About the Authors

J. Gustav Smith

Contributed equally to this work with: J. Gustav Smith, Jared W. Magnani, Christopher Newton-Cheh, Emelia J. Benjamin, Reena Mehra, Alvaro Alonso, Susan R. Heckbert, Ervin R. Fox

gustav.smith@med.lu.se

Affiliations Department of Cardiology, Faculty of Medicine, Lund University, Lund, Sweden, Program for Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

Jared W. Magnani

Contributed equally to this work with: J. Gustav Smith, Jared W. Magnani, Christopher Newton-Cheh, Emelia J. Benjamin, Reena Mehra, Alvaro Alonso, Susan R. Heckbert, Ervin R. Fox

Affiliations Section of Cardiovascular Medicine, Boston University School of Medicine, Boston, Massachusetts, United States of America, National Heart, Lung and Blood Institute's Framingham Heart Study, Framingham, Massachusetts, United States of America

Cameron Palmer

Affiliation Program for Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

Yan A. Meng

Affiliation Program for Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

Elsayed Z. Soliman

Affiliation Epidemiological Cardiology Center (EPICARE), Department of Epidemiology and Prevention, Wake Forest University School of Medicine, Winston-Salem, North Carolina, United States of America

Solomon K. Musani

Affiliation Department of Medicine, Division of Cardiovascular Disease, University of Mississippi Medical Center, Jackson Heart Study, Jackson, Mississippi, United States of America

Kathleen F. Kerr

Affiliation Department of Biostatistics, School of Public Health, University of Washington, Seattle, Washington, United States of America

Renate B. Schnabel

Affiliation Medical Clinic 2 (Cardiology), Johannes-Gutenberg University, Mainz, Germany

Steven A. Lubitz

Affiliations Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States of America, Cardiovascular Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

Nona Sotoodehnia

Affiliation Division of Cardiology, Department of Medicine, University of Washington, Seattle, Washington, United States of America

Susan Redline

Affiliation Pediatrics, Case Western Reserve University, Cleveland, Ohio, United States of America

Arne Pfeufer

Affiliations Institute of Human Genetics, Klinikum Rechts der Isar der Technischen Universität München, München, Germany, Institute of Human Genetics, Helmholtz Centrum München, Neuherberg, Germany

Martina Müller

Affiliations Institute of Medical Informatics, Biometry, and Epidemiology and Department of Medicine I, University Hospital Grosshadern, Ludwig-Maximilians-Universität, Munich, Germany, Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany

Daniel S. Evans

Affiliation Diabetes Center, University of California San Francisco, San Francisco, California, United States of America

Michael A. Nalls

Affiliation Laboratory of Neurogenetics, National institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America

Yongmei Liu

Affiliation Department of Epidemiology and Prevention, Division of Public Health Sciences, Wake Forest University, Winston-Salem, North Carolina, United States of America

Anne B. Newman

Affiliation Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

Alan B. Zonderman

Affiliation National Institute on Aging, National Institute on Aging/NIH–Intramural Research Program, NIH Biomedical Research Center, Baltimore, Maryland, United States of America

Michele K. Evans

Affiliation National Institute on Aging, National Institute on Aging/NIH–Intramural Research Program, NIH Biomedical Research Center, Baltimore, Maryland, United States of America

Rajat Deo

Affiliation Division of Cardiovascular Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

Patrick T. Ellinor

Affiliations Cardiovascular Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America, Center for Human Genetic Research, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

Dina N. Paltoo

Affiliation Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, United States of America

Christopher Newton-Cheh

Contributed equally to this work with: J. Gustav Smith, Jared W. Magnani, Christopher Newton-Cheh, Emelia J. Benjamin, Reena Mehra, Alvaro Alonso, Susan R. Heckbert, Ervin R. Fox

Affiliations Program for Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Cardiovascular Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America, Center for Human Genetic Research, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

Emelia J. Benjamin

Contributed equally to this work with: J. Gustav Smith, Jared W. Magnani, Christopher Newton-Cheh, Emelia J. Benjamin, Reena Mehra, Alvaro Alonso, Susan R. Heckbert, Ervin R. Fox

Affiliations Section of Cardiovascular Medicine, Boston University School of Medicine, Boston, Massachusetts, United States of America, National Heart, Lung and Blood Institute's Framingham Heart Study, Framingham, Massachusetts, United States of America, Department of Epidemiology, School of Public Health, Boston University, Massachusetts, United States of America, Division of Preventive Medicine, Boston University School of Medicine, Boston, Massachusetts, United States of America, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts, United States of America

Reena Mehra

Contributed equally to this work with: J. Gustav Smith, Jared W. Magnani, Christopher Newton-Cheh, Emelia J. Benjamin, Reena Mehra, Alvaro Alonso, Susan R. Heckbert, Ervin R. Fox

Affiliation Department of Medicine, Case School of Medicine, Cleveland, Ohio, United States of America

Alvaro Alonso

Contributed equally to this work with: J. Gustav Smith, Jared W. Magnani, Christopher Newton-Cheh, Emelia J. Benjamin, Reena Mehra, Alvaro Alonso, Susan R. Heckbert, Ervin R. Fox

Affiliation Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota, United States of America

Susan R. Heckbert

Contributed equally to this work with: J. Gustav Smith, Jared W. Magnani, Christopher Newton-Cheh, Emelia J. Benjamin, Reena Mehra, Alvaro Alonso, Susan R. Heckbert, Ervin R. Fox

Affiliation Department of Epidemiology, University of Washington, Seattle, Washington, United States of America

Ervin R. Fox

Contributed equally to this work with: J. Gustav Smith, Jared W. Magnani, Christopher Newton-Cheh, Emelia J. Benjamin, Reena Mehra, Alvaro Alonso, Susan R. Heckbert, Ervin R. Fox

Affiliation Department of Medicine, Division of Cardiovascular Disease, University of Mississippi Medical Center, Jackson Heart Study, Jackson, Mississippi, United States of America

Candidate-gene Association Resource (CARe) Consortium

Information on the Candidate-gene Association Resource (CARe) Consortium is provided in the Acknowledgments.

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JGS JWM CNC EJB RM AA SRH EF. Performed the experiments: JGS CP YAM. Analyzed the data: JGS CP YAM CNC. Contributed reagents/materials/analysis tools: JGS CP YAM AP MM DSE MAN YL ABN ABZ MKE CNC. Wrote the paper: JGS JWM. Interpreted the results and revised the paper: EZS SKM KK RBS SAL NS SR AP MM DSE MAN RD PE DNP CNC RM EJB AA SRH EF.