About the Authors

M. Kamran Ikram

Contributed equally to this work with: M. Kamran Ikram, Sim Xueling, Richard A. Jensen, Mary Frances Cotch, Alex W. Hewitt

Affiliations Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands, Department of Ophthalmology, Erasmus Medical Center, Rotterdam, The Netherlands, Department of Neurology, Erasmus Medical Center, Rotterdam, The Netherlands

Sim Xueling

Contributed equally to this work with: M. Kamran Ikram, Sim Xueling, Richard A. Jensen, Mary Frances Cotch, Alex W. Hewitt

Affiliation Centre for Molecular Epidemiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore

Richard A. Jensen

Contributed equally to this work with: M. Kamran Ikram, Sim Xueling, Richard A. Jensen, Mary Frances Cotch, Alex W. Hewitt

Affiliations Cardiovascular Health Research Unit, University of Washington, Seattle, Washington, United States of America, Department of Epidemiology, University of Washington, Seattle, Washington, United States of America

Mary Frances Cotch

Contributed equally to this work with: M. Kamran Ikram, Sim Xueling, Richard A. Jensen, Mary Frances Cotch, Alex W. Hewitt

Affiliation Division of Epidemiology and Clinical Applications, National Eye Institute, Intramural Research Program, National Institutes of Health, Bethesda, Maryland, United States of America

Alex W. Hewitt

Contributed equally to this work with: M. Kamran Ikram, Sim Xueling, Richard A. Jensen, Mary Frances Cotch, Alex W. Hewitt

Affiliation Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne, Australia

M. Arfan Ikram

Affiliation Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands

Jie Jin Wang

Affiliations Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne, Australia, Centre for Vision Research, Department of Ophthalmology and the Westmead Millennium Institute, University of Sydney, Sydney, Australia

Ronald Klein

Affiliation Department of Ophthalmology and Visual Science, University of Wisconsin, Madison, Wisconsin, United States of America

Barbara E. K. Klein

Affiliation Department of Ophthalmology and Visual Science, University of Wisconsin, Madison, Wisconsin, United States of America

Monique M. B. Breteler

Affiliation Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands

Ning Cheung

Affiliation Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne, Australia

Gerald Liew

Affiliation Centre for Vision Research, Department of Ophthalmology and the Westmead Millennium Institute, University of Sydney, Sydney, Australia

Paul Mitchell

Affiliation Centre for Vision Research, Department of Ophthalmology and the Westmead Millennium Institute, University of Sydney, Sydney, Australia

Andre G. Uitterlinden

Affiliations Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands, Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands, Department of Clinical Chemistry, Erasmus Medical Center, Rotterdam, The Netherlands

Fernando Rivadeneira

Affiliations Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands, Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands

Albert Hofman

Affiliation Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands

Paulus T. V. M. de Jong

Affiliations Netherlands Institute of Neuroscience, Amsterdam, The Netherlands, Department of Ophthalmology, Academic Medical Center, Amsterdam, The Netherlands

Cornelia M. van Duijn

Affiliation Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands

Linda Kao

Affiliation Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, United States of America

Ching-Yu Cheng

Affiliations Department of Ophthalmology, Taipei Veterans General Hospital, Taipei, Taiwan, Department of Ophthalmology, National Yang-Ming University School of Medicine, Taipei, Taiwan

Albert Vernon Smith

Affiliations Icelandic Heart Association, Kopavogur, Iceland, Faculty of Medicine, University of Iceland, Reykjavik, Iceland

Nicole L. Glazer

Affiliations Cardiovascular Health Research Unit, University of Washington, Seattle, Washington, United States of America, Department of Medicine, University of Washington, Seattle, Washington, United States of America

Thomas Lumley

Affiliations Cardiovascular Health Research Unit, University of Washington, Seattle, Washington, United States of America, Department of Biostatistics, University of Washington, Seattle, Washington, United States of America

Barbara McKnight

Affiliations Cardiovascular Health Research Unit, University of Washington, Seattle, Washington, United States of America, Department of Biostatistics, University of Washington, Seattle, Washington, United States of America

Bruce M. Psaty

Affiliations Cardiovascular Health Research Unit, University of Washington, Seattle, Washington, United States of America, Department of Epidemiology, University of Washington, Seattle, Washington, United States of America, Department of Medicine, University of Washington, Seattle, Washington, United States of America, Department of Health Services, University of Washington, Seattle, Washington, United States of America, Center for Health Studies, Group Health, Seattle, Washington, United States of America

Fridbert Jonasson

Affiliations Department of Ophthalmology, University of Iceland, Reykjavik, Iceland, Department of Ophthalmology, Landspitalinn University Hospital, Reykjavik, Iceland

Gudny Eiriksdottir

Affiliation Icelandic Heart Association, Kopavogur, Iceland

Thor Aspelund

Affiliations Icelandic Heart Association, Kopavogur, Iceland, Department of Statistics, University of Iceland, Reykjavik, Iceland

Global BPgen Consortium

Address Membership of the Global BPgen Consortium is provided in the Acknowledgments.

