About the Authors

Hua Zhong

Affiliation Department of Genetics, Rosetta Inpharmatics, Seattle, Washington, United States of America

John Beaulaurier

Affiliation Department of Genetics, Rosetta Inpharmatics, Seattle, Washington, United States of America

Pek Yee Lum

Affiliation Department of Genetics, Rosetta Inpharmatics, Seattle, Washington, United States of America

Cliona Molony

Affiliation Department of Genetics, Rosetta Inpharmatics, Seattle, Washington, United States of America

Xia Yang

Affiliation Department of Genetics, Rosetta Inpharmatics, Seattle, Washington, United States of America

Douglas J. MacNeil

Affiliation Department of Metabolic Disorders, Merck and Co., Rahway, New Jersey, United States of America

Drew T. Weingarth

Affiliation Department of Metabolic Disorders, Merck and Co., Rahway, New Jersey, United States of America

Bin Zhang

Affiliation Department of Genetics, Rosetta Inpharmatics, Seattle, Washington, United States of America

Danielle Greenawalt

Affiliation Department of Genetics, Rosetta Inpharmatics, Seattle, Washington, United States of America

Radu Dobrin

Affiliation Department of Genetics, Rosetta Inpharmatics, Seattle, Washington, United States of America

Ke Hao

Affiliation Department of Genetics, Rosetta Inpharmatics, Seattle, Washington, United States of America

Sangsoon Woo

Affiliation Department of Biostatistics, University of Washington, Seattle, Washington, United States of America

Christine Fabre-Suver

Affiliation Department of Genetics, Rosetta Inpharmatics, Seattle, Washington, United States of America

Su Qian

Affiliation Department of Metabolic Disorders, Merck and Co., Rahway, New Jersey, United States of America

Michael R. Tota

Affiliation Department of Metabolic Disorders, Merck and Co., Rahway, New Jersey, United States of America

Mark P. Keller

Affiliation Department of Biochemistry, University of Wisconsin, Madison, Wisconsin, United States of America

Christina M. Kendziorski

Affiliation Department of Biostatistics and Medical Informatics, University of Wisconsin, Madison, Wisconsin, United States of America

Brian S. Yandell

Affiliation Department of Statistics, University of Wisconsin, Madison, Wisconsin, United States of America

Victor Castro

Affiliation Massachusetts General Hospital Weight Center, Boston, Massachusetts, United States of America

Alan D. Attie

Affiliation Department of Biochemistry, University of Wisconsin, Madison, Wisconsin, United States of America

Lee M. Kaplan

Affiliations Massachusetts General Hospital Weight Center, Boston, Massachusetts, United States of America, Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America

Eric E. Schadt

eschadt@pacificbiosciences.com

Affiliations Department of Integrative and Systems Biology, Sage Bionetworks, Seattle, Washington, United States of America, Pacific Biosciences, Menlo Park, California, United States of America

Competing Interests

The senior author (EES) is the Chief Scientific Officer of Pacific Biosciences and owns stock in that company. A number of the other authors were employees of Merck when the work presented in this manuscript was carried out.

Author Contributions

Conceived and designed the experiments: HZ EES. Performed the experiments: DTW MPK. Analyzed the data: HZ EES. Contributed reagents/materials/analysis tools: JB PYL CM XY DJM BZ DG RD KH SW CFS SQ MRT CMK BSY VC ADA LMK. Wrote the paper: HZ EES.