About the Authors

Astrid C. Haugen

Affiliation Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, United States of America

Nicholas A. Di Prospero

Affiliation Neurogenetics Branch, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland, United States of America

Joel S. Parker

Affiliation Expression Analysis, Durham, North Carolina, United States of America

Rick D. Fannin

Affiliation Laboratory of Toxicogenomics, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, United States of America

Jeff Chou

Affiliation Laboratory of Toxicogenomics, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, United States of America

Joel N. Meyer

Affiliation Nicholas School of the Environment, Duke University, Durham, North Carolina, United States of America

Christopher Halweg

Affiliation Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, United States of America

Jennifer B. Collins

Affiliation Laboratory of Toxicogenomics, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, United States of America

Alexandra Durr

Affiliations Centre de Recherche de l'Institut du Cerveau et de la Moelle Epinière, Université Pierre et Marie Curie, Paris, France, Département de Génétique et Embryologie, Hôpital Pitié-Salpêtrière, Paris, France

Kenneth Fischbeck

Affiliation Neurogenetics Branch, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland, United States of America

Bennett Van Houten

vanhoutenb@upmc.edu

Affiliations Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America, University of Pittsburgh Cancer Institute, Hillman Cancer Center, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: ACH NADP KF BVH. Performed the experiments: ACH RDF CH. Analyzed the data: ACH NADP JSP JC JNM JBC BVH. Contributed reagents/materials/analysis tools: AD. Wrote the paper: ACH BVH. Helped recruit patients and collected patient samples: NADP. Extracted the RNA and ran the chips: RDF. EPIG analysis: JC. Helped with the statistics: JNM. Helped with the RT-PCR analysis of all FRDA patients and controls: CH. Helped analyze the raw expression data: JBC. Supplied blood from older FRDA patients: AD. Helped conceive the patient study: KF.