Tamara B. Harris

Affiliation Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Intramural Research Program, National Institutes of Health, Bethesda, Maryland, United States of America

Lenore J. Launer

Affiliation Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Intramural Research Program, National Institutes of Health, Bethesda, Maryland, United States of America

Kent D. Taylor

Affiliation Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America

Xiaohui Li

Affiliation Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America

Sudha K. Iyengar

Affiliation Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio, United States of America

Quansheng Xi

Affiliation Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio, United States of America

Theru A. Sivakumaran

Affiliation Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio, United States of America

David A. Mackey

Affiliations Centre for Vision Research, Department of Ophthalmology and the Westmead Millennium Institute, University of Sydney, Sydney, Australia, Lions Eye Institute, University of Western Australia, Centre for Ophthalmology and Visual Science, Perth, Australia

Stuart MacGregor

Affiliation Genetics and Population Health, Queensland Institute of Medical Research, Brisbane, Australia

Nicholas G. Martin

Affiliation Genetics and Population Health, Queensland Institute of Medical Research, Brisbane, Australia

Terri L. Young

Affiliation Center for Human Genetics, Duke University Medical Center, Durham, North Carolina, United States of America

Josh C. Bis

Affiliation Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, United States of America

Kerri L. Wiggins

Affiliation Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, United States of America

Susan R. Heckbert

Affiliations Cardiovascular Health Research Unit, Department of Epidemiology, University of Washington, Seattle, Washington, United States of America, Center for Health Studies, Group Health, Seattle, Washington, United States of America

Christopher J. Hammond

Affiliation Department of Twin Research and Genetic Epidemiology, King's College London School of Medicine, St Thomas' Hospital, London, United Kingdom

Toby Andrew

Affiliation Department of Twin Research and Genetic Epidemiology, King's College London School of Medicine, St Thomas' Hospital, London, United Kingdom

Samantha Fahy

Affiliation Department of Twin Research and Genetic Epidemiology, King's College London School of Medicine, St Thomas' Hospital, London, United Kingdom

John Attia

Affiliations School of Biomedical Sciences, University of Newcastle, Callaghan, Australia, Hunter Medical Research Institute, Newcastle, Australia

Elizabeth G. Holliday

Affiliations School of Biomedical Sciences, University of Newcastle, Callaghan, Australia, Hunter Medical Research Institute, Newcastle, Australia

Rodney J. Scott

Affiliations School of Biomedical Sciences, University of Newcastle, Callaghan, Australia, Hunter Medical Research Institute, Newcastle, Australia

F. M. Amirul Islam

Affiliation Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne, Australia

Jerome I. Rotter

Affiliation Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America

Annie K. McAuley

Affiliation Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne, Australia

Eric Boerwinkle

Affiliation Human Genetics Center and Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, Texas, United States of America

E. Shyong Tai

These authors also contributed equally to this work.

Affiliations Department of Epidemiology and Public Health, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore

Vilmundur Gudnason

These authors also contributed equally to this work.

Affiliations Icelandic Heart Association, Kopavogur, Iceland, Faculty of Medicine, University of Iceland, Reykjavik, Iceland

David S. Siscovick

These authors also contributed equally to this work.

Affiliations Cardiovascular Health Research Unit, University of Washington, Seattle, Washington, United States of America, Department of Epidemiology, University of Washington, Seattle, Washington, United States of America, Department of Medicine, University of Washington, Seattle, Washington, United States of America

Johannes R. Vingerling

These authors also contributed equally to this work.

Affiliations Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands, Department of Ophthalmology, Erasmus Medical Center, Rotterdam, The Netherlands

Tien Y. Wong

ophwty@nus.edu.sg

These authors also contributed equally to this work.

Affiliations Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne, Australia, Singapore National Eye Centre and Singapore Eye Research Institute, Singapore, Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: RK BEKK MMBB NC PM AGU FR AH PTVMdJ CMvD BMP FJ GE TA LJL KDT SKI CJH JIR EB VG DSS JRV TYW. Analyzed the data: MKI SX RAJ MFC AWH MAI JJW GL FR CMvD LK CYC AVS NLG TL BM TBH XL QX TAS DAM SM NGM TLY JCB KLW SRH TA SF EGH EST TYW. Wrote the paper: MKI SX RAJ MFC AWH MAI JJW RK BEKK MMBB NC GL PM AGU AH PTVMdJ LK CYC AVS NLG TL BM BMP FJ GE TA TBH LJL KDT XL SKI QX TAS DAM SM NGM TLY CJH TA SF JA EGH RJS FMAI JIR AKM EB EST VG DSS JRV TYW.