About the Authors

Yan Guo

Contributed equally to this work with: Yan Guo, Li-Jun Tan

Affiliation Key Laboratory of Biomedical Information Engineering of Ministry of Education, and Institute of Molecular Genetics, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, People's Republic of China

Li-Jun Tan

Contributed equally to this work with: Yan Guo, Li-Jun Tan

Affiliation Molecular and Statistical Genetics Lab, College of Life Sciences, Hunan Normal University, Changsha, People's Republic of China

Shu-Feng Lei

Affiliation School of Medicine, University of Missouri Kansas City, Kansas City, Missouri, United States of America

Tie-Lin Yang

Affiliation Key Laboratory of Biomedical Information Engineering of Ministry of Education, and Institute of Molecular Genetics, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, People's Republic of China

Xiang-Ding Chen

Affiliation Molecular and Statistical Genetics Lab, College of Life Sciences, Hunan Normal University, Changsha, People's Republic of China

Feng Zhang

Affiliation Key Laboratory of Biomedical Information Engineering of Ministry of Education, and Institute of Molecular Genetics, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, People's Republic of China

Yuan Chen

Affiliation Key Laboratory of Biomedical Information Engineering of Ministry of Education, and Institute of Molecular Genetics, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, People's Republic of China

Feng Pan

Affiliation Key Laboratory of Biomedical Information Engineering of Ministry of Education, and Institute of Molecular Genetics, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, People's Republic of China

Han Yan

Affiliation Key Laboratory of Biomedical Information Engineering of Ministry of Education, and Institute of Molecular Genetics, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, People's Republic of China

Xiaogang Liu

Affiliation Key Laboratory of Biomedical Information Engineering of Ministry of Education, and Institute of Molecular Genetics, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, People's Republic of China

Qing Tian

Affiliation School of Medicine, University of Missouri Kansas City, Kansas City, Missouri, United States of America

Zhi-Xin Zhang

Affiliation Key Laboratory of Biomedical Information Engineering of Ministry of Education, and Institute of Molecular Genetics, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, People's Republic of China

Qi Zhou

Affiliation Key Laboratory of Biomedical Information Engineering of Ministry of Education, and Institute of Molecular Genetics, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, People's Republic of China

Chuan Qiu

Affiliation Key Laboratory of Biomedical Information Engineering of Ministry of Education, and Institute of Molecular Genetics, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, People's Republic of China

Shan-Shan Dong

Affiliation Key Laboratory of Biomedical Information Engineering of Ministry of Education, and Institute of Molecular Genetics, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, People's Republic of China

Xiang-Hong Xu

Affiliation Key Laboratory of Biomedical Information Engineering of Ministry of Education, and Institute of Molecular Genetics, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, People's Republic of China

Yan-Fang Guo

Affiliation Key Laboratory of Biomedical Information Engineering of Ministry of Education, and Institute of Molecular Genetics, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, People's Republic of China

Xue-Zhen Zhu

Affiliation Key Laboratory of Biomedical Information Engineering of Ministry of Education, and Institute of Molecular Genetics, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, People's Republic of China

Shan-Lin Liu

Affiliation Molecular and Statistical Genetics Lab, College of Life Sciences, Hunan Normal University, Changsha, People's Republic of China

Xiang-Li Wang

Affiliation Molecular and Statistical Genetics Lab, College of Life Sciences, Hunan Normal University, Changsha, People's Republic of China

Xi Li

Affiliation Molecular and Statistical Genetics Lab, College of Life Sciences, Hunan Normal University, Changsha, People's Republic of China

Yi Luo

Affiliation Molecular and Statistical Genetics Lab, College of Life Sciences, Hunan Normal University, Changsha, People's Republic of China

Li-Shu Zhang

Affiliation School of Medicine, University of Missouri Kansas City, Kansas City, Missouri, United States of America

Meng Li

Affiliation Department of Orthopaedics, the First Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, Xi'an, People's Republic of China

Jin-Tang Wang

Affiliation Department of Orthopaedics, the First Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, Xi'an, People's Republic of China

Ting Wen

Affiliation Department of Orthopaedics, Xiangya Hospital of Central South University, Changsha, Hunan, People's Republic of China

Betty Drees

Affiliation School of Medicine, University of Missouri Kansas City, Kansas City, Missouri, United States of America

James Hamilton

Affiliation School of Medicine, University of Missouri Kansas City, Kansas City, Missouri, United States of America

Christopher J. Papasian

Affiliation School of Medicine, University of Missouri Kansas City, Kansas City, Missouri, United States of America

Robert R. Recker

Affiliation Osteoporosis Research Center, Creighton University, Omaha, Nebraska, United States of America

Xiao-Ping Song

Affiliation Key Laboratory of Biomedical Information Engineering of Ministry of Education, and Institute of Molecular Genetics, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, People's Republic of China

Jing Cheng

Affiliation National Engineering Research Center for Beijing Biochip Technology, Beijing, People's Republic of China

Hong-Wen Deng

dengh@umkc.edu

Affiliations Key Laboratory of Biomedical Information Engineering of Ministry of Education, and Institute of Molecular Genetics, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, People's Republic of China, Molecular and Statistical Genetics Lab, College of Life Sciences, Hunan Normal University, Changsha, People's Republic of China, School of Medicine, University of Missouri Kansas City, Kansas City, Missouri, United States of America, Center of Systematic Biomedical Research, Shanghai University of Science and Technology, Shanghai, People's Republic of China

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: HWD. Performed the experiments: YG LJT SFL TLY XDC FZ YC FP HY ZXZ QZ CQ SSD XHX SLL XLW XL YL. Analyzed the data: TLY XL YFG. Contributed reagents/materials/analysis tools: QT XZZ LSZ ML JTW TW RRR XPS JC. Wrote the paper: YG. Manuscript writing revision: BD, CJP, JH.