About the Authors

Elizabeth K. Speliotes

Contributed equally to this work with: Elizabeth K. Speliotes, Laura M. Yerges-Armstrong, Jun Wu, Ruben Hernaez, Lauren J. Kim, Albert V. Smith, W. H. Linda Kao, Joel N. Hirschhorn, Ingrid B. Borecki

espeliot@med.umich.edu (EKS); iborecki@wustl.edu (IBB)

Affiliations Department of Internal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, Michigan, United States of America, Center for Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan, United States of America, Division of Gastroenterology, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Broad Institute, Cambridge, Massachusetts, United States of America

Laura M. Yerges-Armstrong

Contributed equally to this work with: Elizabeth K. Speliotes, Laura M. Yerges-Armstrong, Jun Wu, Ruben Hernaez, Lauren J. Kim, Albert V. Smith, W. H. Linda Kao, Joel N. Hirschhorn, Ingrid B. Borecki

Affiliation Division of Endocrinology, Diabetes, and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, United States of America

Jun Wu

Contributed equally to this work with: Elizabeth K. Speliotes, Laura M. Yerges-Armstrong, Jun Wu, Ruben Hernaez, Lauren J. Kim, Albert V. Smith, W. H. Linda Kao, Joel N. Hirschhorn, Ingrid B. Borecki

Affiliation Division of Statistical Genomics, Department of Genetics, Washington University, Saint Louis, Missouri, United States of America

Ruben Hernaez

Contributed equally to this work with: Elizabeth K. Speliotes, Laura M. Yerges-Armstrong, Jun Wu, Ruben Hernaez, Lauren J. Kim, Albert V. Smith, W. H. Linda Kao, Joel N. Hirschhorn, Ingrid B. Borecki

Affiliations Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America, Division of General Internal Medicine, The Johns Hopkins Hospital, Baltimore, Maryland, United States of America, Department of Internal Medicine, Washington Hospital Center, Washington D.C., United States of America

Lauren J. Kim

Contributed equally to this work with: Elizabeth K. Speliotes, Laura M. Yerges-Armstrong, Jun Wu, Ruben Hernaez, Lauren J. Kim, Albert V. Smith, W. H. Linda Kao, Joel N. Hirschhorn, Ingrid B. Borecki

Affiliation Laboratory of Epidemiology, Demography, and Biometry, Intramural Research Program, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America

Cameron D. Palmer

Affiliation Divisions of Endocrinology and Genetics and Program in Genomics, Children's Hospital, Boston, Massachusetts, United States of America

Vilmundur Gudnason

Affiliations Icelandic Heart Association, Kopavogur, Iceland, University of Iceland, Reykjavik, Iceland

Gudny Eiriksdottir

Affiliation Icelandic Heart Association, Kopavogur, Iceland

Melissa E. Garcia

Affiliation Laboratory of Epidemiology, Demography, and Biometry, Intramural Research Program, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America

Lenore J. Launer

Affiliation Laboratory of Epidemiology, Demography, and Biometry, Intramural Research Program, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America

Michael A. Nalls

Affiliation Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America

Jeanne M. Clark

Affiliations Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America, Division of General Internal Medicine, The Johns Hopkins Hospital, Baltimore, Maryland, United States of America, Welch Center for Prevention, Epidemiology, and Clinical Research, Baltimore, Maryland, United States of America

Braxton D. Mitchell

Affiliation Division of Endocrinology, Diabetes, and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, United States of America

Alan R. Shuldiner

Affiliations Division of Endocrinology, Diabetes, and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, United States of America, Geriatric Research and Education Clinical Center (GRECC), Veterans Administration Medical Center, Baltimore, Maryland, United States of America

Johannah L. Butler

Affiliations Department of Internal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, Michigan, United States of America, Center for Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan, United States of America, Divisions of Endocrinology and Genetics and Program in Genomics, Children's Hospital, Boston, Massachusetts, United States of America

Marta Tomas

Affiliations Cardiovascular Epidemiology and Genetics, Institut Municipal d'Investigació Mèdica, Barcelona, Spain, CIBER Epidemiología y Salud Pública, Barcelona, Spain

Udo Hoffmann

Affiliations Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Division of Cardiology, Massachusetts General Hospital, Boston, Massachusetts, United States of America

Shih-Jen Hwang

Affiliation Framingham Heart Study, National Heart, Lung, and Blood Institute (NHLBI), Framingham, Massachusetts, United States of America

Joseph M. Massaro

Affiliations Framingham Heart Study, National Heart, Lung, and Blood Institute (NHLBI), Framingham, Massachusetts, United States of America, Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America

