Genetic Deletion of the Desmosomal Component Desmoplakin Promotes Tumor Microinvasion in a Mouse Model of Pancreatic Neuroendocrine Carcinogenesis

Matthew G. H. Chun; Douglas Hanahan

doi:10.1371/journal.pgen.1001120

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Peer-reviewed

Research Article

Genetic Deletion of the Desmosomal Component Desmoplakin Promotes Tumor Microinvasion in a Mouse Model of Pancreatic Neuroendocrine Carcinogenesis

Matthew G. H. Chun,

Affiliations Department of Biochemistry and Biophysics, Helen Diller Family Comprehensive Cancer Center, and Diabetes Center, University of California San Francisco, San Francisco, California, United States of America, Program in Biological Sciences, University of California San Francisco, San Francisco, California, United States of America
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Douglas Hanahan

* E-mail: dh@ucsf.edu

Affiliations Department of Biochemistry and Biophysics, Helen Diller Family Comprehensive Cancer Center, and Diabetes Center, University of California San Francisco, San Francisco, California, United States of America, Swiss Institute for Experimental Cancer Research (ISREC), Swiss Federal Institute of Technology Lausanne (EPFL), Lausanne, Switzerland
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Genetic Deletion of the Desmosomal Component Desmoplakin Promotes Tumor Microinvasion in a Mouse Model of Pancreatic Neuroendocrine Carcinogenesis

Matthew G. H. Chun,
Douglas Hanahan

Published: September 16, 2010
https://doi.org/10.1371/journal.pgen.1001120

About the Authors

Matthew G. H. Chun

Affiliations Department of Biochemistry and Biophysics, Helen Diller Family Comprehensive Cancer Center, and Diabetes Center, University of California San Francisco, San Francisco, California, United States of America, Program in Biological Sciences, University of California San Francisco, San Francisco, California, United States of America

Douglas Hanahan

* E-mail: dh@ucsf.edu

Affiliations Department of Biochemistry and Biophysics, Helen Diller Family Comprehensive Cancer Center, and Diabetes Center, University of California San Francisco, San Francisco, California, United States of America, Swiss Institute for Experimental Cancer Research (ISREC), Swiss Federal Institute of Technology Lausanne (EPFL), Lausanne, Switzerland

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MGHC DH. Performed the experiments: MGHC. Analyzed the data: MGHC DH. Wrote the paper: MGHC DH.

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Invasive tumors
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Malignant tumors
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Cancers and neoplasms
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Pancreatic cancer
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Immunofluorescence staining
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Mouse models
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Genetics
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Desmosomes
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