About the Authors

Houman Ashrafian

Affiliation Department of Cardiovascular Medicine and Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

Louise Docherty

Affiliation Mammalian Genetics of Disease Unit, School of Medicine, University of Sheffield, Sheffield, United Kingdom

Vincenzo Leo

Affiliation Leeds Institute of Molecular Medicine, Wellcome Trust Brenner Building, St. James's University Hospital, Leeds, United Kingdom

Christopher Towlson

Affiliation Mammalian Genetics of Disease Unit, School of Medicine, University of Sheffield, Sheffield, United Kingdom

Monica Neilan

Affiliation Mammalian Genetics of Disease Unit, School of Medicine, University of Sheffield, Sheffield, United Kingdom

Violetta Steeples

Affiliation Department of Cardiovascular Medicine and Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

Craig A. Lygate

Affiliation Department of Cardiovascular Medicine and Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

Tertius Hough

Affiliation Leeds Institute of Molecular Medicine, Wellcome Trust Brenner Building, St. James's University Hospital, Leeds, United Kingdom

Stuart Townsend

Affiliation Leeds Institute of Molecular Medicine, Wellcome Trust Brenner Building, St. James's University Hospital, Leeds, United Kingdom

Debbie Williams

Affiliation Mary Lyon Centre and Mammalian Genetics Unit, Medical Research Council, Harwell, United Kingdom

Sara Wells

Affiliation Mary Lyon Centre and Mammalian Genetics Unit, Medical Research Council, Harwell, United Kingdom

Dominic Norris

Affiliation Mary Lyon Centre and Mammalian Genetics Unit, Medical Research Council, Harwell, United Kingdom

Sarah Glyn-Jones

Affiliation Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom

John Land

Affiliation Neurometabolic Unit, National Hospital, London, United Kingdom

Ivana Barbaric

Affiliation Department of Biomedical Science, University of Sheffield, Sheffield, United Kingdom

Zuzanne Lalanne

Affiliation Mary Lyon Centre and Mammalian Genetics Unit, Medical Research Council, Harwell, United Kingdom

Paul Denny

Affiliation Mary Lyon Centre and Mammalian Genetics Unit, Medical Research Council, Harwell, United Kingdom

Dorota Szumska

Affiliation Department of Cardiovascular Medicine and Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

Shoumo Bhattacharya

Affiliation Department of Cardiovascular Medicine and Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

Julian L. Griffin

Affiliation Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom

Iain Hargreaves

Affiliation Neurometabolic Unit, National Hospital, London, United Kingdom

Narcis Fernandez-Fuentes

Affiliation Leeds Institute of Molecular Medicine, Wellcome Trust Brenner Building, St. James's University Hospital, Leeds, United Kingdom

Michael Cheeseman

Affiliation Mary Lyon Centre and Mammalian Genetics Unit, Medical Research Council, Harwell, United Kingdom

Hugh Watkins

Affiliation Department of Cardiovascular Medicine and Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

T. Neil Dear

t.n.dear@leeds.ac.uk

Affiliations Mammalian Genetics of Disease Unit, School of Medicine, University of Sheffield, Sheffield, United Kingdom, Leeds Institute of Molecular Medicine, Wellcome Trust Brenner Building, St. James's University Hospital, Leeds, United Kingdom, Mary Lyon Centre and Mammalian Genetics Unit, Medical Research Council, Harwell, United Kingdom

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: HA CAL JL PD JLG IH NFF MC HW TND. Performed the experiments: HA LD VL CT MN VS CAL TH ST DW SW DN SGJ JL IB ZL DS SB IH NFF TND. Analyzed the data: HA CAL IB JLG IH MC TND. Wrote the paper: HA HW TND.