephen Gregory Addinall, Eva-Maria Holstein, Conor Lawless

Affiliations Institute for Cell and Molecular Biosciences, Newcastle University Medical School, Newcastle upon Tyne, United Kingdom, Centre for Integrated Systems Biology of Ageing and Nutrition, Institute for Ageing and Health, Newcastle University Campus for Ageing and Vitality, Newcastle upon Tyne, United Kingdom

Eva-Maria Holstein

Contributed equally to this work with: Stephen Gregory Addinall, Eva-Maria Holstein, Conor Lawless

Affiliations Institute for Cell and Molecular Biosciences, Newcastle University Medical School, Newcastle upon Tyne, United Kingdom, Centre for Integrated Systems Biology of Ageing and Nutrition, Institute for Ageing and Health, Newcastle University Campus for Ageing and Vitality, Newcastle upon Tyne, United Kingdom

Conor Lawless

Contributed equally to this work with: Stephen Gregory Addinall, Eva-Maria Holstein, Conor Lawless

Affiliation Centre for Integrated Systems Biology of Ageing and Nutrition, Institute for Ageing and Health, Newcastle University Campus for Ageing and Vitality, Newcastle upon Tyne, United Kingdom

Min Yu

Affiliations Institute for Cell and Molecular Biosciences, Newcastle University Medical School, Newcastle upon Tyne, United Kingdom, Centre for Integrated Systems Biology of Ageing and Nutrition, Institute for Ageing and Health, Newcastle University Campus for Ageing and Vitality, Newcastle upon Tyne, United Kingdom

Kaye Chapman

Address Current address: Health Protection Agency North East, Citygate, Newcastle upon Tyne, United Kingdom

Affiliations Institute for Cell and Molecular Biosciences, Newcastle University Medical School, Newcastle upon Tyne, United Kingdom, Centre for Integrated Systems Biology of Ageing and Nutrition, Institute for Ageing and Health, Newcastle University Campus for Ageing and Vitality, Newcastle upon Tyne, United Kingdom

A. Peter Banks

Affiliations Institute for Cell and Molecular Biosciences, Newcastle University Medical School, Newcastle upon Tyne, United Kingdom, Centre for Integrated Systems Biology of Ageing and Nutrition, Institute for Ageing and Health, Newcastle University Campus for Ageing and Vitality, Newcastle upon Tyne, United Kingdom

Hien-Ping Ngo

Affiliation Institute for Cell and Molecular Biosciences, Newcastle University Medical School, Newcastle upon Tyne, United Kingdom

Laura Maringele

Affiliation Crucible Laboratory, Institute for Ageing and Health, Newcastle University Centre for Life, Newcastle upon Tyne, United Kingdom

Morgan Taschuk

Affiliations Centre for Integrated Systems Biology of Ageing and Nutrition, Institute for Ageing and Health, Newcastle University Campus for Ageing and Vitality, Newcastle upon Tyne, United Kingdom, School of Computing Science, Newcastle University, Newcastle Upon Tyne, United Kingdom

Alexander Young

Affiliations Centre for Integrated Systems Biology of Ageing and Nutrition, Institute for Ageing and Health, Newcastle University Campus for Ageing and Vitality, Newcastle upon Tyne, United Kingdom, School of Mathematics and Statistics, Newcastle University, Newcastle upon Tyne, United Kingdom

Adam Ciesiolka

Affiliations Institute for Cell and Molecular Biosciences, Newcastle University Medical School, Newcastle upon Tyne, United Kingdom, Centre for Integrated Systems Biology of Ageing and Nutrition, Institute for Ageing and Health, Newcastle University Campus for Ageing and Vitality, Newcastle upon Tyne, United Kingdom

Allyson Lurena Lister

Affiliations Centre for Integrated Systems Biology of Ageing and Nutrition, Institute for Ageing and Health, Newcastle University Campus for Ageing and Vitality, Newcastle upon Tyne, United Kingdom, School of Computing Science, Newcastle University, Newcastle Upon Tyne, United Kingdom

Anil Wipat

Affiliations Institute for Cell and Molecular Biosciences, Newcastle University Medical School, Newcastle upon Tyne, United Kingdom, Centre for Integrated Systems Biology of Ageing and Nutrition, Institute for Ageing and Health, Newcastle University Campus for Ageing and Vitality, Newcastle upon Tyne, United Kingdom, School of Computing Science, Newcastle University, Newcastle Upon Tyne, United Kingdom

Darren James Wilkinson

Affiliations Centre for Integrated Systems Biology of Ageing and Nutrition, Institute for Ageing and Health, Newcastle University Campus for Ageing and Vitality, Newcastle upon Tyne, United Kingdom, School of Mathematics and Statistics, Newcastle University, Newcastle upon Tyne, United Kingdom

David Lydall

d.a.lydall@ncl.ac.uk

Affiliations Institute for Cell and Molecular Biosciences, Newcastle University Medical School, Newcastle upon Tyne, United Kingdom, Centre for Integrated Systems Biology of Ageing and Nutrition, Institute for Ageing and Health, Newcastle University Campus for Ageing and Vitality, Newcastle upon Tyne, United Kingdom

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SGA EMH CL MY KC APB HPN LM DJW DL. Performed the experiments: SGA EMH CL MY KC APB HPN LM AC. Analyzed the data: SGA EMH CL MY KC APB HPN AY DJW DL. Contributed reagents/materials/analysis tools: LM MT ALL AW DJW. Wrote the paper: SGA EMH CL DJW DL.