About the Authors

David J. Speca

dave.speca@gmail.com (DS); slm@gallo.ucsf.edu (SLM)

Address Current address: Department of Pharmacology, University of California Davis, Davis, California, United States of America

Affiliation Department of Neurology and the Ernest Gallo Clinic and Research Center, University of California San Francisco, Emeryville, California, United States of America

Daisuke Chihara

Affiliation Department of Neurology and the Ernest Gallo Clinic and Research Center, University of California San Francisco, Emeryville, California, United States of America

Amir M. Ashique

Address Current address: Department of Molecular Biology, Genentech, South San Francisco, California, United States of America

Affiliation Department of Neurology and the Ernest Gallo Clinic and Research Center, University of California San Francisco, Emeryville, California, United States of America

M. Scott Bowers

Address Current address: Department of Psychiatry, Virginia Commonwealth University, Richmond, Virginia, United States of America

Affiliation Department of Neurology and the Ernest Gallo Clinic and Research Center, University of California San Francisco, Emeryville, California, United States of America

Jonathan T. Pierce-Shimomura

Address Current address: College of Natural Sciences, Section of Neurobiology, University of Texas, Austin, Texas, United States of America

Affiliation Department of Neurology and the Ernest Gallo Clinic and Research Center, University of California San Francisco, Emeryville, California, United States of America

Jungsoo Lee

Affiliation Department of Neurology and the Ernest Gallo Clinic and Research Center, University of California San Francisco, Emeryville, California, United States of America

Nusrat Rabbee

Affiliation Department of Statistics, University of California Berkeley, Berkeley, California, United States of America

Terence P. Speed

Address Current address: Bioinformatics Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Australia

Affiliation Department of Statistics, University of California Berkeley, Berkeley, California, United States of America

Rodrigo J. Gularte

Affiliation Department of Animal Science, University of California Davis, Davis, California, United States of America

James Chitwood

Affiliation Department of Animal Science, University of California Davis, Davis, California, United States of America

Juan F. Medrano

Affiliation Department of Animal Science, University of California Davis, Davis, California, United States of America

Mark Liao

Affiliation Department of Anesthesia and Perioperative Care, University of California San Francisco, San Francisco, California, United States of America

James M. Sonner

Affiliation Department of Anesthesia and Perioperative Care, University of California San Francisco, San Francisco, California, United States of America

Edmond I. Eger II

Affiliation Department of Anesthesia and Perioperative Care, University of California San Francisco, San Francisco, California, United States of America

Andrew S. Peterson

Contributed equally to this work with: Andrew S. Peterson, Steven L. McIntire

Address Current address: Department of Molecular Biology, Genentech, South San Francisco, California, United States of America

Affiliation Department of Neurology and the Ernest Gallo Clinic and Research Center, University of California San Francisco, Emeryville, California, United States of America

Steven L. McIntire

Contributed equally to this work with: Andrew S. Peterson, Steven L. McIntire

dave.speca@gmail.com (DS); slm@gallo.ucsf.edu (SLM)

Affiliation Department of Neurology and the Ernest Gallo Clinic and Research Center, University of California San Francisco, Emeryville, California, United States of America

Competing Interests

EIE is a paid consultant of Baxter Healthcare.

Author Contributions

Conceived and designed the experiments: DJS TPS JFM EIEI ASP SLM. Performed the experiments: DJS DC AMA MSB JL NR RJG JC ML JMS EIEI. Analyzed the data: DJS DC MSB JTPS JL NR TPS RJG JFM JMS EIEI ASP SLM. Wrote the paper: DJS DC AMA MSB JTPS JL TPS RJG JC JFM EIEI ASP SLM.