Christopher J. O'Donnell

Affiliations Division of Cardiology, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Framingham Heart Study, National Heart, Lung, and Blood Institute (NHLBI), Framingham, Massachusetts, United States of America, Division of Intramural Research, National Heart, Lung, and Blood Institute, Bethesda, Maryland, United States of America

Dushyant V. Sahani

Affiliation Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts, United States of America

Veikko Salomaa

Affiliation Chronic Disease Epidemiology Unit, Department of Health Promotion and Chronic Disease Prevention, National Public Health Institute, Helsinki, Finland

Eric E. Schadt

Affiliation Pacific Biosciences, Menlo Park, California, United States of America

Stephen M. Schwartz

Affiliations Cardiovascular Health Research Unit, Departments of Medicine and Epidemiology, University of Washington, Seattle, Washington, United States of America, Department of Epidemiology, University of Washington, Seattle, Washington, United States of America

David S. Siscovick

Affiliation Cardiovascular Health Research Unit, Departments of Medicine and Epidemiology, University of Washington, Seattle, Washington, United States of America

NASH CRN

For membership information, please see Acknowledgments.

GIANT Consortium

For membership information, please see Acknowledgments.

MAGIC Investigators

For membership information, please see Acknowledgments.

Benjamin F. Voight

Affiliation Broad Institute, Cambridge, Massachusetts, United States of America

J. Jeffrey Carr

Affiliation Departments of Radiologic Sciences, Internal Medicine-Cardiology, and Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, North Carolina, United States of America

Mary F. Feitosa

Affiliation Division of Statistical Genomics, Department of Genetics, Washington University, Saint Louis, Missouri, United States of America

Tamara B. Harris

Affiliation Laboratory of Epidemiology, Demography, and Biometry, Intramural Research Program, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America

Caroline S. Fox

Affiliations Framingham Heart Study, National Heart, Lung, and Blood Institute (NHLBI), Framingham, Massachusetts, United States of America, Division of Intramural Research, National Heart, Lung, and Blood Institute, Bethesda, Maryland, United States of America

Albert V. Smith

Contributed equally to this work with: Elizabeth K. Speliotes, Laura M. Yerges-Armstrong, Jun Wu, Ruben Hernaez, Lauren J. Kim, Albert V. Smith, W. H. Linda Kao, Joel N. Hirschhorn, Ingrid B. Borecki

Affiliation Icelandic Heart Association, Kopavogur, Iceland

W. H. Linda Kao

Contributed equally to this work with: Elizabeth K. Speliotes, Laura M. Yerges-Armstrong, Jun Wu, Ruben Hernaez, Lauren J. Kim, Albert V. Smith, W. H. Linda Kao, Joel N. Hirschhorn, Ingrid B. Borecki

Affiliations Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America, Welch Center for Prevention, Epidemiology, and Clinical Research, Baltimore, Maryland, United States of America

Joel N. Hirschhorn

Contributed equally to this work with: Elizabeth K. Speliotes, Laura M. Yerges-Armstrong, Jun Wu, Ruben Hernaez, Lauren J. Kim, Albert V. Smith, W. H. Linda Kao, Joel N. Hirschhorn, Ingrid B. Borecki

Affiliations Broad Institute, Cambridge, Massachusetts, United States of America, Divisions of Endocrinology and Genetics and Program in Genomics, Children's Hospital, Boston, Massachusetts, United States of America, Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America

Ingrid B. Borecki

Contributed equally to this work with: Elizabeth K. Speliotes, Laura M. Yerges-Armstrong, Jun Wu, Ruben Hernaez, Lauren J. Kim, Albert V. Smith, W. H. Linda Kao, Joel N. Hirschhorn, Ingrid B. Borecki

espeliot@med.umich.edu (EKS); iborecki@wustl.edu (IBB)

Affiliation Division of Statistical Genomics, Department of Genetics, Washington University, Saint Louis, Missouri, United States of America

GOLD Consortium

For membership information, please see Acknowledgments.

Competing Interests

Eric E. Schadt is an employee of Pacific Biosciences.

Author Contributions

Conceived and designed the experiments: EKS CJO CSF WHLK JNH IBB. Performed the experiments: EKS LMYA JW RH JLB MFF. Analyzed the data: EKS LMYA JW RH CDP GE MEG LJL MAN SJH JMM BFV AVS. Contributed reagents/materials/analysis tools: EKS VG JMC BDM ARS MT UH JMM CJO DVS VS EES SMS DSS NASH CRN GIANT Consortium MAGIC Investigators JJC TBH CSF WHLK JNH IBB. Wrote the paper: EKS LMYA JW RH LJK CSF WHLK JNH IBB GOLD Consortium.